Browsing by Author "Valero Gómez-Lobo, Jorge"
Now showing items 1-7 of 7
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A beta oligomers promote oligodendrocyte differentiation and maturation via integrin beta 1 and Fyn kinase signaling
Quintela López, Tania; Ortiz Sanz, Carolina; Serrano Regal, María Paz; Gaminde Blasco, Adhara Mikaela; Valero Gómez-Lobo, Jorge; Baleriola, Jimena; Sánchez Gómez, María Victoria ; Matute Almau, Carlos José; Alberdi Alfonso, Elena María (Nature Publishing Group, 2019-06-06)Alzheimer's disease (AD) is characterized by a progressive cognitive decline that correlates with the levels of amyloid beta-peptide (A beta) oligomers. Strong evidences connect changes of oligodendrocyte function with the ... -
A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer’s Disease
Luchena Moreno, Celia ; Zuazo Ibarra, Jone; Valero Gómez-Lobo, Jorge; Matute Almau, Carlos José; Alberdi Alfonso, Elena María ; Capetillo González de Zarate, Estíbaliz (Frontiers Media, 2022-04-14)Glial cells are essential to understand Alzheimer's disease (AD) progression, given their role in neuroinflammation and neurodegeneration. There is a need for reliable and easy to manipulate models that allow studying the ... -
Microglia: Development of a human in vitro model, analysis of motility and effects of phagocytosis in the hippocampal neurogenic niche
Paris Guerrero, Ignacio (2022-10-26)This PhD Thesis discusses several topics related to microglia, the resident macrophages of the brain parenchyma. They are derived from yolk sack primitive macrophages that colonize the brain early during embryonic development. ... -
Microglial Phagocytosis Dysfunction in the Dentate Gyrus is Related to Local Neuronal Activity in a Genetic Model of Epilepsy
Sierra Torre, Virginia; Plaza Zabala, Ainhoa ; Bonifazi, Paolo; Abiega Etxabe, Oihane; Díaz Aparicio, Irune; Tegelberg, Saara; Lehesjoki, Anna Elina; Valero Gómez-Lobo, Jorge; Sierra Saavedra, Amanda (Wiley, 2020-11)Objective Microglial phagocytosis of apoptotic cells is an essential component of the brain regenerative response during neurodegeneration. Whereas it is very efficient in physiological conditions, it is impaired in mouse ... -
Microglial phagocytosis of apoptotic cells triggers a neuromodulatory program that supports neurogenesis.
Díaz Aparicio, Irune (2018-07-24)Durante la neurgónesis del hipocampo adulto, la mayoría de las células recién nacidas mueren por apoptosis y son rápidamente eliminadas por la microglía residente del cerebro mediante el proceso denominado fagocitosis. En ... -
Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
Abiega Etxabe, Oihane; Beccari Galeano, Marlene Soledad; Diaz-Aparicio, Irune; Nadjar, Agnes; Layé, Sophie; Leyrolle, Quentin; Gómez-Nicola, Diego; Domercq García, María ; Pérez-Samartín, Alberto; Sánchez-Zafra, Víctor; Paris Guerrero, Ignacio; Valero Gómez-Lobo, Jorge; Savage, Julie C.; Hui, Chin-Wai; Tremblay, Marie-Ève; Deudero, Juan J. P.; Brewster, Amy L.; Anderson, Anne E.; Zaldumbide Dueñas, Laura; Galbarriatu, Lara; Marinas, Ainhoa; Vivanco Ruiz, María del Mar; Matute Almau, Carlos José; Maletic-Savatic, Mirjana; Encinas Pérez, Juan Manuel; Sierra Saavedra, Amanda (2016)Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients ... -
Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus
Martín Suárez, Soraya; Valero Gómez-Lobo, Jorge; Muro García, Teresa; Encinas Pérez, Juan Manuel (Wiley, 2019-08)Adult neurogenesis persists in the hippocampus of most mammal species during postnatal and adult life, including humans, although it declines markedly with age. The mechanisms driving the age-dependent decline of hippocampal ...