BackBrowsing by Author "Callado, Luis F."
Now showing items 1-20 of 27
-
Alcohol-Related Brain Damage in Humans
Erdozain Fernández, Amaia Maite
; ; ; ; ; ; ; ; ; ; Callado Hernando, Luis Felipe ; (Public Library Science, 2014-04-03)
Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann's area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control ... -
Alkohola edatearen eragina garun nerabean
Nuñez Del Moral, Amaia; Callado Hernando, Luis Felipe (Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2020)
Alcohol consumption is very accepted and highly developed in our society; and its overconsume has economic, social and health consequences. In most cases the onset of consumption occurs during adolescence. Since, the brain ... -
Calcium-binding proteins are altered in the cerebellum in schizophrenia
Vidal Domènech, Francisco; Riquelme, Gemma; Pinacho, Raquel; Rodríguez Mias, Ricard; Vera, América; Monje, Alfonso; Ferrer, Isidre; Callado Hernando, Luis Felipe; Meana Martínez, José Javier ; Villén, Judit; Ramos, Belén (Public Library Science, 2020-07-08)
Alterations in the cortico-cerebellar-thalamic-cortical circuit might underlie the diversity of symptoms in schizophrenia. However, molecular changes in cerebellar neuronal circuits, part of this network, have not yet been ... -
Cannabis use selectively modulates circulating biomarkers in the blood of schizophrenia patients
Ibarra Lecue, Inés; ; ; ; Horrillo Furundarena, Igor ; ; ; Meana Martínez, José Javier ; ; Callado Hernando, Luis Felipe ; Urigüen Echeverría, Leyre (Wiley, 2022-11)
Cannabis use disorder is frequent in schizophrenia patients, and it is associated with an earlier age of onset and poor schizophrenia prognosis. Serotonin 2A receptors (5-HT2AR) have been involved in psychosis and, like ... -
Characterization of dopamine D2 receptor coupling to G proteins in postmortem brain of subjects with schizophrenia
; ; ; ; Callado Hernando, Luis Felipe; Meana Martínez, José Javier ; Díez Alarcia, Rebeca (Springer, 2021-08)
Background: Alterations of dopamine D-1 (D1R) and D-2 receptor (D2R) are proposed in schizophrenia but brain neuroimaging and postmortem studies have shown controversial results in relation to D1R and D2R density. Besides, ... -
Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results
Fernández Fernández, Cristina; Callado Hernando, Luis Felipe; Girón, Rocío; Sánchez, Eva; Erdozain Fernández, Amaia Maite ; López-Moreno, José Antonio; Morales, Paula; Rodríguez de Fonseca, Fernando; Fernández-Ruiz, Javier; Goya, Pilar; Meana Martínez, José Javier ; Martín, Isabel; Jagerovic, Nadine (Dove Medical Press, 2014)
Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared ... -
Decreased Striatal Adenosine A(2A)-Dopamine D(2)Receptor Heteromerization in Schizophrenia
Valle León, Marta; Callado Hernando, Luis Felipe; Aso, Ester; Cajiao Manrique, María del Mar; Sahlholm, Kristoffer; López Cano, Marc; Soler, Concepcio; Altafaj, Xavier; Watanabe, Masahiko; Ferre, Sergi; Fernández Dueñas, Víctor; Menchón, José Manuel; Ciruela, Francisco (Springer Nature, 2020-10-03)
According to the adenosine hypothesis of schizophrenia, the classically associated hyperdopaminergic state may be secondary to a loss of function of the adenosinergic system. Such a hypoadenosinergic state might either be ... -
Di-aryl guanidinium derivatives: Towards improved α2-Adrenergic affinity and antagonist activity
McMullan, Michela; Kelly, Brendan; Mihigo, Helene B.; Keogh, Aaron P.; Rodríguez, Fernando; Brocos Mosquera, Iria; García Bea, Aintzane; Miranda Azpiazu, Patricia; Callado Hernando, Luis Felipe; Rozas, Isabel (Elsevier, 2021-01-01)
Compounds with excellent receptor engagement displaying alpha(2)-AR antagonist activity are useful not only for therapeutic purposes (e.g. antidepressants), but also to help in the crystallization of this particular GPCR. ... -
Differential brain ADRA2A and ADRA2C gene expression and epigenetic regulation in schizophrenia. Effect of antipsychotic drug treatment
; ; Muguruza Millán, Carolina; ; ; Meana Martínez, José Javier ; Callado Hernando, Luis Felipe ; Rivero Calera, Guadalupe (Springer Nature, 2021-12-20)
[EN] Postsynaptic alpha(2A)-adrenoceptor density is enhanced in the dorsolateral prefrontal cortex (DLPFC) of antipsychotic-treated schizophrenia subjects. This alteration might be due to transcriptional activation, and ... -
Estudio de los receptores adrenérgicos α2 y la proteína espinofilina en la corteza prefrontal postmortem de sujetos con esquizofrenia
(2021-07-08)La esquizofrenia (SZ) es una enfermedad mental crónica e incapacitante. Su etiología es de carácter multifactorial teniendo un componente genético y otro ambiental que intervienen en su aparición y el curso de la enfermedad. ... -
Glucocorticoid receptor dysregulation underlies 5-HT2AR-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model.
