BackBrowsing by Author "Bizkarguenaga, Maider"
Now showing items 1-6 of 6
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Arachidyl Amido Cholanoic Acid Improves Liver Glucose and Lipid Homeostasis in Nonalcoholic Steatohepatitis Via AMPK and mTOR Regulation
Fernández Ramos, David; Lopitz Otsoa, Fernando; De la Cruz Villar, Laura; Bilbao García, Jon; Pagano, Martina; Mosca, Laura; Bizkarguenaga, Maider; ; ; Iruarrizaga Lejarreta, Marta; Sot, Jesús; Tsvirkun, Darya; Van Liempd, Sebastiaan Martijn; Goñi Urcelay, Félix María
; Alonso, Cristina; Martínez Chantar, María Luz ; ; Hayardeny, Liat; Lu, Shelly C.; Mato, José M. (Baishideng, 2020-09-14)
BACKGROUND Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. ... -
Magnesium Accumulation Upon Cyclin M4 Silencing Activates Microsomal Triglyceride Transfer Protein Improving NASH
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-07)
Background & Aims: Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg2+ across cell membranes. Herein, ... -
Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Martínez de Marigorta Izaga, Edorta; ; ; ; ; ; ; ; ; ; Bañales Asurmendi, Jesús María ; ; ; ; ; ; ; ; ; ; (Wiley, 2022-10)
Background and Aims We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we align metabolomic signatures with cardiovascular disease (CVD) and genetic risk factors. Approach and ... -
Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals
Goikoetxea Usandizaga, Naroa; ; Delgado, Teresa C.; Simón Espinosa, Jorge; Fernández Ramos, David; Barriales, Diego; Cornide, María E.; Jiménez, Mónica; Pérez Redondo, Marina; Lachiondo Ortega, Sofía; Rodríguez Agudo, Rubén; Bizkarguenaga, Maider; Diego Zalamea, Juan; Pasco, Samuel T.; Caballero Díaz, Daniel; Alfano, Benedetta; Bravo Garmendia, Miren; González Recio, Irene; Mercado Gómez, María; Gil Pitarch, Clàudia; Mabe Alvarez, Jon; Gracia Sancho, Jordi; Abecia Aliende, Leticia; Lorenzo, Oscar; Martín Sanz, Paloma; Abrescia, Nicola A.G.; Sabio, Guadalupe; Rincón, Mercedes; Anguita Castillo, Juan de Dios; Miñambres, Eduardo; Martín, César; Berenguer, Marina; Fabregat, Isabel; Casado, Marta; Peralta, Carmen; Varela Rey, Marta; Martínez Chantar, María Luz (Wiley, 2022-03)
[EN] Background and Aims Hepatic ischemia-reperfusion injury (IRI) is the leading cause of early posttransplantation organ failure as mitochondrial respiration and ATP production are affected. A shortage of donors has ... -
Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis
; ; ; ; ; ; ; ; ; ; ; ; Arizmendi Bastarrika, Jesús María; ; ; ; Ávila, Matías A. ; Bañales Asurmendi, Jesús María ; ; ; ; ; ; ; Mayor Martínez, Ugo ; Martínez Chantar, María Luz ; (MDPI, 2020-11-27)
Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological ... -
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis
; ; ; ; ; ; ; ; ; ; ; ; ; Buqué García, Xabier; ; ; ; ; ; Bañales Asurmendi, Jesús María ; Ávila, Matías A. ; ; ; ; ; Mayor Martínez, Ugo ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-06-18)
[EN] Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic ...