BackExaminar por departamento (cas.) "Genética, antropología física y fisiología animal"
Now showing items 1-20 of 237
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1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death
; ; Ruiz Núñez, Asier
; ; Arrizabalaga Uriarte, Oskar ; ; Alberdi Alfonso, Elena María ; ; ; ; ; Matute Almau, Carlos José ; Zugaza Gurruchaga, José Luis (Nature Publishing Group, 2013-01)
1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ... -
18S rRNA V9 metabarcoding for diet characterization: a critical evaluation with two sympatric zooplanktivorous fish species
Albaina Vivanco, Aitor; Aguirre Rodrigo, Mikel; Abad García, David; Santos, María; Estomba Recalde, Miren Andone (Wiley Blackwell, 2016-03)
The potential of the 18S rRNA V9 metabarcoding approach for diet assessment was explored using MiSeq paired-end (PE; 2 9 150 bp) technology. To critically evaluate the method's performance with degraded/digested DNA, the ... -
A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression
(MDPI, 2022-03-21)The immune function is closely related to iron (Fe) homeostasis and allostasis. The aim of this bioinformatics-assisted review was twofold; (i) to update the current knowledge of Fe metabolism and its relationship to the ... -
A Comprehensive Study of Vesicular and Non-Vesicular miRNAs from a Volume of Cerebrospinal Fluid Compatible with Clinical Practice
; ; ; ; ; Santos Zorrozúa, Borja; ; ; ; Benito Fernández, Francisco Javier ; ; (Ivyspring International Publisher, 2019)
Cerebrospinal fluid (CSF) microRNAs (miRNAs) have emerged as potential biomarkers for minimally invasive diagnosis of central nervous system malignancies. However, despite significant advances in recent years, this field ... -
A Customized Pigmentation SNP Array Identifies a Novel SNP Associated with Melanoma Predisposition in the SLC45A2 Gene
; ; Alonso Alegre, Santos; Boyano López, María Dolores ; ; ; ; ; ; ; ; Izagirre Arribalzaga, Neskuts ; De la Rúa Vaca, Concepción ; Asumendi Mallea, Aintzane ; Pérez-Yarza Pérez-Irezabal, Gorka ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Public Library of Science, 2011-04-29)
As the incidence of Malignant Melanoma (MM) reflects an interaction between skin colour and UV exposure, variations in genes implicated in pigmentation and tanning response to UV may be associated with susceptibility to ... -
A Novel Noninvasive Method Based on Salivary Inflammatory Biomarkers for the Screening of Celiac Disease
Sebastián de la Cruz, Maialen; ; ; ; ; Fernández Jiménez, Nora ; ; ; ; ; ; Irastorza Epelde, Igor ; Bujanda Fernández de Pierola, Luis ; Bilbao Catalá, José Ramón ; (Elsevier, 2021)
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A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation
; Santín Gómez, Izortze; ; ; Jauregi Miguel, Amaia ; ; Bilbao Catalá, José Ramón (Nature Publishing Group, 2019-12)
N6-methyladenosine (m6A) is the most common and abundant RNA modification. Recent studies have shown its importance in the regulation of several biological processes, including the immune response, and different approaches ... -
A Novel Transcriptome-Derived SNPs Array for Tench (Tinca Tinca L.)
; Langa Arranz, Jorge Eliseo; Montes Asperilla, Iratxe ; ; ; ; (Public Library Science, 2019-03-19)
Tench (Tinca tinca L.) has great economic potential due to its high rate of fecundity and long-life span. Population genetic studies based on allozymes, microsatellites, PCR-RFLP and sequence analysis of genes and DNA ... -
A Proteomic Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes
Ramírez Sánchez, Juan Manuel; Prieto Agujeta, Gorka ; ; ; ; Alduntzin Egizurain, Unai ; Osinalde Moraleja, Nerea ; ; Lectez, Benoît ; ; Rodríguez Pérez, José Antonio ; ; ; ; ; Arizmendi Bastarrika, Jesús María ; Mayor Martínez, Ugo (MDPI, 2021-05-03)
The human genome contains nearly 100 deubiquitinating enzymes (DUBs) responsible for removing ubiquitin moieties from a large variety of substrates. Which DUBs are responsible for targeting which substrates remain mostly ... -
A Recording Form for Differential Diagnosis of Arthropathies
García Ventades, Nerea; Martín Laza, Imanol ; Hervella Afonso, Montserrat ; De la Rúa Vaca, Concepción (Elsevier, 2018-03)
The present study is focused on a group of arthropathies that may have very similar bone manifestations (rheumatoid arthritis, ankylosing spondylitis, reactive arthritis, psoriatic arthritis, osteoarthritis and diffuse ... -
