BackExaminar por departamento (eus.) "Kimika organikoa II"
Now showing items 1-20 of 99
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A pre-targeting approach to boron neutron capture therapy: towards multipurpose boron-enriched therapeutic agents.
(2020-07-06)En la presente tesis se describe en primer lugar una comparativa entre diferentes técnicas analíticas para la caracterización de anticuerpos funcionalizados con ligandos utilizados típicamente en imagen nuclear. Se comparar ... -
Activación de aldehídos a,b-insaturados mediante aminocatálisis en procesos enantioselectivos. Cicloadiciones (3+2) y reacciones en cascada Michael/Henry
(2014-01-21)During the research that it is summarized in the present memory, the activation of enals via iminium ion catalysis in different transformations has been studied. Firstly, a 1,3-dipolar cycloaddition between stable azomethine ... -
Antibacterial and cytotoxic activities of new sphingolipids and other constituents isolated from Cissus incisa leaves
(Elsevier, 2020-08)Cissus incisa is used in traditional Mexican medicine to treat certain ailments, infectious or cancerous diseases. Excepting for our previous research, this species had no scientific reports validating its traditional use. ... -
Application of enzymes in Nitrogen-13 radiochemistry; biocatalytic synthesis of PET radionuclides with biomedical interest
(2017-09-18)La instalación generalizada de ciclotrones biomédicos a nivel mundial ha suscitado un gran interés entre la comunidad científica, que ve la tomografía por emisión de positrones (PET, del inglés Positron Emission Tomography) ... -
Asymmetric organocatalytic cascade reactions
(2014-03-12)[ES]En la presente memoria se recoge el trabajo de investigación enmarcado en elempleo de aminas secundarias quirales como organocatalizadores para el diseño dereacciones en cascada con el fin de obtener compuestos de ... -
Asymmetric transformations of donor-acceptor cyclopropanes under bronsted acid catalysis
(2019-10-10)Los ciclopropanos dadores-aceptores, son considerados importantes estructuras en la construcción de moleculas más complejas, debido a su tendencia termodinámica a sufrir apertura de anillo impulsada por la liberación de ... -
Asymmetric transformations under chiral bronsted acid catalysis: (4+3) cycloaddition and allylboration of imines
(2017-05-19)La memoria recoge el estudio y desarrollo de diversas reacciones organocatalíticas enantioselectivas. Explorando, en primer lugar, la utilización de alenamidas como precursores de cationes oxaalílicos en la cicloadición ... -
Carbopalladation/Suzuki Coupling Cascade for the Generation of Quaternary Centers. Access to Pyrrolo[1,2-b]isoquinolines
(American Chemical Society, 2019-07-29)A convergent route to pyrrolo[1,2-b]isoquinolines with a quaternary center at C-10 has been developed, that implies a sequential Pd(0)-catalyzed carbopalladation followed by cross-coupling reaction with boronic acids. ... -
Carboxylates as Nucleophiles in the Enantioselective Ring-Opening of Formylcyclopropanes under IminiumIon Catalysis
; ; Uria Pujana, Uxue
; Carrillo Fernández, María Luisa ; ; ; Vicario Hernando, José Luis (Wiley-VCH, 2018-04-12)
In this work, carboxylic acids, which are typically regarded as poor nucleophiles, are demonstrated to be competent reagents to promote the ring-opening of formylcyclopropanes after activation of the latter through iminium ... -
Catalytic Enantioselective Cloke–Wilson Rearrangement
; Manzano, Rubén; Uria Pujana, Uxue ; Carrillo Fernández, María Luisa ; ; ; ; Vicario Hernando, José Luis (Wiley-VCH, 2018-05-09)
Racemic cyclopropyl ketones undergo enantioselective rearrangement to deliver the corresponding dihydrofurans in the presence of a chiral phosphoric acid as the catalyst. The reaction involves activation of the donor-acceptor ... -
