BackExaminar por departamento (eus.) "Kimika organikoa II"
Now showing items 1-20 of 72
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A pre-targeting approach to boron neutron capture therapy: towards multipurpose boron-enriched therapeutic agents.
(2020-07-06)En la presente tesis se describe en primer lugar una comparativa entre diferentes técnicas analíticas para la caracterización de anticuerpos funcionalizados con ligandos utilizados típicamente en imagen nuclear. Se comparar ... -
Activación de aldehídos a,b-insaturados mediante aminocatálisis en procesos enantioselectivos. Cicloadiciones (3+2) y reacciones en cascada Michael/Henry
(2014-01-21)During the research that it is summarized in the present memory, the activation of enals via iminium ion catalysis in different transformations has been studied. Firstly, a 1,3-dipolar cycloaddition between stable azomethine ... -
Antibacterial and cytotoxic activities of new sphingolipids and other constituents isolated from Cissus incisa leaves
(Elsevier, 2020-08)Cissus incisa is used in traditional Mexican medicine to treat certain ailments, infectious or cancerous diseases. Excepting for our previous research, this species had no scientific reports validating its traditional use. ... -
Application of enzymes in Nitrogen-13 radiochemistry; biocatalytic synthesis of PET radionuclides with biomedical interest
(2017-09-18)La instalación generalizada de ciclotrones biomédicos a nivel mundial ha suscitado un gran interés entre la comunidad científica, que ve la tomografía por emisión de positrones (PET, del inglés Positron Emission Tomography) ... -
Asymmetric organocatalytic cascade reactions
(2014-03-12)[ES]En la presente memoria se recoge el trabajo de investigación enmarcado en elempleo de aminas secundarias quirales como organocatalizadores para el diseño dereacciones en cascada con el fin de obtener compuestos de ... -
Asymmetric transformations of donor-acceptor cyclopropanes under bronsted acid catalysis
(2019-10-10)Los ciclopropanos dadores-aceptores, son considerados importantes estructuras en la construcción de moleculas más complejas, debido a su tendencia termodinámica a sufrir apertura de anillo impulsada por la liberación de ... -
Asymmetric transformations under chiral bronsted acid catalysis: (4+3) cycloaddition and allylboration of imines
(2017-05-19)La memoria recoge el estudio y desarrollo de diversas reacciones organocatalíticas enantioselectivas. Explorando, en primer lugar, la utilización de alenamidas como precursores de cationes oxaalílicos en la cicloadición ... -
Characterization and Optimization of the Alkaline Hydrolysis of Polyacrylonitrile Membranes
Pérez Álvarez, Leyre
; Ruiz Rubio, Leire ; Moreno Benítez, María Isabel ; Vilas Vilela, José Luis (MDPI, 2019-11-08)
There is currently an increasing interest in the development of polyacrylonitrile (PAN)-based membranes with new and enhanced properties which are of special importance in the processes of pervaporation, purification, and ... -
Chiral Bronsted Acid-Catalyzed Enantioselective alpha-Amidoalkylation Reactions: A Joint Experimental and Predictive Study,
; ; Sotomayor Anduiza, María Nuria; González Díaz, Humberto ; (Wiley VCH, 2016-12)
Enamides with a free NH group have been evaluated as nucleophiles in chiral Bronsted acid-catalyzed enantioselective alpha-amidoalkylation reactions of bicyclic hydroxylactams for the generation of quaternary stereocenters. ... -
Complex Networks and Machine Learning: From Molecular to Social Sciences
Quesada, David; Cruz Monteagudo, Maykel; Fletcher, Terace; Duardo Sánchez, Aliuska; González Díaz, Humberto (MDPI, 2019-11)
Combining complex networks analysis methods with machine learning (ML) algorithms have become a very useful strategy for the study of complex systems in applied sciences. Noteworthy, the structure and function of such ... -
Covalent organocatalysis for the development of new methodologies in asymmetric synthesis
(2017-05-03)En el presente trabajo se ha aplicado la organocatálisis a la activación de sustratos versátiles como lo son los cicloporpanos funcionalizados y las inonas, para el desarrollo de nuevas metodologías sintéticas. Así, se ha ... -
Data Analysis in Chemistry and Bio-Medical Sciences
Todeschini, Roberto; Pazos, Alejandro; Arrasate Gil, Sonia; González Díaz, Humberto (MDPI, 2016-12-14)
There is an increasing necessity for multidisciplinary collaborations in molecular science between experimentalists and theoretical scientists, as well as among theoretical scientists from different fields. One of the more ... -
Design and engineering of artificial metabolic cells for chemical manufacturing.
