Browsing by Author "Sabourin, Jean Charles"
Now showing items 1-4 of 4
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Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS
Noristani, Harun Najib; Sabourin, Jean Charles; Gerber, Yannick Nicolas; Teigell, Marisa; Sommacal, Andreas; Vivanco Ruiz, María del Mar; Weber, Markus; Perrin, Florence (Biomed Central, 2015-08-01)Background: There is growing evidence that microglia are key players in the pathological process of amyotrophic lateral sclerosis (ALS). It is suggested that microglia have a dual role in motoneurone degeneration through ... -
Early Functional Deficit and Microglial Disturbances in a Mouse Model of Amyotrophic Lateral Sclerosis
Gerber, Yannick Nicolas; Sabourin, Jean Charles; Rabano, Miriam; Vivanco Ruiz, María del Mar; Perrin, Florence (Public Library of Science, 2012-04-25)Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by selective motoneurons degeneration. There is today no clear-cut pathogenesis sequence nor any treatment. However growing ... -
Spinal cord injury induces astroglial conversion towards neuronal lineage
Noristani, Harun Najib; Sabourin, Jean Charles; Boukhaddaoui, Hassan; Chan-Seng, Emilie; Gerber, Yannick Nicolas; Perrin, Florence Evelyne (Biomed Central, 2016-10-06)Background: Neurons have intrinsic capability to regenerate after lesion, though not spontaneously. Spinal cord injury (SCI) causes permanent neurological impairments partly due to formation of a glial scar that is composed ... -
Unlike Physical Exercise, Modified Environment Increases the Lifespan of SOD1(G93A) Mice However Both Conditions Induce Cellular Changes
Gerber, Yannick Nicolas; Sabourin, Jean Charles; Hugnot, Jean-Philippe; Perrin, Florence (Public Library of Science, 2012-09-20)Background: Amyotrophic lateral sclerosis (ALS) is characterized by a gradual muscular paralysis resulting from progressive motoneurons death. ALS etiology remains unknown although it has been demonstrated to be a ...