Browsing by Author "Valpuesta, José M."
Now showing items 1-3 of 3
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Recognition of Membrane-Bound Fusion-Peptide/MPER Complexes by the HIV-1 Neutralizing 2F5 Antibody : Implications for Anti-2F5 Immunogenicity
Huarte Arrayago, Nerea; Araujo Pasarín, Aitziber; Arranz, Rocio; Lorizate Nogales, Maier; Quendler, Heribert; Kunert, Renate; Valpuesta, José M.; Nieva Escandón, José Luis (Public Library of Science, 2012-12-21)The membrane proximal external region (MPER) of the fusogenic HIV-1 glycoprotein-41 harbors the epitope sequence recognized by 2F5, a broadly neutralizing antibody isolated from an infected individual. Structural mimicry ... -
Structural insights into the ability of nucleoplasmin to assemble and chaperone histone octamers for DNA deposition
Franco Budia, Aitor ; Arranz, Rocio; Fernández Rivero, Noelia; Velázquez Campoy, Adrián; Martín Benito, Jaime; Segura, Joan; Prado Ruiz, Adelina ; Valpuesta, José M.; Muga Villate, Arturo (Nature Publishing Group, 2019-07-01)Nucleoplasmin (NP) is a pentameric histone chaperone that regulates the condensation state of chromatin in different cellular processes. We focus here on the interaction of NP with the histone octamer, showing that NP could ... -
Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-Based Disaggregase
Franco Budia, Aitor ; Cuéllar, Jorge; Fernández Higuero, José Ángel; De la Arada Echevarría, Igor ; Orozco, Natalia; Valpuesta, José M.; Prado Ruiz, Adelina ; Muga Villate, Arturo (MDPI, 2021-11-30)The aggregation of α-synuclein is the hallmark of a collective of neurodegenerative disorders known as synucleinopathies. The tendency to aggregate of this protein, the toxicity of its aggregation intermediates and the ...