BackBrowsing by Author "Arregi Vado, Igor"
Now showing items 1-4 of 4
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A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K
García Santisteban, Iraia
; ; ; Urbaneja Arrue, María Ángeles ; ; Bañuelos Rodríguez, Sonia ; Rodríguez Pérez, José Antonio (Springer Nature Switzerland AG, 2016-12)
The exportin CRM1 binds nuclear export signals (NESs), and mediates active transport of NES-bearing proteins from the nucleus to the cytoplasm. Structural and biochemical analyses have uncovered the molecular mechanisms ... -
Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
Urbaneja Arrue, María Ángeles; ; ; ; López Jiménez, David ; ; ; ; Rodríguez Pérez, José Antonio ; ; Bañuelos Rodríguez, Sonia (Nature Research, 2017-10-24)
Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia ... -
Estrategias de desestabilización del estado oligomérico de la nucleofosmina
(2016-04-27)La nucleofosmina (NPM1) es una proteína nucleolar que juega un papel crítico en la biogénesis y exportación de ribosomas al citoplasma, la duplicación del centrosoma y los procesos de supresión tumoral. Se ha propuesto que ... -
Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport
; ; ; ; ; Rodríguez Pérez, José Antonio; Urbaneja Arrue, María Ángeles ; Bañuelos Rodríguez, Sonia (Public Library of Science, 2015-06-19)
Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia ...