Listar por autor "De Cózar Ruano, Abel"
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Additive and Emergent Catalytic Properties of Dimeric Unnatural Amino Acid Derivatives: Aldol and Conjugate Additions.
Retamosa Hernández, María de Gracia; Ruiz Olalla, Andrea; Agirre Goikoetxeaundia, Maddalen; De Cózar Ruano, Abel; Bello, Tamara; Cossío Mora, Fernando Pedro (Wiley, 2021-11-11)[EN]Different densely substituted L- and D-proline esters were prepared by asymmetric (3+2) cycloaddition reactions catalyzed by conveniently selected EhuPhos chiral ligands. The gamma-nitro-2-alkoxycarbonyl pyrrolidines ... -
Catalysis of a 1,3-dipolar reaction by distorted DNA incorporating a heterobimetallic platinum(II) and copper(II) complex
Rivilla de la Cruz, Iván ; De Cózar Ruano, Abel; Schäfer, Thomas ; Hernandez, Frank J.; Bittner, Alexander J.; Eleta-Lopez, Aitziber; Aboudzadeh, Ali ; Santos, José I.; Miranda, José I.; Cossío Mora, Fernando Pedro (Royal Society of Chemistry, 2017-08-11)A novel catalytic system based on covalently modified DNA is described. This catalyst promotes 1,3-dipolar reactions between azomethine ylides and maleimides. The catalytic system is based on the distortion of the double ... -
Chiral gold(I) vs chiral silver complexes as catalysts for the enantioselective synthesis of the second generation GSK-hepatitis C virus inhibitor
Martín Rodríguez, María; Nájera, Carmen; Sansano, José M.; De Cózar Ruano, Abel; Cossío Mora, Fernando Pedro (Beilstein Institut, 2011-07)The synthesis of a GSK 2(nd) generation inhibitor of the hepatitis C virus, by enantioselective 1,3-dipolar cycloaddition between a leucine derived iminoester and tert-butyl acrylate, was studied. The comparison between ... -
Chiral self-recognition in a bispericyclic cyclodimerisation reaction of 1-azadienes
López Francés, Adrián; Del Corte Solaguren-Beascoa, Xabier; Serna Burgos, Zuriñe ; De los Santos Ruiz, Jesús Manuel ; De Cózar Ruano, Abel; Vicario Hernando, Javier (RSC, 2023-10)Hermaphroditism of molecules: as in nature some species behave as male or female depending on the environment, herein we report a bispericyclic dimerisation of cyclic 1-azadienes where a molecule can behave as either diene ... -
Dehydration of alcohols catalyzed by copper(ii) sulfate: type II dyotropic reactions and stepwise mechanisms
Sánchez Quesada, Jorge; López Cruz, Carlos; De Cózar Ruano, Abel; Arrieta Ayestarán, Ana Jesús; Arrastia Basalo, Miren Iosune; Cossío Mora, Fernando Pedro (RSC, 2024)Dehydration of alcohols in the presence of copper(II) sulfate has been analyzed computationally. Density functional theory (DFT) calculations on selected alcohols indicate that this reaction can take place via two possible ... -
Exploring the Reactivity of Rigid 1-Azadienes Derived from Methylene γ-Lactams. Applications to the Stereoselective Synthesis of Spiro-γ-Lactams
López Francés, Adrián; Serna Burgos, Zuriñe ; Del Corte Solaguren-Beascoa, Xabier; De los Santos Ruiz, Jesús Manuel ; De Cózar Ruano, Abel; Vicario Hernando, Javier (ACS, 2024-06)A study on the reactivity of rigid 1-azadienes derived from methylene γ-lactams is reported. Through the functionalization of 1-amino α,β-unsaturated γ-lactam derivatives, easily available from a multicomponent reaction ... -
Higher-Order Electrocyclizations in Biological and Synthetic Processes
De Cózar Ruano, Abel; Arrieta Ayestarán, Ana Jesús; Arrastia Basalo, Miren Iosune; Cossío Mora, Fernando Pedro (Wiley, 2023-11)In general, electrocyclizations follow the Woodward-Hoffmann's rules of conservation of orbital symmetry. These rules have been extensively verified in low-order processes, both in thermal and photochemical reactions, up ... -
