BackBrowsing by Author "Barrio Olano, María Rosa"
Now showing items 1-17 of 17
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Development of biotin-based strategies to dissect the ubiquitin code.
(2022-12-15)La naturaleza dinámica y reversible de las modificaciones post-traduccionales por parte de los miembros de la familia de la ubiquitina plantea importantes desafíos durante su investigación. En esta Tesis presentamos dos ... -
Estudio de la interacción de SALL1, causante del Síndrome de Townes-Brocks, con la E3 SUMO ligasa CBX4.
(2020-12-15)[ES] SALL1 es un represor transcripcional del tipo dedos de zinc que regula la organogénesis y el desarrollo animal. Las proteínas de la familia SALL sufren modificaciones postraduccionales por miembros de la familia de ... -
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Izeta Permisán, Ander
; ; ; ; ; ; ; Martínez Chantar, María Luz ; ; ; ; ; ; ; ; Carracedo Pérez, Arkaitz ; ; (The American Society for Clinical Investigation, 2020-07-01)
Cancer cells can develop a strong addiction to discrete molecular regulators, which control the aberrant gene expression programs that drive and maintain the cancer phenotype. Here, we report the identification of the ... -
Identification of proximal SUMO-dependent interactors using SUMO-ID
Barroso Gomila, Orhi; Trulsson, Erik; Muratore, Verónica; Canosa, Iñigo; Merino Cacho, Laura; Cortázar, Ana Rosa; Pérez Fernández, Coralia; ; Iloro, Ibon; Carracedo Pérez, Arkaitz; Aransay Bañares, Ana María; ; Mayor Martínez, Ugo ; Verteegal, Alfred C.O.; Barrio Olano, María Rosa; Sutherland, James D. (Nature Research, 2021-11-18)
[EN]The fast dynamics and reversibility of posttranslational modifications by the ubiquitin family pose significant challenges for research. Here we present SUMO-ID, a technology that merges proximity biotinylation by ... -
Integrative Analysis of Transcriptomics and Clinical Data Uncovers the Tumor- Suppressive Activity of MITF in Prostate Cancer
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Carracedo Pérez, Arkaitz; (Nature Publishing Group, 2018-10-11)
The dysregulation of gene expression is an enabling hallmark of cancer. Computational analysis of transcriptomics data from human cancer specimens, complemented with exhaustive clinical annotation, provides an opportunity ... -
LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton
Bozal Basterra, Laura; González Santamarta, María; Muratore, Verónica; Martín Martín, Natalia; Ercilla Eguiarte, Amaia; Rodríguez Pérez, José Antonio; Carracedo Pérez, Arkaitz ; Sutherland, James D.; Barrio Olano, María Rosa (Frontiers Media, 2021-04-01)
LUZP1 is a centrosomal and actin cytoskeleton-localizing protein that regulates both ciliogenesis and actin filament bundling. As the cytoskeleton and cilia are implicated in metastasis and tumor suppression, we examined ... -
Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis
; ; ; ; ; ; ; ; ; ; ; ; Arizmendi Bastarrika, Jesús María; ; ; ; Ávila, Matías A. ; Bañales Asurmendi, Jesús María ; ; ; ; ; ; ; Mayor Martínez, Ugo ; Martínez Chantar, María Luz ; (MDPI, 2020-11-27)
Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological ... -
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis
; ; ; ; ; ; ; ; ; ; ; ; ; Buqué García, Xabier; ; ; ; ; ; Bañales Asurmendi, Jesús María ; Ávila, Matías A. ; ; ; ; ; Mayor Martínez, Ugo ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-06-18)
[EN] Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic ... -
Post-translational modifications by sumo and ubiquitin-like proteins; role of sumoylation on sall proteins
(2016-02-18)Las modificaciones post-traduccional debidas a la conjugación de Ubiquitina y de proteínas similares a la Ubiquitina (UbLs) contribuyen a extender y diversificar la funcionalidad de los proteomas eucariotas. SUMO (Small ... -
Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells
Ramírez Sánchez, Juan Manuel; Martínez Zárate, Aitor; Lectez, Benoit; Lee, So Young; Franco, Maribel; Barrio Olano, María Rosa; Dittmar, Gunnar; Mayor Martínez, Ugo (Public Library Science, 2015-10-13)
Background Ubiquitination is known to regulate physiological neuronal functions as well as to be involved in a number of neuronal diseases. Several ubiquitin proteomic approaches have been developed during the last ... -
Proteostasis and Rare Diseases: Congenital Erythropoietic Porphyria and Townes-Brocks Syndrome
(2020-07-28)El término proteostasis se refiere a todos aquellos procesos biológicos críticos para el buen funcionamiento de la célula. La alteración de las vías reguladoras de la proteostasis puede afectar seriamente la función celular ... -
SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes
; ; ; ; ; ; ; ; ; ; ; Rodríguez Pérez, José Antonio; ; ; (Frontiers Media, 2021-09-21)
Development is orchestrated through a complex interplay of multiple transcription factors. The comprehension of this interplay will help us to understand developmental processes. Here we analyze the relationship between ... -
SUMOylation in the control of cholesterol homeostasis
Talamillo, Ana; Ajuria, Leiore; Grillo, Marco; Barroso Gomila, Orhi; Mayor Martínez, Ugo; Barrio Olano, María Rosa (The Royal Society, 2020-05)
SUMOylation-protein modification by the small ubiquitin-related modifier (SUMO)-affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates. ... -
Targeting PML in triple negative breast cancer elicits growth suppression and senescence
Arreal López, Leire; Piva, Marco; Fernández Ruiz, Sonia; Revandkar, Ajinkya; Schaub Clerigué, Ariane; Villanueva, Josep; Zabala Letona, Amaia; Pujana Vaquerizo, Mikel; Astobiza Pérez, Ianire; Cortázar, Ana Rosa; Hermanova, Ivana; Bozal Basterra, Laura; Arruabarrena Aristorena, Amaia; Crespo, Jana R.; Valcárcel Jiménez, Lorea; Zuñiga García, Patricia; Canals, Francesc; Torrano Moya, Verónica; Barrio Olano, María Rosa; Sutherland, James D.; Alimonti, Andrea; Martín Martín, Natalia; Carracedo Pérez, Arkaitz (Nature, 2020-04)
Oncogene addiction postulates that the survival and growth of certain tumor cells is dependent upon the activity of one oncogene, despite their multiple genetic and epigenetic abnormalities. This phenomenon provides a ... -
The role of primary cilia in Townes-Brocks Syndrome
(2019-02-01)El Síndrome de Townes-Brocks (TBS1, MIM 107480 ) está causado por mutaciones en el gen SALL1, dando lugar, en la mayoría de los casos, a una proteína truncada. TBS se caracteriza por un espectro de malformaciones en dedos, ... -
The role of SUMOylation during development
Talamillo, Ana; Barroso Gomila, Orhi; Giordano, Immacolata; Ajuria, Leiore; Grillo, Marco; Mayor Martínez, Ugo; Barrio Olano, María Rosa (Portland Press, 2020-04)
During the development of multicellular organisms, transcriptional regulation plays an important role in the control of cell growth, differentiation and morphogenesis. SUMOylation is a reversible post-translational process ... -
Zilio primarioaren formakuntza akatsak Townes-Brocks sindromean/ Defectos en la formación del cilio primario en el síndrome de Townes-Brocks
(2017-01-10)La proteína SALL1 es un factor de transcripción localizado en el núcleo. En este trabajo además se ha demostrado una novedosa localización ciliar de la proteína. Mutaciones en el gen SALL1 que codifican proteínas truncadas ...