Listar por autor "Gutierrez-Camino, Angela"
Mostrando ítems 1-20 de 22
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CircRNAome of Childhood Acute Lymphoblastic Leukemia: Deciphering Subtype-Specific Expression Profiles and Involvement in TCF3::PBX1 ALL
Gutiérrez Camino, Ángela ; Caron, Maxime; Richer, Chantal; Fuchs, Claire; Illarregi, Unai; Poncelet, Lucas; St-Onge, Pascal; Bataille, Alain R.; Tremblay-Dauphinais, Pascal; López López, Elixabet ; Camos, Mireia; Ramírez Orellana, Manuel; Astigarraga Aguirre, María Iciar; Lécuyer, Éric; Bourque, Guillaume; Martín Guerrero, Idoia; Sinnett, Daniel (MDPI, 2024-01-25)Childhood B-cell acute lymphoblastic leukemia (B-ALL) is a heterogeneous disease comprising multiple molecular subgroups with subtype-specific expression profiles. Recently, a new type of ncRNA, termed circular RNA (circRNA), ... -
Confirmation of involvement of new variants at CDKN2A/B in pediatric acute lymphoblastic leukemia susceptibility in the Spanish population
Gutiérrez Camino, Ángela ; Martín Guerrero, Idoia; García de Andoin Barandiaran, Nagore; Sastre, Ana; Carbone Bañeres, Ana; Astigarraga Aguirre, María Iciar; Navajas Gutiérrez, Aurora; García-Orad Carles, África (Public Library Science, 2017-05-08)The locus CDKN2A/B (9p21.3), which comprises the tumor suppressors genes CDKN2A and CDKN2B and the long noncoding RNA (lncRNA) known as ANRIL (or CDKN2B-AS), was associated with childhood acute lymphoblastic leukemia (ALL) ... -
Diverse mutations and structural variations contribute to Notch signaling deregulation in paediatric T-cell lymphoblastic lymphoma
Salmerón Villalobos, Julia; Ramis Zaldivar, Joan Enric; Balagué, Olga; Verdú Amorós, Jaime; Celis, Verónica; Sábado, Constantino; Garrido, Marta; Mato, Sara; Uriz, José Javier; Ortega, María José; Gutiérrez Camino, Ángela ; Sinnett, Daniel; Illarregi, Unai; Carron, Maxime; Regueiro, Alexandra; Galera, Ana; González Farre, Blanca; Campo, Elias; García, Noelia; Colomer, Dolors; Astigarraga Aguirre, María Iciar; Andrés, Mara; Llavador, Margarita; Martín Guerrero, Idoia; Salaverria, Itziar (Wiley, 2022-11)Background T-cell lymphoblastic lymphoma (T-LBL) is an aggressive neoplasm closely related to T-cell acute lymphoblastic leukaemia (T-ALL). Despite their similarities, and contrary to T-ALL, studies on paediatric T-LBL are ... -
Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia
den Hoed, M. A.; López López, Elixabet ; Te Winkel, M. L.; Tissing, W.; de Rooij, J. D.; Gutiérrez Camino, Ángela ; García-Orad Carles, África ; den Boer, E.; Pieters, R.; Pluijm, S. M.; de Jonge, R.; van den Heuvel-Eibrink, M. M. (Springer Nature, 2014-11-04)Methotrexate (MTX) is an effective and toxic chemotherapeutic drug in the treatment of pediatric acute lymphoblastic leukemia(ALL). In this prospective study, we aimed to identify metabolic and genetic determinants of MTX ... -
Genetic Variants in MiRNA Processing Genes and Pre-MiRNAs Are Associated with the Risk of Chronic Lymphocytic Leukemia
Martín Guerrero, Idoia; Gutiérrez Camino, Ángela ; López López, Elixabet ; Bilbao Aldaiturriaga, Nerea; Pombar Gómez, María; Ardanaz, Maite; García-Orad Carles, África (Public Library Science, 2015-03-20)Genome wide association studies (GWAS) have identified several low-penetrance susceptibility alleles in chronic lymphocytic leukemia (CLL). Nevertheless, these studies scarcely study regions that are implicated in non-coding ... -