Nature of Alkali- and Coinage-Metal Bonds Versus Hydrogen Bonds
Larrañaga Agirre, Olatz; Arrieta Ayestaran, Ana Jesús ; Fonseca Guerra, Célia; Bickelhaupt, F. Matthias; De Cózar Ruano, Abel (Wiley, 2021-01)We have quantum chemically studied the structure and nature of alkali- and coinage-metal bonds (M-bonds) versus that of hydrogen bonds between A-M and B- in archetypal [A-M center dot center dot center dot B](-) model ... -
Probing α‐Amino Aldehydes as Weakly Acidic Pronucleophiles: Direct Access to Quaternary α‐Amino Aldehydes by an Enantioselective Michael Addition Catalyzed by Brønsted Bases
García Urricelqui, Ane; De Cózar Ruano, Abel; Mielgo Vicente, María Antonia ; Palomo Nicolau, Claudio (Wiley, 2020-10-09)The high tendency of α-amino aldehydes to undergo 1,2-additions and their relatively low stability under basic conditions have largely prevented their use as pronucleophiles in the realm of asymmetric catalysis, particularly ... -
Radiationless mechanism of UV deactivation by cuticle phenolics in plants
González Moreno, Ana; De Cózar Ruano, Abel; Prieto Núñez Polo, María Pilar; Domínguez Carmona, Eva; Heredia, Antonio (Nature Research, 2022-04)[EN] Hydroxycinnamic acids present in plant cuticles, the interphase and the main protective barrier between the plant and the environment, exhibit singular photochemical properties that could allow them to act as a UV ... -
syn-Selective Michael reaction of α-branched aryl acetaldehydes with nitroolefins promoted by squaric amino acid derived bifunctional Brønsted bases
García Urricelqui, Ane; De Cózar Ruano, Abel; Campano García, Teresa Esperanza; Mielgo Vicente, María Antonia ; Palomo Nicolau, Claudio (Wiley, 2021-07-07)[EN] Here we describe a direct access to 2,2,3-trisubstituted syn γ-nitroaldehydes by addition of α-branched aryl acetaldehydes to nitroolefins promoted by a cinchona based squaric acid-derived amino acid peptide. Different ... -
Synergic photoprotection of phenolic compounds present in tomato fruit cuticle: a spectroscopic investigation in solution
González Moreno, Ana; Woolley, Jack M.; Domínguez Carmona, Eva; De Cózar Ruano, Abel; Heredia, Antonio; Stavros, Vasilios G. (Royal Society of Chemistry, 2023-05)Coumaric acids and flavonoids play pivotal roles in protecting plants against ultraviolet radiation (UVR) exposure. In this work, we focus our photoprotection studies on p-coumaric acid and the flavonoid naringenin ... -
Synthesis of β-Hydroxy α-Amino Acids Through Brønsted Base-Catalyzed syn-Selective Direct Aldol Reaction of Schiff Bases of Glycine o-Nitroanilide
Vera Salas, Silvia; Vázquez, Ana; Rodríguez Urretavizcaya, Ricardo; Del Pozo, Sandra; Urruzuno Guiu, Iñaki; De Cózar Ruano, Abel; Mielgo Vicente, María Antonia ; Palomo Nicolau, Claudio (ACS, 2021-05-16)Here we report the highly enantio- and syn-selective synthesis of β-hydroxy α-amino acids from glycine imine derivatives under Brønsted base (BB) catalysis. The key of this approach is the use of benzophenone-derived imine ... -
Synthetic scope and DFT analysis of the chiral binap-gold(I) complex-catalyzed 1,3-dipolar cycloaddition of azlactones with alkenes
Martín Rodríguez, María; Castelló, Luis M.; Nájera, Carmen; Sansano, José M.; Larrañaga Agirre, Olatz; De Cózar Ruano, Abel; Cossío Mora, Fernando Pedro (Beilstein Institut, 2013-11)he 1,3-dipolar cycloaddition between glycine-derived azlactones with maleimides is efficiently catalyzed by the dimeric chiral complex [(S-a)-Binap.AuTFA](2). The alanine-derived oxazolone only reacts with tert-butyl ...