Browsing by Author "Barrasa González, Helena"
Now showing items 1-10 of 10
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Antibiotic susceptibility trend before and after long-term use of selective digestive decontamination: a 16 year ecological study
Llorens Villar, Yanire; Tusell Palmer, Fernando Jorge ; Canut Blasco, Andrés; Barrasa González, Helena; Corral, Esther; Martín, Alejandro; Rodríguez Gascón, Alicia (Oxford University Press, 2019-05-07)Objectives: The aim of this study was to compare antimicrobial susceptibility rates in a Spanish ICU before and after the introduction of selective digestive decontamination (SDD) and also to compare these with susceptibility ... -
Augmented Renal Clearance in Critically Ill Patients: A Systematic Review
Bilbao Meseguer, Idoia; Rodríguez Gascón, Alicia; Barrasa González, Helena; Isla Ruiz, Arantxazu ; Solinís Aspiazu, María Ángeles (Springer, 2018-02-13)Background Traditionally, renal function in critically ill patients has been assessed to identify renal dysfunction, and dose adjustment is generally accepted in such a context. Nevertheless, augmented renal clearance ... -
Efecto de las técnicas continuas de reemplazo renal y del aclaramiento renal aumentado en el comportamiento famacocinético/farmacodinámico de linezolid en pacientes críticos.
Barrasa González, Helena (2019-10-11)La sepsis grave sigue siendo una importante causa de morbi-mortalidad en las unidades de cuidados intensivos. La piedra angular del tratamiento de la infección es el inicio precoz de un tratamiento antibiótico adecuado y ... -
Impact of augmented renal clearance on the pharmacokinetics of linezolid: Advantages of continuous infusion from a pharmacokinetic/pharmacodynamic perspective
Barrasa González, Helena; Soraluce Olañeta, Amaia; Usón, Elena; Sainz, Javier; Martín, Alejandro; Sánchez Izquierdo, José Ángel; Maynar, Javier; Rodríguez Gascón, Alicia; Isla Ruiz, Arantxazu (Elsevier, 2020-04)Objectives: The aim of this study was to assess the influence of renal function, in particular the presence of augmented renal clearance (ARC), on the pharmacokinetics of linezolid in critically ill patients. The effect ... -
Novel Population Pharmacokinetic Model for Linezolid in Critically Ill Patients and Evaluation of the Adequacy of the Current Dosing Recommendation
Soraluce Olañeta, Amaia; Barrasa González, Helena; Asín-Prieto, Eduardo; Sánchez Izquierdo, José Ángel; Maynar, Javier; Isla Ruiz, Arantxazu ; Rodríguez Gascón, Alicia (MDPI, 2020-01-09)Antimicrobial treatment in critically ill patients remains challenging. The aim of this study was to develop a population pharmacokinetic model for linezolid in critically ill patients and to evaluate the adequacy of ... -
Optimization of levetiracetam dosing regimen in critically ill patients with augmented renal clearance: a Monte Carlo simulation study
Bilbao Meseguer, Idoia; Barrasa González, Helena; Rodríguez Gascón, Alicia; Asín-Prieto, Eduardo; Maynar, Javier; Sánchez Izquierdo, José Ángel; Solinís Aspiazu, María Ángeles ; Isla Ruiz, Arantxazu (BMC, 2022-04)[EN] Background Levetiracetam pharmacokinetics is extensively altered in critically ill patients with augmented renal clearance (ARC). Consequently, the dosage regimens commonly used in clinical practice may not be sufficient ... -
Population pharmacokinetics of daptomycin in critically ill patients
Soraluce Olañeta, Amaia; Asín-Prieto, Eduardo; Rodríguez Gascón, Alicia; Barrasa González, Helena; Maynar, Javier; Carcelero, Esther; Soy, Dolors; Isla Ruiz, Arantxazu (Elsevier, 2018-03-20)Daptomycin has shown activity against a wide range of Gram-positive bacteria; however, the approved dosages usually seem insufficient for critically ill patients. The aim of this study was to develop a population pharmacokinetic ... -
Population Pharmacokinetics of Levetiracetam and Dosing Evaluation in Critically Ill Patients with Normal or Augmented Renal Function
Bilbao-Meseguer, Idoia; Barrasa González, Helena; Asín-Prieto, Eduardo; Alarcia Lacalle, Ana; Rodríguez Gascón, Alicia; Maynar, Javier; Sánchez-Izquierdo, José Ángel; Balziskueta Flórez, Goiatz; Sánchez-Bayton Griffith, María; Quilez Trasobares, Nerea; Solinís Aspiazu, María Ángeles ; Isla Ruiz, Arantxazu (MDPI, 2021-10-15)Levetiracetam is a broad-spectrum antiepileptic drug commonly used in intensive care units (ICUs). The objective of this study is to evaluate the adequacy of levetiracetam dosing in patients with normal or augmented renal ... -
Pseudomonas aeruginosa Susceptibility in Spain: Antimicrobial Activity and Resistance Suppression Evaluation by PK/PD Analysis
Valero Telleria, Ana; Rodríguez Gascón, Alicia; Isla Ruiz, Arantxazu ; Barrasa González, Helena; Del Barrio Tofiño, Ester; Oliver, Antonio; Canut Blasco, Andrés; Solinís Aspiazu, María Ángeles (MDPI, 2021-11-08)Pseudomonas aeruginosa remains one of the major causes of healthcare-associated infection in Europe; in 2019, 12.5% of invasive isolates of P. aeruginosa in Spain presented combined resistance to ≥3 antimicrobial groups. ... -
Quantification of Ceftaroline in Human Plasma Using High-Performance Liquid Chromatography with Ultraviolet Detection: Application to Pharmacokinetic Studies
Alarcia Lacalle, Ana; Barrasa González, Helena; Maynar, Javier; Canut Blasco, Andrés; Gómez González, Carmen; Solinís Aspiazu, María Ángeles ; Isla Ruiz, Arantxazu ; Rodríguez Gascón, Alicia (MDPI, 2021-06-25)This study was conducted to develop a rapid, simple and reproducible method for the quantification of ceftaroline in plasma samples by high-performance liquid chromatography with ultraviolet detection (HPLC-UV). Sample ...