BackBrowsing by Author "Azkargorta, Mikel"
Now showing items 1-20 of 21
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A Three-Protein Panel to Support the Diagnosis of Sepsis in Children
(MDPI, 2022-03-12)Sepsis is a syndrome without a standard validated diagnostic test. Early recognition is crucial. Serum proteome analysis in children with sepsis may identify new biomarkers. This study aimed to find suitable blood biomarkers ... -
Antibacterial and antifungal activity of the human endometrial fluid during the natural cycle
; Moragues Tosantos, María Dolores
; Arrieta Aguirre, Inés ; ; ; ; ; ; ; ; ; (Hindawi, 2021-06-16)
[EN] Purpose. Some microbiota patterns have been associated with favorable IVF prognosis and others with pathological conditions. The endometrial fluid aspirate (EFA) contains antibacterial proteins that are enriched in ... -
Arachidyl Amido Cholanoic Acid Improves Liver Glucose and Lipid Homeostasis in Nonalcoholic Steatohepatitis Via AMPK and mTOR Regulation
Fernández Ramos, David; Lopitz Otsoa, Fernando; De la Cruz Villar, Laura; Bilbao García, Jon; Pagano, Martina; Mosca, Laura; Bizkarguenaga, Maider; ; ; Iruarrizaga Lejarreta, Marta; Sot, Jesús; Tsvirkun, Darya; Van Liempd, Sebastiaan Martijn; Goñi Urcelay, Félix María; Alonso, Cristina; Martínez Chantar, María Luz ; ; Hayardeny, Liat; Lu, Shelly C.; Mato, José M. (Baishideng, 2020-09-14)
BACKGROUND Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. ... -
Correlation between biological responses in vitro and in vivo to Ca-doped sol-gel coatings assessed using proteomic analysis
; ; ; ; ; ; ; ; ; Gurruchaga Torrecilla, María Dolores; Goñi Echave, Isabel María del Coro (Elsevier, 2022-12)
Poor correlation between the results of in vitro testing and the subsequent in vivo experiments hinders the design of biomaterials. Thus, new characterisation methods are needed. This study used proteomic and histological ... -
Development and characterisation of strontium-doped sol-gel coatings to optimise the initial bone regeneration processes
; ; ; ; ; ; ; Goñi Echave, Isabel María del Coro; Gurruchaga Torrecilla, María Dolores (Elsevier, 2022-12)
Strontium plays an important role in bone regeneration; it promotes the differentiation and maturation of os-teoblasts and inhibits the activity of osteoclasts. Our principal objective in this study was to formulate new ... -
Differential profile of protein expression on human keratocytes treated with autologous serum and plasma rich in growth factors (PRGF)
(Public Library Science, 2018-10-12)Purpose The main objective of this study is to compare the protein expression of human keratocytes treated with Plasma rich in growth factors (PRGF) or autologous serum (AS) and previously induced to myofibroblast by ... -
Identification of a panel of serum protein markers in early stage of sepsis and its validation in a cohort of patients
Garcia-Obregon, Susana; ; Seijas, Iratxe; Pilar-Orive, Javier; Borrego, Francisco; ; Boyano López, María Dolores; Astigarraga Aguirre, María Iciar (Elsevier, 2018-08)
Background: Sepsis is a life-threatening illness with a challenging diagnosis. Current serum biomarkers are not sensitive enough for diagnosis. With the aim of finding proteins associated with sepsis, serum protein profile ... -
Identification of proximal SUMO-dependent interactors using SUMO-ID
Barroso Gomila, Orhi; Trulsson, Erik; Muratore, Verónica; Canosa, Iñigo; Merino Cacho, Laura; Cortázar, Ana Rosa; Pérez Fernández, Coralia; ; Iloro, Ibon; Carracedo Pérez, Arkaitz; Aransay Bañares, Ana María; ; Mayor Martínez, Ugo ; Verteegal, Alfred C.O.; Barrio Olano, María Rosa; Sutherland, James D. (Nature Research, 2021-11-18)
[EN]The fast dynamics and reversibility of posttranslational modifications by the ubiquitin family pose significant challenges for research. Here we present SUMO-ID, a technology that merges proximity biotinylation by ... -
Influence of Calcium Ion-Modified Implant Surfaces in Protein Adsorption and Implant Integration
; ; ; ; ; ; ; ; Gurruchaga Torrecilla, María Dolores; Goñi Echave, Isabel María del Coro ; ; (Springer, 2021-04-21)
Background Calcium (Ca) is a well-known element in bone metabolism and blood coagulation. Here, we investigate the link between the protein adsorption pattern and the in vivo responses of surfaces modified with calcium ... -
Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease
; ; Caballero Camino, Francisco Javier; ; Rodrigues, Pedro M.; Perugorria Montiel, María Jesús; ; ; Martínez Chantar, María Luz ; ; Bujanda Fernández de Pierola, Luis ; Drenth, Joost P. H.; Bañales Asurmendi, Jesús María (Sage, 2021-09)
Background Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts, which are the main cause of morbidity. Previous studies revealed ... -
