Browsing by Author "Knudsen, Birgitta R."
Now showing items 1-5 of 5
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Gel-Free Tools for Quick and Simple Screening of Anti-Topoisomerase 1 Compounds
Keller, Josephine Geertsen; Petersen, Kamilla Vandsø; Mizielinski, Karol; Thiesen, Celine; Bjergbæk, Lotte; Reguera, Rosa M.; Pérez-Pertejo, Yolanda; Balaña-Fouce, Rafael; Trejo, Ángela; Masdeu Margalef, Carme; Alonso Pérez, Concepción Estibaliz ; Knudsen, Birgitta R.; Tesauro, Cinzia (MDPI, 2023-04-27)With the increasing need for effective compounds against cancer or pathogen-borne diseases, the development of new tools to investigate the enzymatic activity of biomarkers is necessary. Among these biomarkers are DNA ... -
Novel phosphine sulphide gold(I) complexes: topoisomerase I inhibitors and antiproliferative agents
Martín Encinas, Endika; Cornejo Rodríguez, Verónica; Miguel, Jesús Ángel; Martinez-Ilarduya, Jesus M.; Rubiales Alcaine, María Gloria ; Knudsen, Birgitta R.; Palacios Gambra, Francisco Javier ; Alonso Pérez, Concepción Estibaliz (RSC, 2020-05-20)This work describes the synthesis of the gold(I) complexes of phosphine sulphides. The formation of these new derivatives has been confirmed by X-ray crystallography. The coordination of gold(I) with the sulphur atom of ... -
Straightforward synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents of hybrid Chromeno[4,3-b][1,5] Naphthyridines and Chromeno[4,3-b][1,5]Naphthyridin-6-ones
Martín Encinas, Endika; Rubiales Alcaine, María Gloria ; Knudsen, Birgitta R.; Palacios Gambra, Francisco Javier ; Alonso Pérez, Concepción Estibaliz (Elsevier, 2019-06-14)This work describes the synthesis of hybrid tetrahydro-1,5-naphthyridine and 1,5-naphthyridine derivatives fused with heterocycles such as chromenes and chromen-2-ones or coumarins, which were synthesized in good to high ... -
Synthesis of hybrid phosphorated indenoquinolines and biological evaluation as topoisomerase I inhibitors and antiproliferative agents
Fuertes Sánchez, María ; Selas Lanseros, Asier; Trejo, Ángela; Knudsen, Birgitta R.; Palacios Gambra, Francisco Javier ; Alonso Pérez, Concepción Estibaliz (Elsevier, 2022-02-01)[EN]This work describes the first synthesis of diethyl 6,6a,7,11b-tetrahydro-5H-indeno[2,1-c]quinolinylphosphonates 5, diethyl 7H-indeno[2,1-c]quinolinylphosphonates 6 and diethyl 7-oxo-7H-indeno[2,1-c]quinolinylphosphonates ... -
Synthesis of novel hybrid quinolino[4,3-b][1,5]naphthyridines and quinolino[4,3-b][1,5]naphthyridin-6(5H)-one derivatives and biological evaluation as topoisomerase I inhibitors and antiproliferatives
Martín Encinas, Endika; Selas Lanseros, Asier; Tesauro, Cinzia; Rubiales Alcaine, María Gloria ; Knudsen, Birgitta R.; Palacios Gambra, Francisco Javier ; Alonso Pérez, Concepción Estibaliz (Elsevier, 2020-04-03)The topoisomerase I enzymatic inhibition of hybrid quinolino [4,3-b] (Siegel et al., 2013; Antony et al., 2003) [1,5]naphthyridines and quinolino [4,3-b] (Siegel et al., 2013; Antony et al., 2003) [1,5]naphthyridin-6(5H)-ones ...