BackExaminar por departamento (eus.) "Kimika organikoa I"
Now showing items 1-20 of 224
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1, 2, 3 - Triazoles as key frameworks in drug discovery & metal catalysis
Irastorza Epelde, Aitziber
(2017-07-07)
La tesis se enmarca dentro de la química de los 1H-1,2,3-triazoles y sus sales de N-alquil-triazolio. El trabajo realizado contempla los siguientes objetivos:1.- Sintetizar y estudiar los 1H-1,2,3-triazoles como plantillas ... -
1H-Imidazol-4(5H)-ones and thiazol-4(5H)-ones as emerging pronucleophiles in asymmetric catalysis
Mielgo Vicente, María Antonia; (Beilstein Institut, 2016-05-09)
Asymmetric catalysis represents a very powerful tool for the synthesis of enantiopure compounds. In this context the main focus has been directed not only to the search for new efficient chiral catalysts, but also to the ... -
5-Ethoxy-1-(4-methoxyphenyl)-5-methyl-3-phenylimidazolidine-2,4-dione
; ; Martínez de Marigorta Izaga, Edorta; Palacios Gambra, Francisco Javier ; Vicario Hernando, Javier (MDPI, 2021-05-28)
The title compound is a hydantoin derivative that has been synthesized through a three-component reaction of ethyl pyruvate, p-anisidine and phenyl isocyanate. This paper provides a comprehensive spectral dataset for the ... -
A Brønsted Acid-Catalyzed Multicomponent Reaction for the Synthesis of Highly Functionalized γ-Lactam Derivatives
; Martínez de Marigorta Izaga, Edorta; Palacios Gambra, Francisco Javier ; Vicario Hernando, Javier (MDPI, 2019-08)
Bronsted acids catalyze a multicomponent reaction of benzaldehyde with amines and diethyl acetylenedicarboxylate to afford highly functionalized gamma-lactam derivatives. The reaction consists of a Mannich reaction of an ... -
A Call for a Change in Policy Regarding the Necessity for SDE Tests to Validate the Veracity of the Outcome of Enantioselective Syntheses, the Inherent Chiral State of Natural Products, and Other Cases Involving Enantioenriched Samples
Han, Jianlin; Dembinski, Roman; Soloshonok, Vadym Anatolievch ; Klika, Karel D. (MDPI, 2021-06-30)
We wish to draw attention to an important issue concerning scientific practice with regard to enhancing the quality of publications in <i>Molecules</i> (as well as for other journals) [...] -
A computational glance at organometallic cyclizations and coupling reactions
(2016-07-18)Organometallic chemistry is one of the main research topics in chemical science.Nowadays, organometallic reactions are the subject of intensive theoretical investigations.However, in many cases, only joint experimental and ... -
A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors
; ; ; ; Palacios Gambra, Francisco Javier; Alonso Pérez, Concepción Estibaliz ; ; (MDPI, 2021-07-15)
DNA sensors can be used as robust tools for high-throughput drug screening of small molecules with the potential to inhibit specific enzymes. As enzymes work in complex biological pathways, it is important to screen for ... -
A Multicomponent Protocol for the Synthesis of Highly Functionalized γ-Lactam Derivatives and Their Applications as Antiproliferative Agents
; ; ; ; ; Martínez de Marigorta Izaga, Edorta; Pedraz Muñoz, José Luis ; Palacios Gambra, Francisco Javier ; Vicario Hernando, Javier (MDPI, 2021-08-09)
An efficient synthetic methodology for the preparation of 3-amino 1,5-dihydro-2H-pyrrol-2-ones through a multicomponent reaction of amines, aldehydes, and pyruvate derivatives is reported. In addition, the densely substituted ... -
A Pd-Catalysed [4 + 2] Annulation Strategy to Densely Functionalised N-Heterocycles
(2021-03-25)[EN]This thesis describes the synthesis of a library of novel sp3-rich N-heterocycles containing orthogonal functionality via a palladium-catalysed allylation-condensation sequence. The employment of a readily available ... -
Accessing Chiral Pyrrolodiketopiperazines under Organocatalytic Conditions
(American Chemical Society, 2022-12)The production of chiral pyrrolodiketopiperazines under organocatalytic conditions demonstrates the capacity of bicyclic acylpyrrol lactims to perform as pronucleophiles in direct carbon–carbon bond forming reactions. The ... -
Additive and Emergent Catalytic Properties of Dimeric Unnatural Amino Acid Derivatives: Aldol and Conjugate Additions.
