BackBrowsing by Author "Domercq, Maria"
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An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial
Berriozabalgoitia, Rakel
; ; ; ; Yeregui Prieto, Izaskun ; ; Duñabeitia Usategui, Iratxe ; ; Domercq García, María ; Irazusta Astiazaran, Jon ; (Frontiers Media, 2020)
Maintaining the ability to walk is one of the significant challenges in people with multiple sclerosis (MS) for keeping a good quality of life as the disease and the aging process progresses. Overground robotic (OR) wearable ... -
Clemastine Induces an Impairment in Developmental Myelination
; ; Montilla López, Alejandro; ; ; ; ; Pérez Samartín, Alberto Luis ; Domercq García, María (Frontiers Media, 2022)
[EN] Abnormalities in myelination are associated to behavioral and cognitive dysfunction in neurodevelopmental psychiatric disorders. Thus, therapies to promote or accelerate myelination could potentially ameliorate symptoms ... -
Combining imaging mass spectrometry and immunohistochemistry to analyse the lipidome of spinal cord inflammation
; Montilla López, Alejandro; ; ; ; ; Domercq García, María ; Fernández González, José Andrés (Springer Nature, 2024-02)
Inflammation is a complex process that accompanies many pathologies. Actually, dysregulation of the inflammatory process is behind many autoimmune diseases. Thus, treatment of such pathologies may benefit from in-depth ... -
Contribution of P2X4 Receptors to CNS Function and Pathophysiology
Montilla López, Alejandro; Mata, Gilda Paloma; ; Domercq García, María (MDPI, 2020-08-03)
The release and extracellular action of ATP are a widespread mechanism for cell-to-cell communication in living organisms through activation of P2X and P2Y receptors expressed at the cell surface of most tissues, including ... -
Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine
Moreno, Beatriz; Lopez, Iciar; Fernández-Díez, Begoña; Gottlieb, Miroslav; ; Sánchez Gómez, María Victoria; Domercq García, María ; Giralt, Albert; Alberch, Jordi; Collon, Kevin W.; Zhang, Helen; Parent, Jack M.; Teixido, Meritxell; Giralt, Ernest; Ceña, Valentín; Posadas, Inmaculada; Martínez-Pinilla, Eva; Villoslada, Pablo; Franco, Rafael (Public Library Science, 2014-03-05)
Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ... -
Efectos de la modulación del receptor nicotínico α7 en la respuesta inflamatoria tras la isquemia cerebral: infiltración leucocitaria e integridad de la barrera hematoencefálica.
(2023-04-05)[ES] En las diferentes etapas del infarto cerebral, la inflamación es de vital importancia. Por ello, el control de la respuesta inflamatoria mediante la modulación del receptor nicotínico α7 puede ser decisivo. La ... -
Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age
; ; ; ; ; ; ; López de Jesús, Maider; ; Montilla López, Alejandro ; Domercq García, María ; ; ; ; ; (MDPI, 2021-02-09)
first_page settings Open AccessArticle Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age by Diego Delgado 1, Ane Miren Bilbao 2, Maider Beitia 1, Ane ... -
Exploring microglial targets in experimental multiple sclerosis
Montilla López, Alejandro (2022-06-30)
La esclerosis múltiple (EM) es una enfermedad crónica e inflamatoria del sistema nervioso central, que provoca desmielinización y degeneración axonal. Por su parte, la microglía es la célula inmune residente en el sistema ... -
Functional and Metabolic Characterization of Microglia Culture in a Defined Medium
Montilla López, Alejandro; Zabala Olaizola, Alazne; ; Domercq García, María (Frontiers Media, 2020-02-07)
Microglia are the endogenous immune cells of the brain and act as sensor of infection and pathologic injury to the brain, leading to a rapid plastic process of activation that culminates in the endocytosis and phagocytosis ... -
In vivo multimodal imaging of adenosine A1 receptors in neuroinflammation after experimental stroke
Joya, Ana; Ardaya Franco, María Isabel; Montilla López, Alejandro; Garbizu, Maider; Plaza García, Sandra; Gómez Vallejo, Vanessa; Padró, Daniel; Gutiérrez Martín, Juan José; Ríos, Xabier; Ramos Cabrer, Pedro; Cossío Arrieta, Unai; Pulagam, Krishna Reddy; Higuchi, Makoto; Domercq García, María ; Cavaliere, Fabio; ; Llop Roig, Jordi ; Martín Muñoz, Abraham (Ivyspring International Publisher, 2021)
