Browsing by Author "Araujo Pasarín, Aitziber"
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Recognition of Membrane-Bound Fusion-Peptide/MPER Complexes by the HIV-1 Neutralizing 2F5 Antibody : Implications for Anti-2F5 Immunogenicity
Huarte Arrayago, Nerea; Araujo Pasarín, Aitziber; Arranz, Rocio; Lorizate Nogales, Maier; Quendler, Heribert; Kunert, Renate; Valpuesta, José M.; Nieva Escandón, José Luis (Public Library of Science, 2012-12-21)The membrane proximal external region (MPER) of the fusogenic HIV-1 glycoprotein-41 harbors the epitope sequence recognized by 2F5, a broadly neutralizing antibody isolated from an infected individual. Structural mimicry ... -
Structure and immunogenicity of a peptide vaccine, including the complete HIV-1 gp41 2F5 epitope: implications for antibody recognition mechanism and immunogen design
Serrano, Soraya; Araujo Pasarín, Aitziber; Apellaniz Unzalu, Beatriz ; Bryson, Steve; Carravilla Palomanes, Pablo; De la Arada Echevarría, Igor ; Huarte Arrayago, Nerea; Rujas Díez, Edurne; Pai, Emil F.; Arrondo, José Luis; Domene, Carmen; Jiménez, María Ángeles; Nieva Escandón, José Luis (Elsevier, 2014-01-15)The membrane-proximal external region (MPER) of gp41 harbors the epitope recognized by the broadly neutralizing anti-HIV 2F5 antibody, a research focus in HIV-1 vaccine development. In this work, we analyze the structure ...