Browsing by Author "Formoso, Elena"
Now showing items 1-8 of 8
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Aluminum's preferential binding site in proteins: sidechain of amino acids versus backbone interactions
Mujika, Jon I.; Dalla Torre, Gabriele; Formoso Estensoro, Elena; Grande-Aztatzi, Rafael; Grabowski, Slawomir J.; Exley, Christopher; Lopez, Xabier (Elsevier, 2017-11-11)The interaction of aluminum ion Al(III) with polypeptides is a subject of paramount importance, since it is a central feature to understand its deleterious effects in biological systems. Various drastic effects have been ... -
Does phosphorylation increase the binding affinity of aluminum? A computational study on the aluminum interaction with serine and O-phosphoserine
Formoso Estensoro, Elena; Grande-Aztatzi, Rafael; López de Pariza Sanz, Xabier (2018-12-15)Several toxic effects arise from aluminum's presence in living systems, one of these effects is to alter the natural role of enzymes and non-enzyme proteins. Aluminum promotes the hyperphosphorylation of normal proteins. ... -
Energetics and Structural Characterization of the large-scale Functional Motion of Adenylate Kinase
Formoso Estensoro, Elena; Limongelli, Vittorio; Parrinello, Michele (Nature Publishing, 2015-02-12)Adenylate Kinase (AK) is a signal transducing protein that regulates cellular energy homeostasis balancing between different conformations. An alteration of its activity can lead to severe pathologies such as heart failure, ... -
Enhancing the Photocatalytic Conversion of Pt(IV) Substrates by Flavoprotein Engineering
Gurruchaga Pereda, Juan; Martínez Martínez, Virginia ; Formoso Estensoro, Elena; Azpitarte Aguirre, Oxana; Rezabal Astigarraga, Elixabete; Lopez, Xabier; López Cortajarena, Aitziber ; Salassa, Luca (ACS, 2021-05-07)Our recent work demonstrates that certain flavoproteins can catalyze the redox activation of Pt(IV) prodrug complexes under light irradiation. Herein, we used site-directed mutagenesis on the mini singlet oxygen generator ... -
Lignin solvation by ionic liquids: The role of cation
Zubeltzu Sesé, Jon; Formoso Estensoro, Elena; Rezabal Astigarraga, Elixabete (Elsevier, 2020-01-30)The use of ionic liquids as solvents for the processing of lignocellulosic material has received considerable attention in the last years, since it presents remarkable advantages over previous solvent-based procedures. In ... -
One pot stimuli-responsive linear waterborne polyurethanes via Diels-Alder reaction
Aizpurua Lariz, June; Martín Alberdi, María Dolores; Formoso Estensoro, Elena; González Vives, Alba; Irusta Maritxalar, María Lourdes (Elsevier, 2019-01-25)Different strategies were used to obtain waterborne polyurethanes containing Diels-Alder moieties. In the first one (two pot), furan and maleimide end capped waterborne polyurethane dispersions were synthesized with the ... -
One- and Two-Electron Reductions in MiniSOG and their Implication in Catalysis
Azpitarte Aguirre, Oxana; Zudaire; Ane; Uranga, Jon; López de Pariza Sanz, Xabier; Salassa, Luca; Formoso Estensoro, Elena; Rezabal Astigarraga, Elixabete (Wiley, 2023-08)The unconventional bioorthogonal catalytic activation of anticancer metal complexes by flavin and flavoproteins photocatalysis has been reported recently. The reactivity is based on a two-electron redox reaction of the ... -
Theoretical Characterization of Pentacovalent Oxyphosphorane Intermediate Structures of the Hydrolysis of RNA catalyzed by RNase A
Formoso Estensoro, Elena (Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2010-06-25)En el presente proyecto hacemos uso de métodos teóricos para el análisis y caracterización de los mecanismos de reacción de hidrólisis del enlace fosfodiester en moléculas de ARN, y así mismo, el análisis del proceso ...