Browsing by Author "Drenth, Joost P. H."

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      Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease 

      Lee-Law, Pui Y.; Olaizola Rebe, Paula; Caballero Camino, Francisco Javier ORCID; Izquierdo Sánchez, Laura; Rodrigues, Pedro M.; Perugorria Montiel, María Jesús; Azkargorta, Mikel; Elortza, Felix; Martínez Chantar, María Luz ORCID; Aspichueta Celaá, Patricia; Bujanda Fernández de Pierola, Luis ORCID; Drenth, Joost P. H.; Bañales Asurmendi, Jesús María ORCID (Sage, 2021-09)
      Background Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts, which are the main cause of morbidity. Previous studies revealed ...
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      Targeting UBC9-Mediated Protein Hyper-SUMOylation in Cystic Cholangiocytes Halts Polycystic Liver Disease in Experimental Models 

      Lee-Law, Pui Y.; Olaizola Rebe, Paula; Caballero Camino, Francisco Javier ORCID; Izquierdo Sánchez, Laura; Rodrigues, Pedro M.; Santos Laso, Álvaro; Azkargorta, Mikel; Elortza, Felix; Martínez Chantar, María Luz ORCID; Perugorria Montiel, María Jesús; Aspichueta Celaá, Patricia; Marzioni, Marco; LaRusso, Nicholas F.; Bujanda Fernández de Pierola, Luis ORCID; Drenth, Joost P. H.; Bañales Asurmendi, Jesús María ORCID (Elsevier, 2021-02)
      BACKGROUND & AIMS: Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative genes participate in protein biogenesis and/or ...