Browsing by Author "Aurrekoetxea, Igor"

Now showing items 1-5 of 5

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      E2F1 eta E2F2 transkripzio faktoreen parte-hartzea obesitatearekin loturiko hepatokartzinomaren garapenean 

      Mestre Congregado, Daniela Constanza (2021-11-04)
      Munduko Osasun Erakundearen (OME) arabera, obesitatea osasun-egoeraren kontrako arriskua da, zeinak gorputzean gehiegizko gantz-pilaketa duen bereizgarritzat eta zeinaren munduko prebalentzia ia hirukoiztu egin den azken ...
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      Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease 

      Gómez Santos, Beatriz; Saenz de Urturi Indart, Diego; Nuñez García, Maitane; González Romero, Francisco; Buqué García, Xabier ORCID; Aurrekoetxea Galindo, Igor ORCID; Gutiérrez de Juan, Virginia; González Rellán, María Jesús; García Monzón, Carmelo; González Rodríguez, Águeda; Mosteiro González, Lorena; Errazti Olartecoechea, Gaizka; Mifsut Porcel, Patricia; Gaztambide Sáenz, María Sonia; Castaño González, Luis Antonio ORCID; Martín Plágaro, César Augusto; Nogueiras Pozo, Rubén; Martínez Chantar, María Luz ORCID; Syn, Wing-Kin; Aspichueta Celaá, Patricia (Wiley, 2020-07-07)
      [EN] Osteopontin (OPN), a senescence-associated secretory phenotype factor, is increased in patients with nonalcoholic fatty liver disease (NAFLD). Cellular senescence has been associated with age-dependent hepatosteatosis. ...
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      Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis 

      Saenz de Urturi Indart, Diego; Buqué García, Xabier ORCID; Porteiro, Begoña; Folgueira, Cintia; Mora, Alfonso; Delgado, Teresa C.; Prieto Fernández, Endika; Olaizola Rebe, Paula; Gómez Santos, Beatriz; Apodaka Biguri, Maider; González Romero, Francisco; Nieva Zuluaga, Ane; Ruiz de Gauna Madariaga, Mikel; Goikoetxea Usandizaga, Naroa; García Rodríguez, Juan Luis; Gutiérrez de Juan, Virginia; Aurrekoetxea Galindo, Igor ORCID; Montalvo Romeral, Valle; Novoa, Eva; Martín Guerrero, Idoia; Varela Rey, Marta; Bhanot, Sanjay; Lee, Richard; Bañales Asurmendi, Jesús María ORCID; Syn, Wing-Kin; Sabio, Guadalupe; Martínez Chantar, María Luz ORCID; Nogueiras Pozo, Rubén; Aspichueta Celaá, Patricia (Nature, 2022)
      Altered methionine metabolism is associated with weight gain in obesity. The methionine adenosyltransferase (MAT), catalyzing the first reaction of the methionine cycle, plays an important role regulating lipid metabolism. ...
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      “Pildorón”: ¿El fármaco del futuro? 

      Aurrekoetxea Galindo, Igor ORCID (Vicerrectorado de Calidad e Innovación Docente, 2015-06-11)
      Los estudiantes simulan estar trabajando en un laboratoio de investigación al que se le ha solicitado que realice los ensayos pre-clínicos de un fármaco en un modelo animal. A medida que los alumnos reciben los resultados ...
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      Targeting E2F Sensitizes Prostate Cancer Cells to Drug-Induced Replication Stress by Promoting Unscheduled CDK1 Activity 

      Hamidi, Mohaddase; Eriz Micieces, Ainhoa; Michelena Sánchez, Jone ORCID; Fernández Ares, Larraitz; Aurrekoetxea Galindo, Igor ORCID; Aspichueta Celaá, Patricia; Iglesias Ara, Ainhoa; Zubiaga Elordieta, Ana María ORCID (MDPI, 2022-10-10)
      E2F1/E2F2 expression correlates with malignancy in prostate cancer (PCa), but its functional significance remains unresolved. To define the mechanisms governed by E2F in PCa, we analyzed the contribution of E2F target genes ...