Browsing by Author "Kunert, Renate"
Now showing items 1-2 of 2
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Confocal microscopy of giant vesicles supports the absence of HIV-1 neutralizing 2F5 antibody reactivity to plasma membrane phospholipids
Apellaniz Unzalu, Beatriz ; García Sáez, Ana J.; Huarte Arrayago, Nerea; Kunert, Renate; Vorauer-Uhl, Karola; Katinger, Hermann; Schwille, Petra; Nieva Escandón, José Luis (Elsevier, 2010-03-17)The broadly neutralizing anti-HIV-1 2F5 monoclonal antibody recognizes a gp41 epitope proximal to the viral membrane. Potential phospholipid autoreactivity at cell surfaces has raised concerns about the use of this antibody ... -
Recognition of Membrane-Bound Fusion-Peptide/MPER Complexes by the HIV-1 Neutralizing 2F5 Antibody : Implications for Anti-2F5 Immunogenicity
Huarte Arrayago, Nerea; Araujo Pasarín, Aitziber; Arranz, Rocio; Lorizate Nogales, Maier; Quendler, Heribert; Kunert, Renate; Valpuesta, José M.; Nieva Escandón, José Luis (Public Library of Science, 2012-12-21)The membrane proximal external region (MPER) of the fusogenic HIV-1 glycoprotein-41 harbors the epitope sequence recognized by 2F5, a broadly neutralizing antibody isolated from an infected individual. Structural mimicry ...