BackBrowsing by Author "Knudsen, Birgitta Ruth"
Now showing items 1-3 of 3
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A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors
; ; ; ; Palacios Gambra, Francisco Javier
; Alonso Pérez, Concepción Estibaliz ; ; (MDPI, 2021-07-15)
DNA sensors can be used as robust tools for high-throughput drug screening of small molecules with the potential to inhibit specific enzymes. As enzymes work in complex biological pathways, it is important to screen for ... -
Hybrid Quinolinyl Phosphonates as Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation against Topoisomerase 1B (TOP1B)
Selas Lanseros, Asier; Fuertes Sánchez, María; Melcón-Fernández, Estela; Pérez-Pertejo, Yolanda; Reguera, Rosa M.; Balaña-Fouce, Rafael; Knudsen, Birgitta Ruth; Palacios Gambra, Francisco Javier ; Alonso Pérez, Concepción Estibaliz (MDPI, 2021-08-09)
This work describes, for the first time, the synthesis of dialkyl (2-arylquinolin-8-yl)phosphonate derivatives. The preparation was carried out through a direct and simple process as a multicomponent Povarov reaction of ... -
Simple and Fast DNA Based Sensor System for Screening of Small-Molecule Compounds Targeting Eukaryotic Topoisomerase 1
Petersen, Kamilla Vandsø; Selas Lanseros, Asier; Hymøller, Kirstine Mejlstrup; Mizielinski, Karol; Thorsager, Maria; Stougaard, Magnus; Alonso Pérez, Concepción Estibaliz; Palacios Gambra, Francisco Javier ; Pérez-Pertejo, Yolanda; Reguera, Rosa M.; Balaña-Fouce, Rafael; Knudsen, Birgitta Ruth; Tesauro, Cinzia (MDPI, 2021-08-13)
Background: Eukaryotic topoisomerase 1 is a potential target of anti-parasitic and anti-cancer drugs. Parasites require topoisomerase 1 activity for survival and, consequently, compounds that inhibit topoisomerase 1 activity ...