Browsing by Author "Etxebarria, Aitor"
Now showing items 1-3 of 3
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Activity-associated effect of LDL receptor missense variants located in the cysteine-rich repeats
Etxebarria, Aitor; Benito Vicente, Asier; Stef, M.; Ostolaza Echabe, Elena Amaya; Palacios, Lourdes; Martín Plágaro, César Augusto (Elsevier, 2015-02)Background: The LDL receptor (LDLR) is a Class I transmembrane protein critical for the clearance of cholesterol-containing lipoprotein particles. The N-terminal domain of the LDLR harbours the ligand-binding domain ... -
Ca2+ Influx and Tyrosine Kinases Trigger Bordetella Adenylate Cyclase Toxin (ACT) Endocytosis. Cell Physiology and Expression of the CD11b/CD18 Integrin Major Determinants of the Entry Route
Belloso Uribe, Kepa; Martín Plágaro, César Augusto; Etxebarria, Aitor; González Bullón, David; Gómez Bilbao, Geraxane; Ostolaza Echabe, Elena Amaya (Public Library Publishing, 2013-09)
Humans infected with Bordetella pertussis, the whooping cough bacterium, show evidences of impaired host defenses. This pathogenic bacterium produces a unique adenylate cyclase toxin (ACT) which enters human phagocytes and ... -
Calpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain
Belloso Uribe, Kepa; Etxebarria, Aitor; Martín Plágaro, César Augusto; Ostolaza Echabe, Elena Amaya (Public Library Publishing, 2013-06)Bordetella pertussis, the whooping cough pathogen, secretes several virulence factors among which adenylate cyclase toxin (ACT) is essential for establishment of the disease in the respiratory tract. ACT weakens host ...