BackBrowsing by Author "Cortajarena, Aitziber"
Now showing items 1-15 of 15
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3D Printed Bioplastics with Shape-Memory Behavior Based on Native Bovine Serum Albumin
; Smith, Patrick T.
; Gómez López, Álvaro ; Fernandez, Maxence ; López Cortajarena, Aitziber ; ; Nelson, Alshakim (ACS, 2022-04-19)
Bio-based plastics that can supplant petroleum-derived materials are necessary to meet the future demands of sustainability in the life cycle of plastic materials. While there are significant efforts to develop protein-based ... -
An Emerging Nanozyme Class for à la carte Enzymatic-Like Activities based on Protein-Metal Nanocluster Hybrids
; ; ; ; López Cortajarena, Aitziber (Wiley, 2023-09)
In this study, the goal is to fabricate robust and highly efficient peroxidase-like nanozymes that can ultimately be assembled into films for their easy reuse in catalytic cycles. Nanozymes are designed by mimicking the ... -
Antibody-mediated inhibition of Wnt-11 in prostate cancer
(2021-12-13)Wnt-11 es una proteína que se encuentra altamente expresada en el cáncer de próstata metastático, donde favorece la diferenciación neuroendocrina, la supervivencia y la migración celular activando señales a través de la ... -
Design of protein-nanomaterial hybrids as tools for sensing, imaging and bioelectronics
López Martínez, Elena (2022-06-17)
El diseño de proteínas permite construir herramientas nanotecnológicas adaptadas para su uso en campos como la biomedicina o la industria. Las proteínas de repetición CTPR son una buena opción para desarrollar nano-herramientas ... -
Designed metallo-tags for probing natural systems
(2021-11-26)El objetivo de este trabajo es el diseño y desarrollo de nuevas etiquetas mediadas por proteínas para estudiar sistemas biológicamente relevantes. Específicamente, el proyecto se centra en el diseño de andamios moleculares ... -
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Engineering hybrid nanostructures for the photocatalytic activation of Pt(IV) prodrugs
(2023-06-09)In this thesis I studied the photocatalytic activation of platinum anticancer agents under blue lightirradiations. This reaction was promoted by the use of flavin molecules as catalyst. In the first part of thethesis, the ... -
Enhancing the Photocatalytic Conversion of Pt(IV) Substrates by Flavoprotein Engineering
; Martínez Martínez, Virginia; ; ; ; ; López Cortajarena, Aitziber ; (ACS, 2021-05-07)
Our recent work demonstrates that certain flavoproteins can catalyze the redox activation of Pt(IV) prodrug complexes under light irradiation. Herein, we used site-directed mutagenesis on the mini singlet oxygen generator ... -
Flavin-mediated bioorthogonal catalysis for drug activation.
(2021-10-07)En mi tesis, he investigado la combinación de conceptos catalíticos, con las propiedades fotofísicas y fotoquímicas de las flavinas para afrontar las limitaciones de la fotoquimioterapia que emplea metales. Las modestas ... -
High-throughput virtual search of small molecules for controlling the mechanical stability of human CD4
; ; ; ; ; ; ; ; ; López Cortajarena, Aitziber; ; San Sebastián Larzabal, Eider ; (Elsevier, 2024-04)
Protein mechanical stability determines the function of a myriad of proteins, especially proteins from the extracellular matrix. Failure to maintain protein mechanical stability may result in diseases and disorders such ... -
In vitro Production of Hemin-Based Artificial Metalloenzymes
; ; ; ; López Cortajarena, Aitziber (Wiley, 2024-02)
Developing enzyme alternatives is pivotal to improving and enabling new processes in biotechnology and industry. Artificial metalloenzymes (ArMs) are combinations of protein scaffolds with metal elements, such as metal ... -
Nanozymes with versatile redox capabilities inspired in metalloenzymes
; ; ; ; ; López Cortajarena, Aitziber (RSC, 2023)
Metalloenzymes represent exemplary systems in which an organic scaffold combines with a functional inorganic entity, resulting in excellent redox catalysts. Inspired by these natural hybrid biomolecules, biomolecular ... -
Natural Killer (NK) cells and cancer: nanotechnology-based new methods development for the enhancement of antitumor immunotherapy efficacy
(2022-10-06)[EU]Jakina denez, NK (ingelesetik ¿natural killer¿) eta T zelulak interleukinekin estimulatzeak, hala nolahobetu egiten ditu haien funtzio efektiboak, minbiziaren erauzteko estrategia izanik. Tesi honetannanoformulazio ... -
Novel organized multi-enzyme systems based on protein scaffolding
(2023-09-29)Este trabajo presenta tres estrategias versátiles para organizar sistemas multi-enzimáticos mediante el diseño de proteínas, creando andamiajes que combinan la organización espacial con la captura específica de intermediarios ... -
Toward Supramolecular Nanozymes for the Photocatalytic Activation of Pt(IV) Anticancer Prodrugs
Mazzei, Laura Filomena; Martínez, Álvaro; Trevisan, Lucia; Rosa Gastaldo, Daniele; López Cortajarena, Aitziber; Mancin, Fabrizio; Salassa, Luca (Royal Society Of Chemistry, 2020-09-16)
A supramolecular nanozyme for the photocatalytic conversion of a Pt(IV) anticancer complex to cisplatin is described herein. We employed 1.9 nm Au nanoparticles decorated with thiol ligands bearing a TACN (1,4,7-triazacyclononane) ...