Catalytic enantioselective domino Michael/transannular aldol reaction under bifunctional catalysis
; ; Carrillo Fernández, María Luisa; Uria Pujana, Uxue ; Prieto Aretxabaleta, Liher ; Manzano, Rubén ; Vicario Hernando, José Luis (Royal Society of Chemistry, 2020-09-28)
The enantioselective Michael reaction catalyzed by a bifunctional tertiary amine/squaramide has been used to trigger a Michael/transannular aldol cascade process that leads to densely substituted bicyclo[5.4.0]undecanes ... -
Catalytic Enantioselective Transannular Morita–Baylis–Hillman Reaction
; Manzano, Rubén; ; Carrillo Fernández, María Luisa ; Uria Pujana, Uxue ; Vicario Hernando, José Luis (American Chemical Society, 2019)
Catalytic and enantioselective approaches to transannular reactions are very limited and mostly are based on chiral Lewis acid catalyzed pericyclic reactions. In this report, we present an efficient and straightforward ... -
Catalytic Generation of Donor-Acceptor Cyclopropanes under N-Heterocyclic Carbene Activation and their Stereoselective Reaction with Alkylideneoxindoles
Prieto Aretxabaleta, Liher; ; Uria Pujana, Uxue ; ; Carrillo Fernández, María Luisa ; Vicario Hernando, José Luis (Wiley-VCH, 2017-04-10)
Formylcyclopropanes undergo activation in the presence of an N-heterocyclic carbene catalyst generating a donor-acceptor cyclopropane intermediate with the ability to undergo ring-opening followed by formal [4+2] ... -
Characterization and Optimization of the Alkaline Hydrolysis of Polyacrylonitrile Membranes
; ; Moreno Benítez, María Isabel; Vilas Vilela, José Luis (MDPI, 2019-11-08)
There is currently an increasing interest in the development of polyacrylonitrile (PAN)-based membranes with new and enhanced properties which are of special importance in the processes of pervaporation, purification, and ... -
Chiral Bronsted Acid-Catalyzed Enantioselective alpha-Amidoalkylation Reactions: A Joint Experimental and Predictive Study,
(Wiley VCH, 2016-12)Enamides with a free NH group have been evaluated as nucleophiles in chiral Bronsted acid-catalyzed enantioselective alpha-amidoalkylation reactions of bicyclic hydroxylactams for the generation of quaternary stereocenters. ... -
Complex Networks and Machine Learning: From Molecular to Social Sciences
(MDPI, 2019-11)Combining complex networks analysis methods with machine learning (ML) algorithms have become a very useful strategy for the study of complex systems in applied sciences. Noteworthy, the structure and function of such ... -
Covalent organocatalysis for the development of new methodologies in asymmetric synthesis
(2017-05-03)En el presente trabajo se ha aplicado la organocatálisis a la activación de sustratos versátiles como lo son los cicloporpanos funcionalizados y las inonas, para el desarrollo de nuevas metodologías sintéticas. Así, se ha ... -
Cp*Co(III)-Catalyzed C−H Hydroarylation of Alkynes and Alkenes and Beyond: A Versatile Synthetic Tool
(ACS, 2020-09-15)The use of earth-abundant first-row transition metals, such as cobalt, in C−H activation reactions for the construction and functionalization of a wide variety of structures has become a central topic in synthetic ... -
Data Analysis in Chemistry and Bio-Medical Sciences
(MDPI, 2016-12-14)There is an increasing necessity for multidisciplinary collaborations in molecular science between experimentalists and theoretical scientists, as well as among theoretical scientists from different fields. One of the more ... -
Design and engineering of artificial metabolic cells for chemical manufacturing.
(2019-04-09)La biocatálisis industrial ha demostrado ser una alternativa más económica y limpia a la síntesis químicatradicional. Sin embargo, la baja estabilidad de las enzimas, el insuficiente reciclaje de moléculas y laslimitaciones ...