BackBrowsing by Author "Falcón Pérez, Juan Manuel"
Now showing items 1-12 of 12
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A Comprehensive Study of Vesicular and Non-Vesicular miRNAs from a Volume of Cerebrospinal Fluid Compatible with Clinical Practice
; ; ; ; ; Santos Zorrozúa, Borja
; ; ; ; ; García-Orad Carles, África ; (Ivyspring International Publisher, 2019)
Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field ... -
A Novel Approach on the Use of Samples from Faecal Occult Blood Screening Kits for Metabolomics Analysis: Application in Colorectal Cancer Population
Albóniga Díez, Oihane Elena; ; Bujanda Fernández de Pierola, Luis ; ; ; ; ; (MDPI, 2023-02-21)
The incidence of colorectal cancer (CRC) is increasing, and currently it is the third most common cancer. Early CRC diagnosis is still difficult and relies on an invasive colonoscopy and tissue biopsy. The globally observed ... -
Extracellular vesicles from hair follicle-derived mesenchymal stromal cells: isolation, characterization and therapeutic potential for chronic wound healing
Las Heras Zapata, Kevin; Royo, Félix; García Vallicrosa, Clara; Igartua Olaechea, Manuela; Santos Vizcaíno, Edorta ; Falcón Pérez, Juan Manuel; Hernández Martín, Rosa María (BMC, 2022-04)
[EN] Background Mesenchymal stromal cells (MSCs) and their extracellular vesicles (MSC-EVs) have demonstrated to elicit immunomodulatory and pro-regenerative properties that are beneficial for the treatment of chronic ... -
Free and extracellular vesicle-associated microRNAs from endometrial fluid as noninvasive diagnostic biomarkers of implantative endometrium
(2022-12-20)Reproducción asistida. Se trata de un proceso complejo, que requiere una sincronía entre el desarrollo delembrión y el endometrio, pero también, una adecuada comunicación entre ambos. Los microRNAs(miRNAs) y las vesículas ... -
Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia
; ; ; Abecia Aliende, Leticia; ; ; ; ; ; ; ; ; ; ; ; ; Bujanda Fernández de Pierola, Luis ; ; ; ; ; (Elsevier, 2019-08)
Background: Fibromyalgia is a complex, relatively unknown disease characterised by chronic, widespread musculoskeletal pain. The gut-brain axis connects the gut microbiome with the brain through the enteric nervous system ... -
Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression
; ; ; ; ; ; ; ; ; ; ; ; ; ; Carracedo Pérez, Arkaitz; (Taylor & Francis, 2018-05-07)
Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have ... -
Metabolic implications and characterization of hepatic extracellular vesicles in drug-induced liver injury
(2015-07-28)El daño hepático inducido por drogas (DILI) es un grave problema en las sociedadesdesarrolladas, siendo el responsable de más del 50% de los casos de fallo hepático agudo. Unárea de gran interés, tanto en el diagnóstico ... -
microRNA-based signatures obtained from endometrial fluid identify implantative endometrium
; ; ; ; ; ; ; ; ; ; ; ; ; ; Subirán Ciudad, Nerea; ; (Oxford University Press, 2022-10)
STUDY QUESTION Is it possible to use free and extracellular vesicle-associated microRNAs (miRNAs) from human endometrial fluid (EF) samples as non-invasive biomarkers for implantative endometrium? SUMMARY ANSWER The free ... -
Multi-omics integration for biomarker discovery
(2019-12-19)Los estudios de identificación de nuevos biomarcadores reciben una cantidad notable de financiación, pero su éxito es reducido, con solo un 0.1% de los nuevos biomarcadores identificados llegando a implantarse en la práctica ... -
Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Bujanda Fernández de Pierola, Luis; ; Andersen, Jesper B.; ; ; Bañales Asurmendi, Jesús María (MDPI, 2020-03-14)
Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis (PSC) is a risk factor. Non-invasive diagnosis ... -
Repurposing ciclopirox as a pharmacological chaperone active against congenital erythropoietic porphyria.
(2018-10-19)La porfiria eritropoyética congénita es una enfermedad rara autosómica recesiva producida por una actividad deficiente en la uroporfirinógeno III sintasa, la cuarta enzima de la ruta biosintética del grupo hemo. La enfermedad ... -
Variability in cerebrospinal fluid microRNAs through life
; López López, Elixabet; ; ; ; ; ; ; ; García-Orad Carles, África (Springer, 2020-07-16)
The development of human brain starts in the first weeks of embryo differentiation. However, there are many relevant neurodevelopmental processes that take place after birth and during lifespan. Such a fine and changing ...