Now showing items 1-2 of 2

    • Thumbnail

      Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia 

      Karol, S. E.; Larsen, E.; Yang, W.; Cheng, C.; Cao, X.; Ramsey, L. B.; Fernandez, C. A.; McCorkle, J. R.; Paugh, S. W.; Autry, R. J.; López López, Elixabet ORCID; Diouf, B.; Jeha, S.; Pui, C-H.; Raetz, E. A.; Winick, N. J.; Carroll, W. L.; Hunger, S. P.; Loh, M. L.; Devidas, M.; Evans, W. E.; Yang, J. J.; Relling, M. V. (Springer Nature, 2017-01-18)
      The causes of individual relapses in children with acute lymphoblastic leukemia (ALL) remain incompletely understood. We evaluated the contribution of germline genetic factors to relapse in 2225 children treated on Children's ...
    • Thumbnail

      Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia 

      Autry, R. J.; Paugh, S. W.; Carter, R.; Shi, L.; Liu, J.; Ferguson, D.; Lau, C. E.; Bonten, E. J.; Yang, W.; McCorkle, J. R.; Beard, J. A.; Panetta, J. C.; Diedrich, J.; Crews, K..R.; Pei, D.; Coke, C. J.; Natarajan, S.; Khatamian, A.; Karol, S. E.; López López, Elixabet ORCID; Diouf, B.; Smith, C.; Gocho, Y.; Hagiwara, K.; Roberts, K. G.; Pounds, S.; Kornblau, S. M.; Stock, W.; Paietta, E. M.; Litzow, M. R.; Inaba, H. (Springer Nature, 2020-03)
      Identification of genomic and epigenomic determinants of drug resistance provides important insights for improving cancer treatment. Using agnostic genome-wide interrogation of mRNA and miRNA expression, DNA methylation, ...