; Muguruza Millán, Carolina; ; ; Callado Hernando, Luis Felipe ; Meana Martínez, José Javier ; ; (Elsevier, 2022-11)
Prenatal environmental insults increase the risk of neurodevelopmental psychiatric conditions in the offspring. Structural modifications of dendritic spines are central to brain development and plasticity. Using maternal ... -
Hevin proteina matrizelularraren parte-hartzea alkoholismoan: postmortem giza garunean eta animalia-erreduetan burututako lana
(2023-01-31)Los datos recogidos en la presente Tesis Doctoral aportan conocimientos nuevos y originales sobre el patrón de expresión de la proteína matricelular hevina en el cerebro humano y su implicación en la fisiopatología del ... -
Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants
Martín-Hernández, David; Caso, Javier R.; Meana Martínez, José Javier; Callado Hernando, Luis Felipe ; Madrigal, José L. M.; García-Bueno, Borja; Leza, Juan Carlos (Biomed Central, 2018-09-04)
Background: Studies show that Toll-like receptors (TLRs), members of the innate immune system, might participate in the pathogenesis of the major depressive disorder (MDD). However, evidence of this participation in the ... -
Kannabisaren terapia erabilera
Horrillo Furundarena, Igor; Callado Hernando, Luis Felipe (Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2013)
Kalamua aspaldidanik erabili da kultura eta garai ezberdinetan zenbait gaixotasuni aurre egiteko. Lan honetan, zientziaren ikuspuntu zientifiko batetik jorratuko dugu kannabisaren eta bere eratorkinen terapia erabilera, ... -
Long-term hippocampal interneuronopathy drives sex-dimorphic spatial memory impairment induced by prenatal THC exposure
De Salas Quiroga, Adán; García Rincón, Daniel; Gómez Domínguez, Daniel; Valero, Manuel; Simón Sánchez, Samuel; Paraíso Luna, Juan; Aguareles, José; Pujadas, Mitona; Muguruza Millán, Carolina; Callado Hernando, Luis Felipe ; Lutz, Beat; Guzmán, Manuel; Menéndez de la Prida, Liset; Galve Roperh, Ismael (Nature, 2020-04)
Prenatal exposure to Delta(9)-tetrahydrocannabinol (THC), the most prominent active constituent of cannabis, alters neurodevelopmental plasticity with a long-term functional impact on adult offspring. Specifically, THC ... -
Molecular mechanisms underlying cannabis abuse and schizophrenia: Focus on 5-HT2A receptors and Akt/mTOR signaling pathway
Ibarra Lecue, Inés (2020-07-09)
Schizophrenia is a chronic and disabling mental illness that affects around 20 million people worldwide. The etiology of the disorder is multifactorial, and different genetic and environmental factors take part in its onset ... -
NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches
; ; ; ; ; ; ; ; ; ; ; ; Cuesta, Manuel J.; ; ; ; Callado Hernando, Luis Felipe; ; ; (MDPI, 2022)
Included in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. ... -
Opposite Alterations of 5¬HT2A Receptor Brain Density in Subjects with Schizophrenia: Relevance of Radiotracers Pharmacological Profile
Díez Alarcia, Rebeca; Muguruza Millán, Carolina ; Rivero Calera, Guadalupe ; García Bea, Aintzane; Gómez Vallejo, Vanessa; Callado Hernando, Luis Felipe ; Llop Roig, Jordi ; Martín Muñoz, Abraham; Meana Martínez, José Javier (Springer, 2021-05-20)
The status of serotonin 5HT2A receptors (5HT2ARs) in schizophrenia has been controversial. In vivo positron emission tomography neuroimaging and in vitro post-mortem binding studies have reported conflicting results about ... -
Oral and Palmitate Paliperidone Long-Acting Injectable Formulations’ Use in Schizophrenia Spectrum Disorders: A Retrospective Cohort Study from the First Episode Psychosis Intervention Program (CRUPEP)
Segarra Echevarria, Rafael; Recio Barbero, María; Sáenz Herrero, Margarita; Mentxaka Solozabal, Oihane; Cabezas Garduño, Janire; Eguiluz Urruchurtu, José Ignacio; Callado Hernando, Luis Felipe (Oxford University Press, 2021)
Background: Long-acting injectable antipsychotics (LAIs) may be a suitable therapeutic option for those patients in earlier stages of psychosis to avoid relapses and disease progression. Despite that, there is a lack of ... -
Papel Terapéutico del Cannabidiol en el tratamiento de los trastornos de ansiedad
(2022-01-11)[ES]Los trastornos de ansiedad conforman el motivo de consulta más frecuente en Psiquiatría. Las medidas terapéuticas existentes no siempre son eficaces y a menudo, se asocian a efectos adversos. Por otro lado, el Cannabis ...