Browsing by Author "Barreda Gómez, Gabriel"
Now showing items 1-20 of 28
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A UHPLC-Mass Spectrometry View of Human Melanocytic Cells Uncovers Potential Lipid Biomarkers of Melanoma
Pérez Valle, Arantza; Abad García, Beatriz; Fresnedo Aranguren, María Olatz; Barreda Gómez, Gabriel; Aspichueta Celaá, Patricia; Asumendi Mallea, Aintzane ; Astigarraga Arribas, Egoitz; Fernández González, José Andrés ; Boyano López, María Dolores ; Ochoa Olascoaga, Begoña (MDPI, 2021-10-08)Melanoma is the deadliest form of skin cancer due to its ability to colonize distant sites and initiate metastasis. Although these processes largely depend on the lipid-based cell membrane scaffold, our understanding of ... -
Acute Stress-Induced Changes in the Lipid Composition of Cow’s Milk in Healthy and Pathological Animals
Garro Aguilar, Yaiza; Fernández, Roberto; Calero, Silvia; Noskova, Ekaterina; Gulak, Marina; de la Fuente, Miguel; Adell, Albert; Simón Magro, Edurne ; Muzquiz, Urko; Rodríguez Piñón, Diego; Astigarraga Arribas, Egoitz; Barreda Gómez, Gabriel (2023-01-18)Producers of milk and dairy products have been faced with the challenge of responding to European society’s demand for guaranteed animal welfare production. In recent years, measures have been taken to improve animal welfare ... -
Analysis of Acetylcholinesterase Activity in Cell Membrane Microarrays of Brain Areas as a Screening Tool to Identify Tissue Specific Inhibitors
Rienda Manrique, Bárbara; Elexpe, Ane; Tolentino Cortez, Tarson; Gulak, Marina; Bruzos Cidón, Cristina ; Torrecilla Sesma, María ; Astigarraga Arribas, Egoitz; Barreda Gómez, Gabriel (MDPI, 2021-03-23)Acetylcholinesterase (AChE) is responsible for hydrolyzing the acetylcholine neurotransmitter, bringing an end point to cholinergic neurotransmission. Thus, AChE is the primary target of a wide spectrum of compounds used ... -
Analysis of different strategies for in vitro diagnosis of human humoral biomarkers based on solid support immobilization
De la Fuente López, Miguel (2023-11-03)The study of biomarkers and their detection in human fluids represents one of the best ways to improve the diagnosis and prevention of diseases. The use of human fluids for biomarker analysis can facilitate a friendly and ... -
Analysis of Mitochondrial Function in Cell Membranes as Indicator of Tissue Vulnerability to Drugs in Humans
Elexpe, Ane; Sánchez-Sánchez, Laura; Tolentino-Cortez, Tarson; Astigarraga Arribas, Egoitz; Torrecilla Sesma, María ; Barreda Gómez, Gabriel (MDPI, 2022-04-23)Drug side effects are one of the main reasons for treatment withdrawal during clinical trials. Reactive oxygen species formation is involved in many of the drug side effects, mainly by interacting with the components of ... -
Anatomical distribution of lipids in human brain cortex by imaging mass spectrometry
Veloso Fernández, Antonio; Astigarraga Arribas, Egoitz; Barreda Gómez, Gabriel; Manuel Vicente, Iván ; Ferrer, Isidro; Giralt, María Teresa; Ochoa Olascoaga, Begoña; Fresnedo Aranguren, María Olatz; Rodríguez Puertas, Rafael ; Fernández González, José Andrés (Springer Verlag, 2011-01-28)[ES] Las imágenes de masa molecular de los tejidos estarán sesgadas si las diferencias en las propiedades fisicoquímicas del microentorno afectan a la intensidad de los espectros. Para abordar esta cuestión, hemos realizado ... -
