Browsing by Author "Ward, Sophia"

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      Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal 

      Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Horswell, Stuart; Chambers, Tim; O'Brien, Tim; López Fernández de Villaverde, José Ignacio ORCID; Watkins, Thomas B. K.; Nicol, David; Stares, Mark; Challacombe, Ben; Hazell, Steve; Chandra, Ashish; Mitchell, Thomas J.; Au, Lewis; Eichler-Jonsson, Claudia; Jabbar, Faiz; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Archana Sinduri, Fernando; Stamp, Gordon; Nye, Emma; Stewart, Aengus; Xing, Wei; Smith, Jonathan C.; Escudero, Mickael; Huffman, Adam; Matthews, Nik; Elgar, Greg; Phillimore, Ben; Costa, Marta; Begum, Sharmin; Ward, Sophia; Salm, Max; Boeing, Stefan; Fisher, Rosalie; Spain, Lavinia; Navas, Carolina; Gronroos, Eva; Hobor, Sebastijan; Sharma, Sarkhara; Aurangzeb, Ismaeel; Lall, Sharanpreet; Polson, Alexander; Varia, Mary; Horsfield, Catherine; Fotiadis, Nicos; Pickering, Lisa; Schwarz, Roland F.; Silva, Bruno; Herrero, Javier; Luscombe, Nick M.; Jamal-Hanjani, Mariam; Rosenthal, Rachel; Birkbak, Nicolai J.; Wilson, Gareth A.; Pipek, Orsolya; Ribli, Dezso; Krzystanek, Marcin; Csabai, Istvan; Szállási, Zoltán; Gore, Martin E.; McGranahan, Nicholas; Van Loo, Peter; Campbell, Peter; Larkin, James; Swanton, Charles (Cell Press, 2018-04-19)
      The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, ...
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      Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts 

      Bortolomeazzi, Michele; Keddar, Mohamed Reda; Montorsi, Lucia; Acha-Sagredo, Amelia; Benedetti, Lorena; Temelkovski, Damjan; Choi, Subin; Petrov, Nedyalko; Todd, Katrina; Wai, Patty; Kohl, Johannes; Denner, Tamara; Nye, Emma; Goldstone, Robert; Ward, Sophia; Wilson, Gareth A.; Al Bakir, Maise; Swanton, Charles; John, Susan; Miles, James; Larijani, Banafshé ORCID; Kunene, Victoria; Fontana, Elisa; Arkenau, Hendrik-Tobias; Parker, Peter J.; Rodriguez-Justo, Manuel; Shiu, Kai-Keen; Spencer, Jo; Ciccarelli, Francesca D. (Elsevier, 2021-10)
      BACKGROUND & AIMS: Colorectal cancer (CRC) shows variable response to immune checkpoint blockade, which can only partially be explained by high tumor mutational burden (TMB). We conducted an integrated study of the cancer ...
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      Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal 

      Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Chambers, Tim; López Fernández de Villaverde, José Ignacio ORCID; Nicol, David; O'Brien, Tim; Larkin, James; Horswell, Stuart; Stares, Mark; Au, Lewis; Jamal-Hanjani, Mariam; Challacombe, Ben; Chandra, Ashish; Hazell, Steve; Eichler-Jonsson, Claudia; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Archana Sinduri, Fernando; Stamp, Gordon; Nye, Emma; Jabbar, Faiz; Spain, Lavinia; Lall, Sharanpreet; Guarch, Rosa; Falzon, Mary; Proctor, Ian; Pickering, Lisa; Gore, Martin E.; Watkins, Thomas B. K.; Ward, Sophia; Stewart, Aengus; DiNatale, Renzo; Becerra, Maria F.; Reznik, Ed; Hsieh, James J.; Richmond, Todd A.; Mayhew, George F.; Hill, Samantha M.; McNally, Catherine D.; Jones, Carol; Rosenbaum, Heidi; Stanislaw, Stacey; Burgess, Daniel L.; Alexander, Nelson R.; Swanton, Charles (Cell Press, 2018-04-19)
      Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with ...