Genetic variants involved in Childhood Acute Lymphoblastic Leukemia Susceptibility
La Leucemia linfoblástica aguda (LLA) infantil es el cáncer pediátrico más común. El hecho de que se desarrolle a una edad temprana sugiere que para su aparición debe existir un fuerte componente genético. Recientes GWAS ... -
Involvement of SNPs in miR-3117 and miR-3689d2 in Childhood Acute Lymphoblastic Leukemia Risk
Gutiérrez Camino, Ángela ; Martín Guerrero, Idoia; Dolzan, Vita; Jazbec, Janez; Carbone Bañeres, Ana; García de Andoin Barandiaran, Nagore; Sastre, Ana; Astigarraga Aguirre, María Iciar; Navajas Gutiérrez, Aurora; García-Orad Carles, África (Board, 2018-04-01)Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Numerous studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays, more than 2500 miRNAs have been described, that ... -
LncRNA-en adierazpen aldakorrak haurren leuzemia linfoblastiko akutuan dituen inplikazioak
Telleria, Jaione; Illarregi, Unai; López López, Elixabet ; Bilbao Aldaiturriaga, Nerea; Gutiérrez Camino, Ángela ; Martín Guerrero, Idoia (Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2023)Haurren leuzemia linfoblastiko akutua (LLA) minbizi pediatrikorik ohikoena da eta heriotza kausa nagusia 20 urte baino gutxiagoko minbizidun gaixoen artean. Aurrerapen teknologikoei esker sailkapen-zehaztasuna eta sendatze-tasa ... -
Meduloblastoma pediatrikoaren pronostikorako markatzaile molekularren identifikazioa
Frutos Gallastegui, Begoña; López López, Elixabet ; Illarregi, Unai; Bilbao Aldaiturriaga, Nerea; García Ariza, Miguel Angel; Gutiérrez Camino, Ángela ; Martín Guerrero, Idoia (Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2021)Medulloblastoma is a very heterogeneous malignancy at both clinical and molecular levels. In recent years, thanks to the development of massive and whole genome sequencing techniques, many specific mutations have been ... -
MikroRNAen potentziala B Zelula Handiko Linfoma Hedatsuaren diagnostiko, sailkapen eta pronostikoan
Larrabeiti Echevarria, Ane (2021-07-28)Potencial de los microRNAs en el diagnóstico, clasificación y pronóstico del linfoma difuso de células grandes BEl Linfoma difuso de células grandes B (LDCGB) es la neoplasia maligna linfoide más común en adultos y representa ... -
Mir-pharmacogenetics in childhood acute lymphoblastic leukemia treatment
Umérez Igartua, Maitane (2018-09-20)La leucemia Linfoblástica Aguda (LLA) es la neoplasia más frecuente en la población pediátrica. La supervivencia global de la LLA supera hoy día el 80%, en parte gracias a la intensificación del tratamiento. Sin embargo, ... -
MTHFR Polymorphisms In Childhood Acute lymphoblastic Leukemia: Influence On Methotrexate Therapy
Umerez, Maitane; Gutiérrez Camino, Ángela ; Muñoz Maldonado, Carmen; Martín Guerrero, Idoia; García-Orad Carles, África (Dove Medical Press LTD, 2017)Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide ... -
MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
Umerez, Maitane; Gutiérrez Camino, Ángela ; Muñoz Maldonado, Carmen; Martín Guerrero, Idoia; García-Orad Carles, África (Dove Medical Press, 2017-03-27)Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide ... -
Noncoding RNA-related polymorphisms in pediatric acute lymphoblastic leukemia susceptibility
