Catalytic enantioselective domino Michael/transannular aldol reaction under bifunctional catalysis

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Date
2020-09-28
Author
Mato Santamaría, Raquel
Reyes Martín, Efraim
Carrillo Fernández, María Luisa ORCID
Uria Pujana, Uxue ORCID
Prieto Aretxabaleta, Liher ORCID
Manzano, Rubén ORCID
Vicario Hernando, José Luis ORCID
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  Estadisticas en RECOLECTA
(LA Referencia)

Chemical Communications 56 : 13149-13152(2020)
URI
http://hdl.handle.net/10810/63359
Abstract
The enantioselective Michael reaction catalyzed by a bifunctional tertiary amine/squaramide has been used to trigger a Michael/transannular aldol cascade process that leads to densely substituted bicyclo[5.4.0]undecanes and in which three contiguous stereogenic centres, one of them a tertiary alcohol moiety, have been formed in a fully stereocontrolled fashion.
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