Browsing by Author "Nairn, Angus C."

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      Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61) levels 

      Xu, Jian; Kurup, Pradeep; Azkona Mendoza, Garikoitz ORCID; Baguley, Tyler D.; Saavedra, Ana; Nairn, Angus C.; Ellman, Jonathan A.; Pérez Navarro, Esther; Lombroso, Paul J. (Wiley, 2015-08-28)
      Brain-derived neurotrophic factor (BDNF) regulates synaptic strengthening and memory consolidation, and altered BDNF expression is implicated in a number of neuropsychiatric and neurodegenerative disorders. BDNF potentiates ...
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      Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation 

      Madero-Pérez, Jesús; Fernández, Elena; Fernández, Belén; Lara Ordóñez, Antonio J.; Ramírez, Marian Blanca; Gómez-Suaga, Patricia; Waschbüsch, Dieter; Lobbestael, Evy; Baekelandt, Veerle; Nairn, Angus C.; Ruiz-Martínez, Javier; Aiastui, Ana; López de Munain Arregui, Adolfo José; Lis, Pawel; Comptdaer, Thomas; Taymans, Jean-Marc; Chartier-Harlin, Marie-Christine; Beilina, Alexandria; Gonnelli, Adriano; Cookson, Mark R.; Greggio, Elisa; Hilfiker, Sabine (Biomed Central, 2019-01-23)
      Background: Mutations in LRRK2 are a common genetic cause of Parkinson's disease (PD). LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a protein which has been implicated in various ...