; ; ; ; ; Cossío Mora, Fernando Pedro (Wiley, 2021-11-11)
[EN]Different densely substituted L- and D-proline esters were prepared by asymmetric (3+2) cycloaddition reactions catalyzed by conveniently selected EhuPhos chiral ligands. The gamma-nitro-2-alkoxycarbonyl pyrrolidines ... -
Adición conjugada asimétrica de equivalentes umpolung de acilo y carboxilo : auxiliares quirales vs organocatálisis
(2012-07-04)En el trabajo de investigación que se recoge en la presente memoria se ha estudiado la adición conjugada asimétrica de equivalentes sintéticos de aniones acilo y carboxilo. Para dicho fin, han sido dos las estrategias ... -
Advances in the Development of Trifluoromethoxylation Reagents
Wang, Qian; Zhang, Xin; Sorochinsky, Alexander E.; Butler, Greg; Han, Jianlin; Soloshonok, Vadym Anatolievch (MDPI, 2021-12-10)
This review provides a short summary of the traditional methods for synthesis of CF3-O-containing compounds, followed by a critical overview of known trifluoromethoxylating reagents, focusing on their preparation, synthetic ... -
Aldehídos en reacciones de Michael enantioselectivas catalizadas por derivados del prolinol
(2012-04-10)El trabajo que se recoge en la presente memoria está enmarcado en el área de la organocatálisis asimétrica. Más concretamente, se describe la funcionalización de aldehídos en posiciones ¿ y ß mediante reacciones de ... -
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Alfa-keto amides in bronsted-base mediated stereoselective aldol-and mannich-reactions: access to chiral polyfunctionalyzed scaffolds
(2017-07-11)La presente tesis ha tenido como objetivo principal la aplicación de métodos asimétricos organocatalíticos en transformaciones químicas fundamentales como la formación de enlaces carbono-carbono. Las dos líneas de trabajo ... -
Alkene selenenylation: A comprehensive analysis of relative reactivities, stereochemistry and asymmetric induction, and their comparisons with sulfenylation
Soloshonok, Vadym Anatolievch; Nelson, Donna J. (Beilstein Institut, 2011-06)
A broad perspective of various factors influencing alkene selenenylation has been developed by concurrent detailed analysis of key experimental and theoretical data, such as asymmetric induction, stereochemistry, relative ... -
alpha-Branched Ketone Dienolates: Base-Catalyzed Generation and Regio- and Enantioselective Addition Reactions
; ; ; ; ; Oyarbide Garmendia, Juan Miguel; (Wiley-VCH, 2019-05-14)
In this study, the unique capacity of bifunctional Brønsted bases to generate α-branched ketone dienolates and control both site- and stereoselectivity of their addition reactions to representative classes of carbon ... -
An Expedient Method for the Umpolung Coupling of Enols with Heteronucleophiles
; Carretero Cerdán, Alba; Sanz-Marco, Amparo ; ; (Wiley, 2022-08)
[EN] In this paper, we present an unprecedented and general umpolung protocol that allows the functionalization of silyl enol ethers and of 1,3-dicarbonyl compounds with a large range of heteroatom nucleophiles, including ... -
An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to C=O and C=N bonds
; Martínez de Marigorta Izaga, Edorta; Palacios Gambra, Francisco Javier ; Vicario Hernando, Javier ; (RSC, 2022-09-07)
Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first examples were reported 18 years ago by Akiyama and Terada. Although they were originally developed for enantioselective additions ...