Browsing by Author "Nunes Xavier, Caroline E."
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Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation
Nunes Xavier, Caroline E.; Zaldumbide Dueñas, Laura; Aurtenetxe, Olaia; López Almaraz, Ricardo; López Fernández de Villaverde, José Ignacio ; Pulido Murillo, Rafael (MDPI, 2019-03-01)Dual-specificity phosphatases (DUSPs) are important regulators of neuronal cell growth and differentiation by targeting proteins essential to neuronal survival in signaling pathways, among which the MAP kinases (MAPKs) ... -
Identification and Functional Analysis of a Novel CTNNB1 Mutation in Pediatric Medulloblastoma
Alaña, Lide; Nunes Xavier, Caroline E.; Zaldumbide Dueñas, Laura; Martín Guerrero, Idoia; Mosteiro González, Lorena; Alba Pavón, Piedad; Villate, Olatz; García Obregón, Susana; González García, Hermenegildo; Herraiz, Raquel; Astigarraga Aguirre, María Iciar; Pulido Murillo, Rafael; García Ariza, Miguel Angel (MDPI, 2022-01-14)Medulloblastoma is the primary malignant tumor of the Central Nervous System (CNS) most common in pediatrics. We present here, the histological, molecular, and functional analysis of a cohort of 88 pediatric medulloblastoma ... -
MMADHC Premature Termination Codons in the Pathogenesis of Cobalamin D Disorder: Potential of Translational Readthrough Reconstitution
Torices, Leire; De las Heras Montero, Javier Adolfo; Arango Lasprilla, Juan Carlos; Cortés Díaz, Jesús María; Nunes Xavier, Caroline E.; Pulido Murillo, Rafael (Elsevier, 2021-03)Mutations in the MMADHC gene cause cobalamin D disorder (cblD), an autosomal recessive inborn disease with defects in intracellular cobalamin (cbl, vitamin B12) metabolism. CblD patients present methylmalonic aciduria ... -
Predicting Survival of Metastatic Clear Cell Renal Cell Cancer Treated with VEGFR-TKI-Based Sequential Therapy
Angulo, Javier C.; Larrinaga Embeita, Gorka ; Lecumberri, David; Iturregui, Ane Miren; Solano Iturri, Jon Danel; Lawrie, Charles H.; Armesto, María; Dorado, Juan F.; Nunes Xavier, Caroline E.; Pulido, Rafael; Manini, Claudia; López, José I. (MDPI, 2024-08-07)(1) Objective: To develop a clinically useful nomogram that may provide a more individualized and accurate estimation of cancer-specific survival (CSS) for patients with clear-cell (CC) metastatic renal cell carcinoma ... -
(Pro)renin Receptor Is a Novel Independent Prognostic Marker in Invasive Urothelial Carcinoma of the Bladder
Larrinaga Embeita, Gorka ; Calvete Candenas, Julio; Solano Iturri, Jon Danel; Martín, Ana M.; Pueyo, Angel; Nunes Xavier, Caroline E.; Pulido Murillo, Rafael; Dorado, Juan F.; López Fernández de Villaverde, José Ignacio ; Angulo, Javier C. (MDPI, 2021-11-11)(Pro)renin receptor (PRR) is being investigated in several malignancies as it activates pathogenic pathways that contribute to cell proliferation, immunosuppressive microenvironments, and acquisition of aggressive neoplastic ... -
Protein tyrosine phosphatase modulates cell growth and associates with poor outcome in human neuroblastoma
Nunes Xavier, Caroline E.; Aurtenetxe, Olaia; Zaldumbide Dueñas, Laura; López Almaraz, Ricardo; Erramuzpe Aliaga, Asier; Cortés Díaz, Jesús María; López Fernández de Villaverde, José Ignacio ; Pulido Murillo, Rafael (BMC, 2019-12-14)Background Protein tyrosine phosphatases (PTPs) regulate neuronal differentiation and survival, but their expression patterns and functions in human neuroblastoma (NB) are scarcely known. Here, we have investigated the ... -
The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases
Errarte Yarza, Peio; Guarch, Rosa; Pulido Murillo, Rafael; Blanco Criado, Lorena; Nunes Xavier, Caroline E.; Beitia San Vicente, Maider; Gil Goicouría, Francisco Javier ; Angulo, Javier C.; López Fernández de Villaverde, José Ignacio (Public Library Science, 2016-12-29)Clear cell renal cell carcinoma (CCRCC) is a heterogeneous and complex disease that frequently develops distant metastases. Fibroblast activation protein (FAP) is a serine peptidase the expression of which in cancer-associated ... -
The expression pattern of pyruvate dehydrogenase kinases predicts prognosis and correlates with immune exhaustion in clear cell renal cell carcinoma
Nunes Xavier, Caroline E.; Emaldi, Maite; Mingo Gómez de Oteo, Janire; Øyjord, Tove; Mælandsmo, Gunhild M.; Fodstad, Øystein; Errarte Yarza, Peio; Larrinaga Embeita, Gorka ; Llarena Ibarguren, Roberto; López, José I.; Pulido Murillo, Rafael (Nature, 2023-05)Renal cancer cells constitute a paradigm of tumor cells with a glycolytic reprogramming which drives metabolic alterations favouring cell survival and transformation. We studied the expression and activity of pyruvate ...