BackBrowsing by Author "Fernández Ramos, David"
Now showing items 1-13 of 13
-
A Morphological Method for Ammonia Detection in Liver
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Martínez Chantar, María Luz
(Public Library Science, 2017-03-20)
Hyperammonemia is a metabolic condition characterized by elevated levels of ammonia and a common event in acute liver injury/ failure and chronic liver disease. Even though hepatic ammonia levels are potential predictive ... -
Anti-miR-518d-5p Overcomes Liver Tumor Cell Death Resistance Through Mitochondrial Activity
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Bañales Asurmendi, Jesús María; ; ; ; ; ; ; Martínez Chantar, María Luz (Springer Nature, 2021-05-28)
Dysregulation of miRNAs is a hallmark of cancer, modulating oncogenes, tumor suppressors, and drug responsiveness. The multi-kinase inhibitor sorafenib is one of the first-line drugs for advanced hepatocellular carcinoma ... -
Arachidyl Amido Cholanoic Acid Improves Liver Glucose and Lipid Homeostasis in Nonalcoholic Steatohepatitis Via AMPK and mTOR Regulation
Fernández Ramos, David; Lopitz Otsoa, Fernando; De la Cruz Villar, Laura; Bilbao García, Jon; Pagano, Martina; Mosca, Laura; Bizkarguenaga, Maider; ; ; Iruarrizaga Lejarreta, Marta; Sot, Jesús; Tsvirkun, Darya; Van Liempd, Sebastiaan Martijn; Goñi Urcelay, Félix María; Alonso, Cristina; Martínez Chantar, María Luz ; ; Hayardeny, Liat; Lu, Shelly C.; Mato, José M. (Baishideng, 2020-09-14)
BACKGROUND Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. ... -
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Izeta Permisán, Ander; ; ; ; ; ; ; Martínez Chantar, María Luz ; ; ; ; ; ; ; ; Carracedo Pérez, Arkaitz ; ; (The American Society for Clinical Investigation, 2020-07-01)
Cancer cells can develop a strong addiction to discrete molecular regulators, which control the aberrant gene expression programs that drive and maintain the cancer phenotype. Here, we report the identification of the ... -
Magnesium Accumulation Upon Cyclin M4 Silencing Activates Microsomal Triglyceride Transfer Protein Improving NASH
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-07)
Background & Aims: Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg2+ across cell membranes. Herein, ... -
Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Martínez de Marigorta Izaga, Edorta; ; ; ; ; ; ; ; ; ; Bañales Asurmendi, Jesús María ; ; ; ; ; ; ; ; ; ; (Wiley, 2022-10)
Background and Aims We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we align metabolomic signatures with cardiovascular disease (CVD) and genetic risk factors. Approach and ... -
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease
Fernández Tussy, Pablo; Fernández Ramos, David; Lopitz Otsoa, Fernando; Simon, Jorge; Barbier Torres, Lucía; Gómez Santos, Beatriz; Nuñez García, Maitane; ; ; Gutiérrez de Juan, Virginia; ; Rodríguez Agudo, Rubén; Iruzubieta, Paula; Anguita Castillo, Juan de Dios; Castro, Rui E.; Champagne, Devin; Rincon, Mercedes; ; Arslanow, Anita; Krawczyk, Marcin; Lammert, Frank; Kirchmeyer, Melanie; Behrmann, Iris; Crespo, Javier; Lu, Shelly C.; Mato, José M.; Varela Rey, Marta; ; Delgado, Teresa C.; Martínez Chantar, María Luz (Elsevier, 2019-08-16)
Objective: Non-alcoholic fatly liver disease (NAFLD) is a complex pathology in which several dysfunctions, including alterations in metabolic pathways, mitochondrial functionality and unbalanced lipid import/export, lead ... -
Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Abecia Aliende, Leticia; ; ; Abrescia, Nicola G. A. ; ; ; ; ; ; ; ; ; ; ; Martínez Chantar, María Luz (Wiley, 2022-03)
[EN] Background and Aims Hepatic ischemia-reperfusion injury (IRI) is the leading cause of early posttransplantation organ failure as mitochondrial respiration and ATP production are affected. A shortage of donors has ... -
Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis
; ; ; ; ; ; ; ; ; ; ; ; Arizmendi Bastarrika, Jesús María; ; ; ; Ávila, Matías A. ; Bañales Asurmendi, Jesús María ; ; ; ; ; ; ; Mayor Martínez, Ugo ; Martínez Chantar, María Luz ; (MDPI, 2020-11-27)
Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological ... -
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis
; ; ; ; ; ; ; ; ; ; ; ; ; Buqué García, Xabier; ; ; ; ; ; Bañales Asurmendi, Jesús María ; Ávila, Matías A. ; ; ; ; ; Mayor Martínez, Ugo ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2021-06-18)
[EN] Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic ... -
New Oncogenic Drivers in Hepatocellular Carcinoma: Role of the RNA Binding Protein Hu antigen R
(2014-01-22)[ES]La enfermedad hepática crónica es una de las principales causas de mortalidad en humanos.Comprende enfermedades con diferentes etiologías como la infección por los virus de la hepatitis B y C,toxinas, consumo de alcohol ... -
Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
Barbier Torres, Lucía; Fortner, Karen A.; Iruzubieta, Paula; Delgado, Teresa C.; Giddings, Emily; Chen, Youdinghuan; Champagne, Devin; Fernández Ramos, David; Mestre, Daniela; Gómez Santos, Beatriz; Varela Rey, Marta; Gutiérrez de Juan, Virginia; Fernández Tussy, Pablo; Zubiete Franco, Imanol; García Monzón, Carmelo; González Rodríguez, Águeda; Oza, Dhaval; Valença Pereira, Felipe; Fang, Qian; Crespo, Javier; ; Tremblay, Frederic; Christensen, Brock C.; Anguita Castillo, Juan de Dios; Martínez Chantar, María Luz; Rincón, Mercedes (Nature, 2020-07-03)
Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with an estimated 25% worldwide prevalence. No drugs have yet been approved and NAFLD remains a major unmet need. Here, we identify MCJ ... -
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Ávila, Matías A.; ; ; ; ; ; Martínez Chantar, María Luz (Elsevier, 2019-02)
BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular ...