Browsing by Author "Choi, Philip H."
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CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase
López Alonso, Jorge Pedro; Lázaro, Melisa; Gil Cartón, David; Choi, Philip H.; Dodu, Alexandra; Tong, Liang; Valle Rodríguez, Mikel Karmel (Nature, 2022-10)Pyruvate carboxylase (PC) is a tetrameric enzyme that contains two active sites per subunit that catalyze two consecutive reactions. A mobile domain with an attached prosthetic biotin links both reactions, an initial biotin ...