Aurrerapenak MALDI-Imaging Masa-Espektrometria teknikan: ehunen lipidoak karakterizatzen
Gárate Yeregui, Jone (2019-05-21)a imagen por espectrometría de masas es u na técnica analítica que permite obtener la distribución espacial de diferentes analitos en superficies. El objetivo de IMS en bioquímica es la de detectar los constituyentes ... -
Characterization of the Antitumor Potential of Extracts of Cannabis sativa Strains with High CBD Content in Human Neuroblastoma
Sánchez Sánchez, Laura; García Rodríguez, Javier; Fernández, Roberto; Noskova, Ekaterina; Egiguren Ortiz, June; Gulak, Marina; Ochoa, Eneko; Laso, Antonio; Oyarbide Garmendia, Juan Miguel ; Santos González, José Ignacio; Andrés, María Fe; González Coloma, Azucena; Adell, Albert; Astigarraga Arribas, Egoitz; Barreda Gómez, Gabriel (MDPI, 2023-02-14)Cannabis has been used for decades as a palliative therapy in the treatment of cancer. This is because of its beneficial effects on the pain and nausea that patients can experience as a result of chemo/radiotherapy. ... -
Comparative lipidomic analysis of mammalian retinal ganglion cells and Muller glia in situ and in vitro using High-Resolution Imaging Mass Spectrometry
Pereiro Díez, Xandra ; Fernández, Roberto; Barreda Gómez, Gabriel; Ruzafa Andrés, Noelia ; Acera Osa, Arantxa; Araiz Iribarren, José Javier; Astigarraga Arribas, Egoitz; Vecino Cordero, Elena (Nature, 2020-11-18)In order to better understand retinal physiology, alterations to which underlie some ocular diseases, we set out to establish the lipid signature of two fundamental cell types in the retina, Muller Glia and Retinal Ganglion ... -
Desarrollo de técnicas farmacológicas para la identificación y cribado de fármacos mediante microarrays de membranas celulares
García Fernández, María Dolores (2016-07-15)Los microarrays de membranas celulares han sido desarrollados como una herramienta farmacológica que permite el estudio tanto de la densidad como de la funcionalidad de las proteínas de membrana en diferentes tejidos o ... -
Dot Immunobinding Assay for the Rapid Serodetection of Scedosporium/Lomentospora in Cystic Fibrosis Patients
Martín Souto, Leire ; Antorán Díaz, Aitziber ; Areitio Beramendi, Maialen; Aparicio Fernández, Leire; Martín Gómez, María Teresa; Fernández, Roberto; Astigarraga Arribas, Egoitz; Barreda Gómez, Gabriel; Schwarz, Carsten; Rickerts, Volker; Hernando Echevarria, Fernando Luis; Rementeria Ruiz, Aitor Domingo; Buldain Garriz, Idoia; Ramírez García, Andoni (MDPI, 2023-01-24)The detection of Scedosporium/Lomentospora is still based on non-standardized low-sensitivity culture procedures. This fact is particularly worrying in patients with cystic fibrosis (CF), where these fungi are the second ... -
Efecto de la estimulación eléctrica funcional sobre la función motora y la actividad de la cadena de transporte de electrones en muestras de sangre periférica de pacientes con accidentes cerebrovasculares: Estudio cuasiexperimental sin fármacos
Larrea Rodríguez, Ane (2024-06-20)[ES] Los accidentes cerebrovasculares (ACV) cursan con trastornos motores secundarios a la lesión inicial. A nivel mitocondrial se produce un incremento del estrés oxidativo, ocasionando daño tisular y relacionándose con ... -
Effects of galanin subchronic treatment on memory and muscarinic receptors.
