Now showing items 1-8 of 8

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      A beta oligomers promote oligodendrocyte differentiation and maturation via integrin beta 1 and Fyn kinase signaling 

      Quintela López, Tania; Ortiz Sanz, Carolina; Serrano Regal, María Paz; Gaminde Blasco, Adhara Mikaela; Valero Gómez-Lobo, Jorge; Baleriola, Jimena; Sánchez Gómez, María Victoria; Matute Almau, Carlos José; Alberdi Alfonso, Elena María (Nature Publishing Group, 2019-06-06)
      Alzheimer's disease (AD) is characterized by a progressive cognitive decline that correlates with the levels of amyloid beta-peptide (A beta) oligomers. Strong evidences connect changes of oligodendrocyte function with the ...
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      Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine 

      Moreno, Beatriz; Lopez, Iciar; Fernández-Díez, Begoña; Gottlieb, Miroslav; Matute Almau, Carlos José; Sánchez Gómez, María Victoria; Domercq García, María; Giralt, Albert; Alberch, Jordi; Collon, Kevin W.; Zhang, Helen; Parent, Jack M.; Teixido, Meritxell; Giralt, Ernest; Ceña, Valentín; Posadas, Inmaculada; Martínez-Pinilla, Eva; Villoslada, Pablo; Franco, Rafael (Public Library Science, 2014-03-05)
      Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ...
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      Expression and Function of GABA Receptors in Myelinating Cells 

      Serrano Regal, María Paz; Bayón Cordero, Laura; Ordaz, Rainald Pablo; Garay, Edith; Limon, Agenor; Arellano, Rogelio O.; Matute Almau, Carlos José; Sánchez Gómez, María Victoria (Frontiers Media, 2020-08-21)
      Myelin facilitates the fast transmission of nerve impulses and provides metabolic support to axons. Differentiation of oligodendrocyte progenitor cells (OPCs) and Schwann cell (SC) precursors is critical for myelination ...
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      Interacción entre quinasas y moléculas apoptóticas en la muerte oligodendroglial excitotóxica 

      Canedo Antelo, Manuel (2016-05-27)
      El fenómeno de excitotoxicidad glutamatérgica supone una de las causas subyacentes de multitud de enfermedades neurodegenerativas y afecta, entre otros tipos celulares, a los oligodendrocitos. Precisamente la vulnerabilidad ...
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      Pio del Rio Hortega and the discovery of the oligodendrocytes 

      Pérez Cerdá, Fernando; Sánchez Gómez, María Victoria; Matute Almau, Carlos José (Frontiers Research Foundation, 2015-07-07)
      Rio del Rio Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramon y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolas ...
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      Relevancia del receptor GABAB en el proceso de mielinización durante el desarrollo en rata 

      Luengas Escuza, Irene (2020-12-15)
      [ES] En enfermedades desmielinizantes como la esclerosis múltiple los oligodendrocitos, responsables de la mielinización en el sistema nervioso central, y las vainas de mielina que rodean los axones resultan dañados, ...
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      Role of GABAergic signaling in oligodendroglial differentiation, myelination and remyelination after demyelinating lesions. 

      Serrano Regal, María Paz (2019-11-12)
      Esta tesis doctoral ha consistido en el estudio de la implicación de la señalización GABAérgica en el proceso de diferenciación de las células oligodendrogliales, así como en la mielinización y en la remielinización que ...
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      The Link of Inflammation and Neurodegeneration in Progressive Multiple Sclerosis 

      Pérez Cerdá, Fernando; Sánchez Gómez, María Victoria; Matute Almau, Carlos José (Biomed Central, 2016-05-24)
      Progressive multiple sclerosis (MS) is characterized clinically by the accumulation of neurological disability without unequivocal recovery. Understanding the mechanisms that determine entering in this stage of the disease ...