Browsing by Author "Etxaniz, Asier"
Now showing items 1-13 of 13
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Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells
Martín Plágaro, César Augusto; Etxaniz Iriondo, Asier; Belloso Uribe, Kepa; Etxebarria Gallego, Aitor; González Bullón, David; Arluzea de Jauregizar, Jon Andoni
; Goñi Urcelay, Félix María
; Arechaga Martínez, Juan Miguel
; Ostolaza Echabe, Elena Amaya (Nature Publishing Group, 2015-09-08)
Bordetella pertussis causes whooping cough, a respiratory infectious disease that is the fifth largest cause of vaccine-preventable death in infants. Though historically considered an extracellular pathogen, this bacterium ... -
Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes
Ballesteros Rivero, Uxue; Etxaniz Iriondo, Asier; Iriondo Nagore, Marina; Varela Fernández, Yaiza; Lázaro, Melisa; Viguera Rincón, Ana Rosa; Montes Burgos, Lidia Ruth; Valle Rodríguez, Mikel Karmel; Goñi Urcelay, Félix María
; Alonso Izquierdo, Alicia
(Elsevier, 2022-05-23)
Autophagy is a process in which parts of the eukaryotic cell are selectively degraded in the lysosome. The materials to be catabolized are first surrounded by a double-membrane structure, the autophagosome. Autophagosome ... -
Bordetella pertussis-en adenilato ziklasa toxina: makrofagoetan eragindako mintz-iragazkortasun eta heriotz-zelularraren ikerketa
Etxaniz Iriondo, Asier (2017-05-24)La toxina adenilato ciclasa(ACT) es uno de los factores de virulencia mas importantes de Bordetella pertussis, la bacteria causante de la tos ferina. ACT tiene dos actividades perjudiciales para la celul la actividad ... -
Effect of ATG12–ATG5-ATG16L1 autophagy E3-like complex on the ability of LC3/GABARAP proteins to induce vesicle tethering and fusion
Iriondo Nagore, Marina; Etxaniz Iriondo, Asier; Varela Fernández, Yaiza; Ballesteros Rivero, Uxue; Lázaro, Melisa; Valle, Mikel; Fracchiolla, Dorotea; Martens, Sascha; Montes Burgos, Lidia Ruth; Goñi Urcelay, Félix María
; Alonso Izquierdo, Alicia
(Springer, 2023-02)
In macroautophagy, the autophagosome (AP) engulfs portions of cytoplasm to allow their lysosomal degradation. AP formation in humans requires the concerted action of the ATG12 and LC3/GABARAP conjugation systems. The ... -
Effects of a N-Maleimide-derivatized Phosphatidylethanolamine on the Architecture and Properties of Lipid Bilayers
Ballesteros Rivero, Uxue; González Ramírez, Emilio José; De la Arada Echevarría, Igor; Sot, Jesús; Etxaniz Iriondo, Asier; Goñi Urcelay, Félix María
; Alonso Izquierdo, Alicia
; Montes Burgos, Lidia Ruth
(MDPI, 2023-11-21)
<i>N</i>-maleimide-derivatized phospholipids are often used to facilitate protein anchoring to membranes. In autophagy studies, this is applied to the covalent binding of Atg8, an autophagy protein, to a phosphatidylethanolamine ... -
Estudio del comportamiento de vesículas en autofagia: el caso de LC3B y LC3C
Bermejillo Aroca, David (2024-05-10)[ES] La autofagia es un proceso celular conservado entre los eucariotas por el cual los componentes celulares son dirigidos hacia los lisosomas para su degradación, a través de una estructura de doble membrana llamada ... -
Irreversible versus repairable membrane poration: differences in permeabilization elicited by Bordetella Adenylate Cyclase Toxin and its hemolysin domain in macrophages
Etxaniz Iriondo, Asier; González Bullón, David; Martín Plágaro, César Augusto; Alonso, Maria Teresa; Ostolaza Echabe, Elena Amaya (FEBS Press, 2019-10-24)
Rapid plasma membrane repair in response to pore-forming toxins is crucial for cell survival, but the molecular mechanisms employed by eukaryotic nucleated cells to maintain membrane integrity and the specificities of such ... -
LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs
Iriondo Nagore, Marina; Etxaniz Iriondo, Asier; Varela Fernández, Yaiza; Ballesteros Rivero, Uxue; Hervás Hidalgo, Javier; Montes Burgos, Lidia Ruth
; Goñi Urcelay, Félix María
; Alonso Izquierdo, Alicia
(Taylor & Francis, 2022-12)
Externalization of the phospholipid cardiolipin (CL) to the outer mitochondrial membrane has been proposed to act as a mitophagy trigger. CL would act as a signal for binding the LC3 macroauto-phagy/autophagy proteins. As ... -
Lipids in Mitochondrial Macroautophagy: Phase Behavior of Bilayers Containing Cardiolipin and Ceramide
Varela Fernández, Yaiza; González Ramírez, Emilio José; Iriondo Nagore, Marina; Ballesteros Rivero, Uxue; Etxaniz Iriondo, Asier; Montes Burgos, Lidia Ruth; Goñi Urcelay, Félix María
; Alonso Izquierdo, Alicia
(MDPI, 2023-03-07)
Cardiolipin (CL) is a key lipid for damaged mitochondrial recognition by the LC3/GABARAP human autophagy proteins. The role of ceramide (Cer) in this process is unclear, but CL and Cer have been proposed to coexist in ... -
Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins
Etxaniz Iriondo, Asier; González Bullón, David; Martín Plágaro, César Augusto; Ostolaza Echabe, Elena Amaya (MDPI, 2018-06-09)
Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis. Numerous pathogenic bacteria produce pore-forming toxins that break ... -
Phase behaviour of C18-N-acyl sphingolipids, the prevalent species in human brain.
González Ramírez, Emilio José; Etxaniz Iriondo, Asier; Alonso Izquierdo, Alicia; Goñi Urcelay, Félix María
(Elsevier, 2022-11)
Lipidomic analysis of the N-acyl components of sphingolipids in different mammalian tissues had revealed that brain tissue differed from all the other samples in that SM contained mainly C18:0 and C24:1N-acyl chains, and ... -
Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes
Ostolaza Echabe, Elena Amaya; Martín Plágaro, César Augusto; González Bullón, David; Belloso Uribe, Kepa; Etxaniz Iriondo, Asier (MDPI, 2017-09-21)
Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and ... -
Zeramidek autofagian eta apoptosian duten eragina karakterizatzeko metodoa
Olarte San Juan, Andrea (2020-12-15)[EUS] Autofagia zelularen homeostasirako erabakigarria den prozesu katabolikoa da. Autofagiaren funtzioak dira egitura zitoplasmatikoen kalitatea bermatzea eta estres-egoeretan mantenugaiak eta energia sortzea. Oro har, ...