BackExaminar por departamento (cas.) "Genética, antropología física y fisiología animal"
Now showing items 1-20 of 389
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1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death
; ; Ruiz Núñez, Asier
; ; Arrizabalaga Uriarte, Oskar ; ; Alberdi Alfonso, Elena María ; ; ; ; ; ; Zugaza Gurruchaga, José Luis (Nature Publishing Group, 2013-01)
1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ... -
18S rRNA V9 metabarcoding for diet characterization: a critical evaluation with two sympatric zooplanktivorous fish species
; Aguirre Rodrigo, Mikel; Abad García, David; Santos, María; Estomba Recalde, Miren Andone (Wiley Blackwell, 2016-03)
The potential of the 18S rRNA V9 metabarcoding approach for diet assessment was explored using MiSeq paired-end (PE; 2 9 150 bp) technology. To critically evaluate the method's performance with degraded/digested DNA, the ... -
A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression
(MDPI, 2022-03-21)The immune function is closely related to iron (Fe) homeostasis and allostasis. The aim of this bioinformatics-assisted review was twofold; (i) to update the current knowledge of Fe metabolism and its relationship to the ... -
A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K
García Santisteban, Iraia; ; ; Urbaneja Arrue, María Ángeles ; ; Bañuelos Rodríguez, Sonia ; Rodríguez Pérez, José Antonio (Springer Nature Switzerland AG, 2016-12)
The exportin CRM1 binds nuclear export signals (NESs), and mediates active transport of NES-bearing proteins from the nucleus to the cytoplasm. Structural and biochemical analyses have uncovered the molecular mechanisms ... -
A Comprehensive Study of Vesicular and Non-Vesicular miRNAs from a Volume of Cerebrospinal Fluid Compatible with Clinical Practice
; ; ; ; ; Santos Zorrozúa, Borja; ; ; ; ; García-Orad Carles, África ; (Ivyspring International Publisher, 2019)
Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field ... -
A Customized Pigmentation SNP Array Identifies a Novel SNP Associated with Melanoma Predisposition in the SLC45A2 Gene
; ; Alonso Alegre, Santos; Boyano López, María Dolores ; ; ; ; ; ; ; ; Izagirre Arribalzaga, Neskuts ; De la Rúa Vaca, Concepción ; Asumendi Mallea, Aintzane ; Pérez-Yarza Pérez-Irezabal, Gorka ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Public Library of Science, 2011-04-29)
As the incidence of Malignant Melanoma (MM) reflects an interaction between skin colour and UV exposure, variations in genes implicated in pigmentation and tanning response to UV may be associated with susceptibility to ... -
A Genome-Wide Study of Single-Nucleotide Polymorphisms in MicroRNAs and Further In Silico Analysis Reveals Their Putative Role in Susceptibility to Late-Onset Alzheimer's Disease.
; Santos Zorrozúa, Borja; ; ; Martínez de Pancorbo Gómez, María de los Angeles ; García-Orad Carles, África ; López López, Elixabet (Springer Nature, 2020-09-06)
Late-onset Alzheimer's disease (LOAD) is a neurodegenerative disorder of growing relevance in an aging society for which predictive biomarkers are needed. Many genes involved in LOAD are tightly controlled by microRNAs ... -
A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family
García Santisteban, Iraia; Bañuelos Rodríguez, Sonia ; Rodríguez Pérez, José Antonio (Portland Press LTD, 2012-01-01)
The mechanisms that regulate the nucleocytoplasmic localization of human deubiquitinases remain largely unknown. The nuclear export receptor CRM1 binds to specific amino acid motifs termed NESs (nuclear export sequences). ... -
A holo-omic approach towards a more sustainable broiler chicken production.
