Browsing by Author "Egaña-Huguet, Jon"
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Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus
Peñasco Iglesias, Sara; Rico Barrio, Irantzu; Puente Bustinza, Nagore ; Gómez Urquijo, Sonia María ; Fontaine, Christine J.; Egaña Huguet, Jon; Achicallende Urcaregui, Svein ; Ramos Uriarte, Almudena ; Reguero Acebal, Leire ; Elezgarai Gabantxo, Izaskun ; Nahirney, Patrick C.; Christie, Brian R.; Grandes Moreno, Pedro Rolando (Elsevier, 2019-04-22)The endocannabinoid system modulates synaptic plasticity in the hippocampus, but a link between long-term synaptic plasticity and the type 1 cannabinoid (CB1) receptor at medial perforant path (MPP) synapses remains elusive. ... -
Endokannabinoide sistemaren parte-hartzea arratoien garuntxoaren jaio osteko garapenean
Buceta Salazar, Ianire ; Rico Barrio, Irantzu; Egaña Huguet, Jon; Achicallende Urcaregui, Svein ; Terradillos Irastorza, Itziar ; Puente Bustinza, Nagore ; Reguero Acebal, Leire ; Royo, Naiara; Bonilla del Río, Itziar; Medrano, Aitor; Mendizabal Zubiaga, Juan Luis ; Gómez Urquijo, Sonia María ; Ramos, Almudena; Gerrikagoitia Marina, Inmaculada ; Grandes Moreno, Pedro Rolando ; Elezgarai Gabantxo, Izaskun (Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2018)Endokannabinoide-sistema (EKS) zelulen arteko komunikazio-sistema fisiologiko neuromodulatzaile garrantzitsuenetako bat da, eta helduaroan beraren funtzio ezagunena neurotransmisoreen doikuntza da. Azken urteotako ikerketek, ... -
Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence
Rico Barrio, Irantzu; Peñasco Iglesias, Sara; Lecumberri Odriozola, Leire; Serrano Murgia, Maitane ; Egaña Huguet, Jon; Mimenza Saiz, Amaia; Soria Gómez, Edgar ; Ramos Uriarte, Almudena ; Buceta Salazar, Ianire ; Gerrikagoitia Marina, Inmaculada ; Mendizabal Zubiaga, Juan Luis ; Elezgarai Gabantxo, Izaskun ; Puente Bustinza, Nagore ; Grandes Moreno, Pedro Rolando (MDPI, 2021-07-16)Binge drinking (BD) is a serious health concern in adolescents as high ethanol (EtOH) consumption can have cognitive sequelae later in life. Remarkably, an enriched environment (EE) in adulthood significantly recovers ... -
Impact of the transient receptor potential vanilloid 1 deletion on the endocannabinoid system in the mouse dentate gyrus
Egaña Huguet, Jon (2020-06-19)En este trabajo de tesis doctoral se ha analizado como la delección genética de un receptor afecta al resto del sistema con el que interactúa. Más concretamente, se ha establecido cuáles han sido los cambios en el sistema ... -
Lack of the transient receptor potential vanilloid 1 shifts cannabinoid-dependent excitatory synaptic plasticity in the dentate gyrus of the mouse brain hippocampus
Egaña Huguet, Jon; Saumell Esnaola, Miquel; Achicallende Urcaregui, Svein ; Soria Gómez, Edgar ; Bonilla del Río, Itziar; García del Caño, Gontzal; Barrondo Lacarra, Sergio ; Sallés Alvira, Joan; Gerrikagoitia Marina, Inmaculada ; Puente Bustinza, Nagore ; Elezgarai Gabantxo, Izaskun ; Grandes Moreno, Pedro Rolando (Frontiers Media, 2021-07-07)[EN] The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines mediates a type of long-term ... -
The Absence of the Transient Receptor Potential Vanilloid 1 Directly Impacts on the Expression and Localization of the Endocannabinoid System in the Mouse Hippocampus
Egaña Huguet, Jon; Bonilla del Río, Itziar; Gómez Urquijo, Sonia María ; Mimenza Saiz, Amaia; Saumell Esnaola, Miquel; Borrega Román, Leire; García del Caño, Gontzal; Sallés Alvira, Joan; Puente Bustinza, Nagore ; Gerrikagoitia Marina, Inmaculada ; Elezgarai Gabantxo, Izaskun ; Grandes Moreno, Pedro Rolando (Frontiers Media, 2021-02-22)The transient receptor potential vanilloid 1 (TRPV1) is a non-selective ligand-gated cation channel involved in synaptic transmission, plasticity, and brain pathology. In the hippocampal dentate gyrus, TRPV1 localizes to ... -
The Endocannabinoid System in Glial Cells and Their Profitable Interactions to Treat Epilepsy: Evidence from Animal Models
Epilepsy is one of the most common neurological conditions. Yearly, five million people are diagnosed with epileptic-related disorders. The neuroprotective and therapeutic effect of (endo)cannabinoid compounds has been ... -
Up-regulation of CB1 Cannabinoid Receptors Located at Glutamatergic Terminals in the Medial Prefrontal Cortex of the Obese Zucker Rat.
Echeazarra, Leyre; Barrondo Lacarra, Sergio ; García del Caño, Gontzal; Bonilla del Río, Itziar; Egaña Huguet, Jon; Puente Bustinza, Nagore ; Aretxabala Rodríguez, Xabier; Montaña, Mario; López de Jesús, Maider ; González Burguera, Imanol; Saumell Esnaola, Miquel; Goicolea Altuna, María Aranzazu ; Grandes Moreno, Pedro Rolando ; Sallés Alvira, Joan (Frontiers Media, 2022-10-18)The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate G i/o ...