Barreda Gómez, Gabriel; Lombardero Iturrizaga, Laura; Giralt, María Teresa; Manuel Vicente, Iván ; Rodríguez Puertas, Rafael (Elsevier, 2015-05-07)Las vías colinérgicas, que se originan en el prosencéfalo basal y son responsables del control de diferentes procesos cognitivos como el aprendizaje y la memoria también están reguladas por algunos neuropéptidos. Uno de ... -
Elevation of Tear MMP-9 Concentration as a Biomarker of Inflammation in Ocular Pathology by Antibody Microarray Immunodetection Assays
De la Fuente López, Miguel; Rodríguez Agirretxe, Ignacio; Vecino Cordero, Elena ; Astigarraga Arribas, Egoitz; Acera Osa, Arantxa; Barreda Gómez, Gabriel (MDPI, 2022-05-18)Matrix metalloproteinases are a family of enzymes fundamental in inflammatory processes. Between them, MMP-9 is up-regulated during inflammation; thus, its quantification in non-invasive fluids is a promising approach for ... -
Enzyme Therapy: Current Challenges and Future Perspectives
De la Fuente López, Miguel; Lombardero, Laura; Gómez-González, Alfonso; Solari, Cristina; Angulo Barturen, Iñigo; Acera Osa, Arantxa; Vecino Cordero, Elena ; Astigarraga, Egoitz; Barreda Gómez, Gabriel (MDPI, 2021-08-25)In recent years, enzymes have risen as promising therapeutic tools for different pathologies, from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint problems, to cancer or cardiovascular ... -
Evaluación del efecto de la Ketamina sobre la actividad mitocondrial y el perfil lipído en células sanguíneas de pacientes con depresión resistente al tratamiento y potencial predictivo de los biomarcadores
Elexpe Iturbe, Ane (2023-07-14)La depresión es una de las enfermedades más discapacitantes en todo el mundo. Aunque se desconocen con exactitud los mecanismos patogénicos de esta enfermedad, los estudios realizados indican que puede desencadenarse, en ... -
Ketamina eta esketaminaren erabilera depresioerresistentea tratatzeko: etorkizunerako erronkak
Elexpe, Ane; Bruzos Cidón, Cristina ; Cabrera, Marta; Barreda Gómez, Gabriel; Torrecilla Sesma, María (Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua, 2021)Depressive disorders have become one of the major public health problems in recent years, not only because of their impact on quality of life, but also because of the partial response or lack of response to antidepressant ... -
Lipid fingerprint-based histology accurately classifies nevus, primary melanoma, and metastatic melanoma samples
Huergo Baños, Cristina; Velasco, Verónica; Garate Yeregui, Jone; Fernández Regueira, Roberto Antonio ; Martín Allende, Javier; Zabalza Estévez, Ignacio; Artola Igarza, Juan Luis; Martí Laborda, Rosa María; Asumendi Mallea, Aintzane ; Astigarraga, Egoitz; Barreda Gómez, Gabriel; Fresnedo Aranguren, María Olatz; Ochoa Olascoaga, Begoña; Boyano López, María Dolores ; Fernández González, José Andrés (Wiley, 2024-02)Probably, the most important factor for the survival of a melanoma patient is early detection and precise diagnosis. Although in most cases these tasks are readily carried out by pathologists and dermatologists, there are ... -
Microarrays, Enzymatic Assays, and MALDI-MS for Determining Specific Alterations to Mitochondrial Electron Transport Chain Activity, ROS Formation, and Lipid Composition in a Monkey Model of Parkinson’s Disease
García Fernández, María Dolores; Larrea, Ane; Fernández, Roberto; Rodríguez Puertas, Rafael ; Astigarraga Arribas, Egoitz; Manuel Vicente, Iván ; Barreda Gómez, Gabriel (MDPI, 2023-03-13)Multiple evidences suggest that mitochondrial dysfunction is implicated in the pathogenesis of Parkinson’s disease via the selective cell death of dopaminergic neurons, such as that which occurs after prolonged exposure ... -
Mitochondrial Metabolism in Major Depressive Disorder: From Early Diagnosis to Emerging Treatment Options
Larrea, Ane; Sánchez Sánchez, Laura; Díez Martín, Eguzkiñe; Elexpe, Ane; Torrecilla Sesma, María ; Astigarraga Arribas, Egoitz; Barreda Gómez, Gabriel (MDPI, 2024-03-17)Major Depressive Disorder (MDD) is one of the most disabling diseases in the world. MDD is traditionally diagnosed based on a patient’s symptoms, which can lead to misdiagnosis. Although the pathogenic mechanisms of MDD ...