Browsing by Author "Trueba Conde, Miguel Ángel"
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Bases estructurales del transporte de Mg2+ mediado por los factores homeostáticos CNNM2 y CNNM4, y de su interacción oncogénica con las fosfatasas PRL.
Giménez Mascarell, PaulaEl Magnesio, segundo catión intracelular más abundante, es un ión imprescindible en diversas funciones vitales como la neurotransmisión, la conductancia cardiaca o la síntesis de ATP. Este papel biológico trascendental ... -
Ceramide 1-phosphate (C1P) induces macrophage chemoattractant protein-1 release: involvement in C1P-stimulated cell migration.
Arana Urbieta, Lide; Ordóñez Zaragoza, Marta; Ouro Villasante, Alberto; Rivera, Io-Guané; Gangoiti Muñecas, Patricia; Trueba Conde, Miguel Ángel; Gómez Muñoz, Antonio (American Physiological Society, 2013-06)The bioactive sphingolipid ceramide 1-phosphate (C1P) is implicated in inflammatory responses, and was recently shown to promote cell migration. However, the mechanisms involved in these actions are poorly described. Using ... -
Ceramide and ceramide 1-phosphate in health and disease
Arana Urbieta, Lide; Gangoiti Muñecas, Patricia; Ouro Villasante, Alberto; Trueba Conde, Miguel Ángel; Gómez Muñoz, Antonio (BioMed Central, 2010-02)Sphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the ... -
Generation of Reactive Oxygen Species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate
Arana Urbieta, Lide; Gangoiti Muñecas, Patricia; Ouro Villasante, Alberto; Rivera Líbano, Io Guané; Ordóñez Zaragoza, Marta; Trueba Conde, Miguel Ángel; Lankalapalli, Ravi S.; Bittman, Robert; Gómez Muñoz, Antonio (Elsevier, 2011-12-06)We previously demonstrated that ceramide 1-phosphate (C1P) is mitogenic for fibroblasts and macrophages. However, the mechanisms involved in this action were only partially described. Here, we demonstrate that C1P stimulates ... -
Glycolytic requirements of human cytokine-induced memory-like natural killer cells
Mosteiro Couso, Alba (2020-12-15)[EN] Natural killer (NK) cells are a type of innate lymphoid cells (ILCs) that play a pivotal role fighting against cancer and viral infections. NK cells derive from the CD34+ hematopoietic progenitor cells (HPCs) and ... -
Identificación of ERBB4 and SOX1 role in central nervous system tumors. Implication in medulloblastoma and glioblastoma.
Aldareguía Fernández, Juncal (2020-12-16)Los tumores cerebrales, como el glioblastoma (GBM) en adultos y el meduloblastoma (MB) en niños, representan uno de los retos más importantes de la medicina actual, ya que resisten a las terapias disponibles, recurren y ... -
Identificación of ERBB4 and SOX1 role in central nervous system tumors. Implication in medulloblastoma and glioblastoma.
Aldareguía Fernández, Juncal (2020-12-16)Los tumores cerebrales, como el glioblastoma (GBM) en adultos y el meduloblastoma (MB) en niños, representan uno de los retos más importantes de la medicina actual, ya que resisten a las terapias disponibles, recurren y ... -
Neurotoxicity of the synuclein proteins in cell-based models of Parkinson´s disease
Guerin Darvas, Sofia Marina (2017-01-10)El presente TFG consistió en la mejora de un sistema de expresión de proteínas ("tetOFF protein expression system") para su uso en cultivos neuronales primarios. -
Phosphatidic Acid Stimulates Myoblast Proliferation through Interaction with LPA1 and LPA2 Receptors
Gómez Larrauri, Ana; Gangoiti Muñecas, Patricia; Presa Torre, Natalia; Dominguez Herrera, Asier; Donati, Chiara; Bruni, Paola; Trueba Conde, Miguel Ángel; Gómez Muñoz, Antonio; Ouro Villasante, Alberto (MDPI, 2021-02-01)Phosphatidic acid (PA) is a bioactive phospholipid capable of regulating key biological functions, including neutrophil respiratory burst, chemotaxis, or cell growth and differentiation. However, the mechanisms whereby PA ... -
Proteostasis and Rare Diseases: Congenital Erythropoietic Porphyria and Townes-Brocks Syndrome
Giordano, Immacolata (2020-07-28)El término proteostasis se refiere a todos aquellos procesos biológicos críticos para el buen funcionamiento de la célula. La alteración de las vías reguladoras de la proteostasis puede afectar seriamente la función celular ... -
Regulation of cell growth, survival and migration by ceramide 1-phosphate - implications in lung cancer progression and inflammation
Gómez Larrauri, Ana; Ouro Villasante, Alberto; Trueba Conde, Miguel Ángel; Gómez Muñoz, Antonio (Elsevier, 2021-07)Ceramide 1-phosphate (C1P) is a bioactive sphingolipid that is implicated in the regulation of vital cellular functions and plays key roles in a number of inflammation-associated pathologies. C1P was first described as ... -
Regulation of cell proliferation and migration by phosphatidic acid and ceramide 1-phosphate. Implication in lung cancer and inflammation
Gómez Larrauri, Ana (2023-12-18)According to the World Health Organization (WHO), chronic inflammatory lung diseases, includingasthma, COPD, fibrosis, or lung cancer are among the major causes of death Worldwide. Althoughthese are subjects of intense ... -
Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
Rivera Líbano, Io Guané; Ordóñez Zaragoza, Marta; Presa Torre, Natalia; Gómez Larrauri, Ana; Simón Espinosa, Jorge; Trueba Conde, Miguel Ángel; Gómez Muñoz, Antonio (MDPI, 2015-05)Sphingolipids are major constituents of biological membranes of eukaryotic cells. Many studies have shown that sphingomyelin (SM) is a major phospholipid in cell bilayers and is mainly localized to the plasma membrane of ...