Adenosine A(l) receptors (A(l)ARs) are promising imaging biomarkers and targets for the treatment of stroke. Nevertheless, the role of A(l)ARs on ischemic damage and its subsequent neuroinflammatory response has been ... -
Increased expression of cystine/glutamate antiporter in multiple sclerosis
Pampliega Ormaetxea, Olatz; Domercq García, María ; Soria Lannes, Federico Nicolás ; ; ; (BioMed Central, 2011-06-03)
Background: Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS patients is elevated, a feature which ... -
Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling
Martín Muñoz, Abraham; Domercq García, María; (2018-05-04)
The inflammatory response is a major factor in stroke pathophysiology and contributes to secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent work in experimental cerebral ischemia has ... -
Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis
Montilla López, Alejandro; ; ; ; ; ; ; ; Domercq García, María (SpringerNature, 2023)
In multiple sclerosis and the experimental autoimmune encephalomyelitis (EAE) model, both resident microglia and infiltrating macrophages contribute to demyelination as well as spontaneous remyelination. Nevertheless, the ... -
Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
Abiega Etxabe, Oihane; Beccari Galeano, Marlene Soledad; Diaz-Aparicio, Irune; Nadjar, Agnes; Layé, Sophie; Leyrolle, Quentin; Gómez-Nicola, Diego; Domercq García, María; Pérez-Samartín, Alberto; Sánchez-Zafra, Víctor; Paris Guerrero, Ignacio; Valero Gómez-Lobo, Jorge; Savage, Julie C.; Hui, Chin-Wai; Tremblay, Marie-Ève; Deudero, Juan J. P.; Brewster, Amy L.; Anderson, Anne E.; Zaldumbide Dueñas, Laura; Galbarriatu, Lara; Marinas, Ainhoa; Vivanco Ruiz, María del Mar; ; Maletic-Savatic, Mirjana; Encinas Pérez, Juan Manuel; Sierra Saavedra, Amanda (2016)
Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients ... -
Neurotransmitter signaling in the pathophysiology of microglia
Domercq García, María; Vázquez Villoldo, Nuria; (Frontiers Research Foundation, 2013)
Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ... -
P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases
Cisneros Mejorado, Abraham J.; Pérez Samartín, Alberto Luis; Domercq García, María ; Arellano, Rogelio O.; Gottlieb, Miroslav; Koch Nolte, Friedrich; (Frontiers Media, 2020-06-18)
Shortage of oxygen and nutrients in the brain induces the release of glutamate and ATP that can cause excitotoxicity and contribute to neuronal and glial damage. Our understanding of the mechanisms of ATP release and ... -
PET Imaging with [18F]FSPG Evidences the Role of System xc- on Brain Inflammation Following Cerebral Ischemia in Rats
Domercq García, María; Szczupak, Boguslaw; Gejo, Jon; Gómez-Vallejo, Vanessa; Padró, Daniel; Gona, Kiran Babu; Dollé, Frédéric; Higuchi, Makoto; ; Llop Roig, Jordi ; Martín Muñoz, Abraham (2016)
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Purinergic P2X4 receptors modulate neuroinflammation and repair in experimental multiple sclerosis
(2019-02-25)La microglía examina el microambiente del sistema nervioso central para detectar señales de lesión o infección, y es esencial para el inicio y resolución de la inflamación inducida por patógenos o daño en los tejidos. ... -
Role of Mitochondrial Dynamics in Microglial Activation and Metabolic Switch
Montilla López, Alejandro; Ruiz Núñez, Asier ; Márquez Ropero, Mar; Sierra Saavedra, Amanda; ; Domercq García, María (American Association Of Immunologists, 2021-08-10)
Microglia act as sensors of injury in the brain, favoring its homeostasis. Their activation and polarization toward a proinflammatory phenotype are associated with injury and disease. These processes are linked to a metabolic ... -
Signaling pathwais in oligodentdrocytes to promote myelin remodeling
(2022-03-16)Oligodendrocytes make myelin and support axons metabolically with lactate. Experience and neuronal activity can induce dynamic changes in myelination during development and in adult life, suggesting a new form of plasticity ...