Gutiérrez Camino, Ángela ; López López, Elixabet ; Martín Guerrero, Idoia; Piñán, María Ángeles; García Miguel, Purificación; Sánchez Toledo, José; Carbone Bañeres, Ana; Uriz, José Javier; Navajas Gutiérrez, Aurora; García-Orad Carles, África (Springer, 2014-03-11)Background: Evidence for an inherited genetic risk for pediatric acute lymphoblastic leukemia has been provided in several studies. Most of them focused on coding regions. However, those regions represent only 1.5% of the ... -
Osteosarkoma pediatrikoarekiko suszeptibilitatean inplikatuta dauden aldaera genetikoak
Bilbao Aldaiturriaga, Nerea; Gutiérrez Camino, Ángela ; García-Orad Carles, África ; Martín Guerrero, Idoia (Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2018)Osteosarcoma (OS) is the most common primary bone cancer that occurs primarily in children, adolescents, and young adults. The fact that OS occurs at an early age suggests that there is a strong genetic component at its ... -
Pharmacogenetics of MicroRNAs and MicroRNAs Biogenesis Machinery in Pediatric Acute Lymphoblastic Leukemia
López López, Elixabet ; Gutiérrez Camino, Ángela ; Piñán, María Ángeles; Sánchez Toledo, José; Uriz, José Javier; Ballesteros Rodríguez, Francisco Javier ; García Miguel, Purificación; Navajas Gutiérrez, Aurora; García-Orad Carles, África (Public Library Science, 2014-03-10)Despite the clinical success of acute lymphoblastic leukemia (ALL) therapy, toxicity is frequent. Therefore, it would be useful to identify predictors of adverse effects. In the last years, several studies have investigated ... -
Polimorfismo genetikoen analisien meta-analisien erabilgarritasunaren analisi kritikoa
Bilbao Aldaiturriaga, Nerea; Martín Guerrero, Idoia; Gutiérrez Camino, Ángela ; López López, Elixabet ; García-Orad Carles, África (Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2014)Azken urteotan sortzen ari den itzelezko argitalpen kopurua ikusita, meta-analisiak plazaratzen ari dira, helburu bera duten ikerketa lanen informazioa laburtzeko. Hain zuzen ere, gai jakin baten ikerketa lan desberdinen ... -
Polymorphisms in miRNA processing genes and their role in osteosarcoma risk
Bilbao Aldaiturriaga, Nerea; Gutiérrez Camino, Ángela ; Martín Guerrero, Idoia; Pombar Gómez, María; Zalacain Díez, Marta; Patiño García, Ana; López López, Elixabet ; García-Orad Carles, África (Wiley, 2015-02-07)Background The possible associations between genetic variants and osteosarcoma risk have been analyzed without conclusive results. Those studies were focused mainly on genes of biologically plausible pathways. However, ... -
Prognostic and therapeutic value of somatic mutations in diffuse large B-cell lymphoma: A systematic review
López Santillán, María; López López, Elixabet ; Álvarez González, Paula; Martinez López, Garazi; Arzuaga Mendez, Javier; Ruiz Díaz, Irune ; Guerra Merino, Isabel; Gutiérrez Camino, Ángela ; Martín Guerrero, Idoia (Elsevier, 2021-09)Diffuse large B-cell lymphoma (DLBCL), the most common type of Non-Hodgkin lymphoma (NHL), is a highly heterogeneous and aggressive disease. Regardless of this heterogeneity, all patients receive the same first-line therapy, ... -
The Role of the Dysregulation of Long Non-Coding and Circular RNA Expression in Medulloblastoma: A Systematic Review
Martinez de Estibariz, Ivan; Jakjimovska, Anastasija; Illarregi, Unai; Martín Guerrero, Idoia; Gutiérrez Camino, Ángela ; López López, Elixabet ; Bilbao Aldaiturriaga, Nerea (MDPI, 2023-09-22)Medulloblastoma (MB) is the most common malignant brain tumor in childhood. Although recent multi-omic studies have led to advances in MB classification, there is still room for improvement with regard to treatment response ...