BackBrowsing by Author "Buqué, Xabier"
Now showing items 1-10 of 10
-
Alzheimer de origen metabólico
(2019-01-17)[ES] La Enfermedad de Alzheimer (EA) es un trastorno neurodegenerativo, caracterizado por una disminución progresiva de las funciones cognitivas. Los datos epidemiológicos describen un incremento de su incidencia con la ... -
Atorvastatin Provides a New Lipidome Improving Early Regeneration After Partial Hepatectomy in Osteopontin Deficient Mice
; ; ; ; ; Buqué García, Xabier
; ; Martínez Chantar, María Luz ; ; ; (Nature Publishing Group, 2018-10-02)
Osteopontin (OPN), a multifunctional cytokine that controls liver glycerolipid metabolism, is involved in activation and proliferation of several liver cell types during regeneration, a condition of high metabolic demands. ... -
High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway
Bravo, Elena; Palleschi, Simonetta; ; Buqué García, Xabier; Rossi, Bárbara; Cano San José, Ainara; Napolitano, Mariarosaria; ; Botham, Kathleen M. (BioMed Central, 2011)
Background Hyperhomocysteinemia (HHcy) causes increased oxidative stress and is an independent risk factor for cardiovascular disease. Oxidative stress is now believed to be a major contributory factor in the development ... -
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
Da Silva Lima, Natalia; Fondevila, Marcos F.; Novoa, Eva; Buqué García, Xabier; Mercado Gómez, María; Gallet, Sarah; González Rellán, María Jesús; Fernández, Uxia; Loyens, Anne; García Vence, María; Chantada Vázquez, María del Pilar; Bravo López, Susana Belén; Marañón, Patricia; Senra, Ana; Escudero González, Adriana; Leiva, Magdalena; Guallar, Diana; Fidalgo, Miguel; Gomes, Pedro; Claret, Marc; Sabio, Guadalupe; Varela Rey, Marta; Cardoso Delgado, Teresa de Jesús; Montero Vallejo, Rocío; Ampuero Herrojo, Javier; López, Miguel; Diéguez González, Carlos; Herrero, Laura; Serra, Dolors; Schwaninger, Markus; Prevot, Vincent; Gallego Durán, Rocío; Romero Gómez, Manuel; Iruzubieta, Paula; Crespo, Javier; Martínez Chantar, María Luz ; García Monzón, Carmelo; González Rodríguez, Águeda; ; Nogueiras Pozo, Rubén (Elsevier, 2022-01)
[EN]Background & Aims: Autophagy-related gene 3 (ATG3) is an enzyme mainly known for its actions in the LC3 lipidation process, which is essential for autophagy. Whether ATG3 plays a role in lipid metabolism or contributes ... -
Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease
; ; ; ; Buqué García, Xabier; Aurrekoetxea Galindo, Igor ; ; ; ; ; ; ; ; ; Castaño González, Luis Antonio ; ; ; Martínez Chantar, María Luz ; ; (Wiley, 2020-07-07)
[EN] Osteopontin (OPN), a senescence-associated secretory phenotype factor, is increased in patients with nonalcoholic fatty liver disease (NAFLD). Cellular senescence has been associated with age-dependent hepatosteatosis. ... -
Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis
; Buqué García, Xabier; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Aurrekoetxea Galindo, Igor ; ; ; ; ; ; ; Bañales Asurmendi, Jesús María ; ; ; Martínez Chantar, María Luz ; ; (Nature, 2022)
Altered methionine metabolism is associated with weight gain in obesity. The methionine adenosyltransferase (MAT), catalyzing the first reaction of the methionine cycle, plays an important role regulating lipid metabolism. ... -
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis
; ; ; ; ; ; ; ; ; ; ; ; ; Buqué García, Xabier; ; ; ; ; ; Bañales Asurmendi, Jesús María ; Ávila, Matías A. ; ; ; ; ; Mayor Martínez, Ugo ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-06-18)
[EN] Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic ... -
Papel de la ácido graso translocasa CD36 en la homeostasis del retículo endoplásmico hepático
(2017-09-14)La ácido graso translocasa CD36 es un transportador de ácidos grasos sin presencia y/o función destacables en el hígado sano. Sin embargo, en el hígado de pacientes con esteatohepatitis su expresión se correlaciona con el ... -
The E2F2 Transcription Factor Sustains Hepatic Glycerophospholipid Homeostasis in Mice
; Delgado Balzategui, Igotz; ; Buqué García, Xabier ; ; ; Zubiaga Elordieta, Ana María ; ; (Public Library Science, 2014-11-14)
Increasing evidence links metabolic signals to cell proliferation, but the molecular wiring that connects the two core machineries remains largely unknown. E2Fs are master regulators of cellular proliferation. We have ... -
The L-Alpha-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis
Fondevila, Marcos F.; Fernández, Uxia; González Rellán, María Jesús; Da Silva Lima, Natalia; Buqué García, Xabier; González Rodríguez, Águeda; Alonso, Cristina; Iruarrizaga Lejarreta, Marta; Delgado, Teresa C.; Varela Rey, Marta; Senra, Ana; García Outeiral, Vera; Novoa, Eva; Iglesias, Cristina; Porteiro, Begoña; Beiroa, Daniel; Folgueira, Cintia; Tojo, Marta; Torres, Jorge L.; Hernández Cosido, Lourdes; Blanco, Oscar; Arab, Juan Pablo; Barrera, Francisco; Guallar, Diana; Fidalgo, Miguel; López, Miguel; Diéguez, Carlos; Marcos, Miguel; Martínez Chantar, María Luz ; Arrese, Marco; García Monzón, Carmelo; Mato, José M.; ; Nogueiras, Ruben (Wiley, 2020-11)
Background and Aims G protein-coupled receptor (GPR) 55 is a putative cannabinoid receptor, and l-alpha-lysophosphatidylinositol (LPI) is its only known endogenous ligand. Although GPR55 has been linked to energy homeostasis ...