(2019-04-09)La biocatálisis industrial ha demostrado ser una alternativa más económica y limpia a la síntesis químicatradicional. Sin embargo, la baja estabilidad de las enzimas, el insuficiente reciclaje de moléculas y laslimitaciones ... -
Exploring new labelling strategies for boronated compounds: towards fast development and efficient assessment of BNCT drug candidates
(2015-10-28)La terapia por captura de neutrones (BNCT o Boron Neutron Capture Therapy), fue descrita por primera vez por Locher en 1936 y es una modalidad terapéutica binaria para el tratamiento del cáncer que se basa en la captura ... -
Fluorinated carbohydrates as chemical probes formolecular recognition studies. Current statusand perspectives
Linclau, Bruno; Ardá, Ana; Reichardt, Niels Christian; Sollogoub, Matthieu; Unione, Luca; Vincent, Stéphane P.; Jiménez Barbero, Jesús (Royal Society of Chemistry, 2020-06-21)
This review provides an extensive summary of the effects of carbohydrate fluorination with regard to changes in physical, chemical and biological properties with respect to regular saccharides. The specific structural, ... -
Fluorinated Carbohydrates as Lectin Ligands: Simultaneous Screening of a Monosaccharide Library and Chemical Mapping by F-19 NMR Spectroscopy
Martínez, José Daniel; Manzano, Ana I.; Calviño, Eva; De Diego, Ana; Rodríguez de Francisco, Borja; Romanó, Cecilia; Oscarson, Stefan; Millet Aguilar-Galindo, Oscar; Gabius, Hans Joachim; Jiménez Barbero, Jesús; Cañada Vicinay, Francisco Javier (American Chemical Society, 2020-12-18)
Molecular recognition of carbohydrates is a key step in essential biological processes. Carbohydrate receptors can distinguish monosaccharides even if they only differ in a single aspect of the orientation of the hydroxyl ... -
Fluorine Labeling of Nanoparticles and In Vivo 19F Magnetic Resonance Imaging
Arango Rodríguez, Juan Manuel; Padró, Daniel; Blanco, Jorge; López Fernández, Sonia; Castellnou Arenas, Pilar; Villa Valverde, Palmira; Ruiz Cabello, Jesús; Martín Muñoz, Abraham; Carril García, Mónica (American Chemical Society, 2021-03-24)
Fluorinated nanoparticles have increasing applications, but they are still challenging to prepare, especially in the case of water-soluble fluorinated nanoparticles. Herein, a fluorine labeling strategy is presented that ... -
Galectin-4 N-Terminal Domain: Binding Preferences Toward A and B Antigens with Different Peripheral Core Presentations
Quintana García, Jon Imanol; Delgado, Sandra; Núñez Franco, Reyes; Cañada Vicinay, Francisco Javier; Jiménez Oses, Gonzalo; Jiménez Barbero, Jesús; Ardá, Ana (Frontiers Media, 2021-04-21)
The tandem-repeat Galectin-4 (Gal-4) contains two different domains covalently linked through a short flexible peptide. Both domains have been shown to bind preferentially to A and B histo blood group antigens with different ... -
Gene Prioritization, Communality Analysis, Networking and Metabolic Integrated Pathway to Better Understand Breast Cancer Pathogenesis
López Cortés, Andrés; Paz y Miño, César; Cabrera Andrade, Alejandro; Barigye, Stephen J.; Munteanu, Cristian R.; González Díaz, Humberto; Pazos, Alejandro; Pérez Castillo, Yunierkis; Tejera, Eduardo (Nature Publishing Group, 2018-11-12)
Consensus strategy was proved to be highly efficient in the recognition of gene-disease association. Therefore, the main objective of this study was to apply theoretical approaches to explore genes and communities directly ... -
Glycan structures and their interactions with proteins. A NMR view
Gimeno, Ana; Valverde, Pablo; Ardá, Ana; Jiménez Barbero, Jesús (Elsevier, 2019-12)
Carbohydrate molecules are essential actors in key biological events, being involved as recognition points for cell-cell and cell-matrix interactions related to health and disease. Despite outstanding advances in cryoEM, ...