Interactome of the Autoimmune Risk Protein ANKRD55
(Frontiers Media, 2019-09-18)The ankyrin repeat domain-55 (ANKRD55) gene contains intronic single nucleotide polymorphisms (SNPs) associated with risk to contract multiple sclerosis, rheumatoid arthritis or other autoimmune disorders. Risk alleles of ... -
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease
Fernández Tussy, Pablo; Fernández Ramos, David; Lopitz Otsoa, Fernando; Simon, Jorge; Barbier Torres, Lucía; Gómez Santos, Beatriz; Nuñez García, Maitane; ; ; Gutiérrez de Juan, Virginia; ; Rodríguez Agudo, Rubén; Iruzubieta, Paula; Anguita Castillo, Juan de Dios; Castro, Rui E.; Champagne, Devin; Rincon, Mercedes; ; Arslanow, Anita; Krawczyk, Marcin; Lammert, Frank; Kirchmeyer, Melanie; Behrmann, Iris; Crespo, Javier; Lu, Shelly C.; Mato, José M.; Varela Rey, Marta; ; Delgado, Teresa C.; Martínez Chantar, María Luz (Elsevier, 2019-08-16)
Objective: Non-alcoholic fatly liver disease (NAFLD) is a complex pathology in which several dysfunctions, including alterations in metabolic pathways, mitochondrial functionality and unbalanced lipid import/export, lead ... -
Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis
; ; ; ; ; ; ; ; ; ; ; ; Arizmendi Bastarrika, Jesús María; ; ; ; Ávila, Matías A. ; Bañales Asurmendi, Jesús María ; ; ; ; ; ; ; Mayor Martínez, Ugo ; Martínez Chantar, María Luz ; (MDPI, 2020-11-27)
Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological ... -
Müller glial cells located in the peripheral retina are more susceptible to high pressure: implications for glaucoma
Pereiro Díez, Xandra; Ruzafa Andrés, Noelia ; ; ; ; ; ; Vecino Cordero, Elena (BMC, 2024)
Background Glaucoma, a progressive neurodegenerative disease, is a leading cause of irreversible vision loss worldwide. This study aims to elucidate the critical role of Müller glia (MG) in the context of retinal ganglion ... -
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis
; ; ; ; ; ; ; ; ; ; ; ; ; Buqué García, Xabier; ; ; ; ; ; Bañales Asurmendi, Jesús María ; Ávila, Matías A. ; ; ; ; ; Mayor Martínez, Ugo ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-06-18)
[EN] Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic ... -
Potential Tear Biomarkers for the Diagnosis of Parkinson’s Disease—A Pilot Study
; ; ; ; ; ; Ruzafa Andrés, Noelia; ; Pereiro Díez, Xandra ; Vecino Cordero, Elena (MDPI, 2022-01-13)
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. In this study, the tear proteome profile of patients with idiopathic PD (iPD, n = 24), carriers of the E46K-SNCA ... -
Protein adsorption/desorption dynamics on Ca-enriched titanium surfaces: biological implications
Romero Gavilán, Francisco; Cerqueira, Andreia; Anitua Aldekoa, Eduardo; Tejero, Ricardo; ; Martínez Ramos, Cristina; Ozturan, Seda; Izquierdo, Raúl; ; ; Gurruchaga Torrecilla, María Dolores; Goñi Echave, Isabel María del Coro ; Suay, Julio (Springer, 2021-08-27)
Calcium ions are used in the development of biomaterials for the promotion of coagulation, bone regeneration, and implant osseointegration. Upon implantation, the time-dependent release of calcium ions from titanium implant ... -
Proteomic Analysis of Mesenchymal Stem Cells and Monocyte Co-Cultures Exposed to a Bioactive Silica-Based Sol–Gel Coating
; ; ; ; ; Gurruchaga Torrecilla, María Dolores; Goñi Echave, Isabel María del Coro ; ; (American Chemical Society, 2023-05)
New methodologies capable of extensively analyzing the cell-material interactions are necessary to improve current in vitro characterization methods, and proteomics is a viable alternative. Also, many studies are focused ... -
Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models.
; ; ; ; Cadamuro, Massimiliano; ; ; Caballero Camino, Francisco Javier ; ; ; ; ; Martínez Chantar, María Luz ; Ávila, Matías A. ; ; CALVISI, Diego Francesco ; ; ; Castro, Rui ; ; ; Bujanda Fernández de Pierola, Luis ; ; Perugorria, Maria Jesus ; Bañales Asurmendi, Jesús María (Elsevier, 2022-07)
[EN] BACKGROUND & AIMS: Cholangiocarcinoma (CCA) comprises a heterogeneous group of malignant tumors associated with dismal prognosis. Alterations in post-translational modifications (PTMs), including NEDDylation, result ... -
Targeting UBC9-Mediated Protein Hyper-SUMOylation in Cystic Cholangiocytes Halts Polycystic Liver Disease in Experimental Models
; ; Caballero Camino, Francisco Javier; ; ; ; ; ; Martínez Chantar, María Luz ; ; ; ; ; Bujanda Fernández de Pierola, Luis ; ; Bañales Asurmendi, Jesús María (Elsevier, 2021-02)
BACKGROUND & AIMS: Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative genes participate in protein biogenesis and/or ...