A short exposure to a semi-natural habitat alleviates the honey bee hive microbial imbalance caused by agricultural stress
; ; ; ; ; ; ; ; ; Zarraonaindia Martínez, Iratxe (Nature, 2022-11)
Honeybee health and the species' gut microbiota are interconnected. Also noteworthy are the multiple niches present within hives, each with distinct microbiotas and all coexisting, which we termed "apibiome". External ... -
A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis
Sarasola, Esther; Rodríguez Pérez, José Antonio; Garrote Llanos, María Isabel; Arístegui Fernández, Javier; García-Barcina, María J. (BioMed Central, 2011-06-27)
Background: Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive genetic disease characterized by the lack of reaction to noxious stimuli and anhidrosis. It is caused by mutations in the ... -
A Systematic Two-Sample Mendelian Randomization Analysis Identifies Shared Genetic Origin of Endometriosis and Associated Phenotypes
Garitazelaia González, Aiara; Rueda Martínez, Aintzane; Arauzo, Rebeca; De Miguel, Jokin; Cilleros Portet, Ariadna; Marí Alemany, Sergi; Bilbao Catalá, José Ramón ; Fernández Jiménez, Nora ; García Santisteban, Iraia (MDPI, 2021-01-03)
Endometriosis, one of the most common gynecological disorders, is a complex disease characterized by the growth of endometrial-like tissue in extra-uterine locations and is a cause of pelvic pain and infertility. Evidence ... -
A Two-Sample Mendelian Randomization Analysis Investigates Associations Between Gut Microbiota and Celiac Disease
García Santisteban, Iraia; Cilleros Portet, Ariadna ; Moyua Ormazabal, Elisabet; Kurilshikov, Alexander; Zhernakova, Alexandra; García Etxebarria, Koldo; Fernández Jiménez, Nora ; Bilbao Catalá, José Ramón (MDPI, 2020-05-14)
Celiac disease (CeD) is a complex immune-mediated inflammatory condition triggered by the ingestion of gluten in genetically predisposed individuals. Literature suggests that alterations in gut microbiota composition and ... -
A Universal Antigen-Ranking Method to Design Personalized Vaccines Targeting Neoantigens against Melanoma
Malaina Celada, Iker; Martínez Fernández, Luis ; ; Alonso Alegre, Santos ; Boyano López, María Dolores ; Asumendi Mallea, Aintzane ; ; ; ; (MDPI, 2023-01-05)
Background: The main purpose of this article is to introduce a universal mathematics-aided vaccine design method against malignant melanoma based on neoantigens. The universal method can be adapted to the mutanome of each ... -
Accuracy in Copy Number Calling by qPCR and PRT : A Matter of DNA
; ; ; ; Irastorza Terradillos, Iñaki Xarles; Castaño González, Luis Antonio ; ; Bilbao Catalá, José Ramón (Public Library of Science, 2011-12-13)
The possible implication of copy number variation (CNV) in the genetic susceptibility to human disease needs to be assessed using robust methods that can be applied at a population scale. In this report, we analyze the ... -
Aldaera ez-kodetzaileak eta epitranskriptomika: eritasun zeliakoarekin asoziatutako eremu baten azterketa funtzionala
(2022-03-11)Eritasun Zeliakoa (EZ) genetikoki sentikorrak diren pertsonetan garatzen den gaixotasun autoimmunekonplexua da. Glutenak erantzun immunea eragiten die eta gaur egun dagoen tratamendu bakarra biziosorako glutenik gabeko ... -
An E2F7-Dependent Transcriptional Program Modulates DNA Damage Repair And Genomic Stability
; Apraiz García, Aintzane; Vallejo Rodríguez, Jon ; García Santisteban, Iraia ; Fullaondo Elordui-Zapaterieche, Asier ; ; ; Zubiaga Elordieta, Ana María (Oxford University Press, 2018-05-18)
The cellular response to DNA damage is essential for maintaining the integrity of the genome. Recent evidence has identified E2F7 as a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes. ... -
Analysis of the essentiality of phosphatidylserine decarboxylase in endocrine resistant breast cancer cells
(2022-10-27)Uno de los mayores problemas en la clínica a la hora de tratar el cáncer de mama es el desarrollo de resistencia a las terapias endocrinas, debido a su alta frecuencia y mayor agresividad. Se ha demostrado que las células ... -
Análisis funcional y de reconstitución traduccional de mutaciones hereditarias del gen PTEN en pacientes con síndromes tumorales y de autismo
Luna-Blanco, Sandra (2022-05-23)
El gen PTEN es uno de los supresores tumorales más importantes junto a p53. PTEN antagoniza directamente la ruta de señalización oncogénica de la fosfatidilinositol 3-quinasa (PI3K), ruta involucrada en procesos celulares ...