Marcos Basagoiti, Sofia (2024-02-23)
En esta tesis introduzco una perspectiva holo-ómica para estudiar las interacciones huésped-microbiota en pollos de engorde de producción intensiva en relación con el rendimiento. Informo de los resultados de 3 ensayos ... -
A human anti-M2 antibody mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and cytokine secretion by resting and cytokine preactivated natural killer (NK) cells
(Public Library of Science, 2015-04-27)The highly conserved matrix protein 2 (M2) is a good candidate for the development of a broadly protective influenza vaccine that induces long-lasting immunity. In animal models, natural killer (NK) cells have been proposed ... -
A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells
González Moro, Itziar; ; Sebastián de la Cruz, Maialen ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Frontiers Media, 2023-02)
IntroductionMost of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long ... -
A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health
Fernández Jiménez, Nora; ; Cilleros Portet, Ariadna ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Nature, 2022-11)
Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ ... -
A NKp80-based identification strategy reveals that CD56neg NK cells are not completely dysfunctional in health and disease.
Orrantia Robles, Ane; ; ; ; ; ; ; ; ; ; ; ; ; (Cell Press, 2020-07-01)
Natural killer (NK) cells are usually identified by the absence of other lineage markers, due to the lack of cell-surface-specific receptors. CD56neg NK cells, classically identified as CD56negCD16+, are very scarce in the ... -
A Novel Noninvasive Method Based on Salivary Inflammatory Biomarkers for the Screening of Celiac Disease
Sebastián de la Cruz, Maialen; ; ; ; ; Fernández Jiménez, Nora ; ; ; ; ; ; Irastorza Terradillos, Iñaki Xarles ; Bujanda Fernández de Pierola, Luis ; ; (Elsevier, 2021)
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A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation
(Nature Publishing Group, 2019-12)N6-methyladenosine (m6A) is the most common and abundant RNA modification. Recent studies have shown its importance in the regulation of several biological processes, including the immune response, and different approaches ... -
A Novel Transcriptome-Derived SNPs Array for Tench (Tinca Tinca L.)
; Langa Arranz, Jorge Eliseo; Montes Asperilla, Iratxe ; ; ; ; Estomba Recalde, Miren Andone (Public Library Science, 2019-03-19)
Tench (Tinca tinca L.) has great economic potential due to its high rate of fecundity and long-life span. Population genetic studies based on allozymes, microsatellites, PCR-RFLP and sequence analysis of genes and DNA ... -
A Novel, Noninvasive Method to Diagnose Active Eosinophilic Esophagitis, Combining Clinical Data and Oral Cavity RNA Levels
Sebastián de la Cruz, Maialen; ; ; ; Bujanda Fernández de Pierola, Luis ; (Elsevier, 2024-03)
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A Proteomic Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes
Ramírez Sánchez, Juan Manuel; Prieto Agujeta, Gorka ; ; ; ; Alduntzin Egizurain, Unai ; Osinalde Moraleja, Nerea ; ; ; ; Rodríguez Pérez, José Antonio ; ; ; ; ; Arizmendi Bastarrika, Jesús María ; Mayor Martínez, Ugo (MDPI, 2021-05-03)
The human genome contains nearly 100 deubiquitinating enzymes (DUBs) responsible for removing ubiquitin moieties from a large variety of substrates. Which DUBs are responsible for targeting which substrates remain mostly ... -
A real-time PCR assay to estimate invertebrate and fish predation on anchovy eggs in the Bay of Biscay
; ; ; ; ; ; Estomba Recalde, Miren Andone (Elsevier, 2014-12-12)
In order to investigate the role of predation on eggs and larvae in the recruitment of anchovy (Engraulis encrasicolus), sardine (Sardina pilchardus), sprat (Sprattus sprattus) and 52 macrozooplankton taxa were assayed for ... -
A Recording Form for Differential Diagnosis of Arthropathies
García Ventades, Nerea; Martín Laza, Imanol ; Hervella Afonso, Montserrat ; De la Rúa Vaca, Concepción (Elsevier, 2018-03)
The present study is focused on a group of arthropathies that may have very similar bone manifestations (rheumatoid arthritis, ankylosing spondylitis, reactive arthritis, psoriatic arthritis, osteoarthritis and diffuse ...