Browsing TD-Ciencias de la Vida by Title
Now showing items 750-769 of 848
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Structural studies of the hipersaline adaptation of proteins belonging to halophilic archaea
(2015-10-05)Adaptation of organisms to extreme halophilic environments (> 1 ¿ 2 M) occurs through theaccumulation of large intracellular concentrations of KCl. Their major adaptive feature is theextensive modification of the constituting ... -
Structural study of flavivirus immunomodulator proteins from AEDES AEGYPTI salivary glands.
(2023-02-23)Aedes aegypti bacteria-responsive protein 1 (AgBR1) y neutrophil stimulating factor 1 (NeSt1) son dos proteínas salivales del mosquito Aedes aegypti que actúan como potenciadoras de la infección del virus Zika (ZIKV). En ... -
Structure-function relationships of tumor suppresor ING5
(2017-07-04)La familia ING (INhibitor of Growth) de supresores tumorales está formada por cinco proteínas homólogas que regulan el estado transcripcional de la cromatina por medio del reclutamiento de complejos remodeladores de cromatina ... -
Studies on AUF1-regulated deubiquitinase complexes: USP1/UAF1, USP12/UAF1 and USP46/UAF1
(2017-07-05)Deubiquitinases (DUBs) regulate a wide range of cellular processes and are potential targets for cancer therapy. Our knowledge on the biology of these enzymes is still limited. We focused on three human DUBs (USP1, USP12 ... -
Study of Aspergillus fumigatus pathogenicity and identification of putative virulence genes
(2016-12-02)Aspergillus fumigatus is considered to be the most prevalent airborne pathogenic fungus. lts infection begins with conidial germination in lungs where different types of aspergillosis can be developed. In profoundly ... -
Study of human and mouse dermal fibroblast heterogeneity by single-cell RNA sequencing.
(2023-10-18)The skin is a complex vital organ composed of several layers. The middle layer, the dermis, is mainly composed of fibroblasts that produce the extracellular matrix (ECM) providing structural support. Recent research using ... -
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Study of the Aspergillus fumigatus host-pathogen interaction using transcriptomic techniques and mutant strains generation
(2021-03-26)Aspergillus fumigatus is a filamentous fungus capable to cause a wide range of diseases depending on the immune status of the patient who breath its conidia. The most dangerous disease caused by this fungus is known as ... -
Study of the distribution of nuclear basket-related nucleoporins after histone deacetylase inhibition.
(2021-07-14)El complejo del poro nuclear está constituido por proteínas denominadas nucleoporinas cuya función erasupuestamente restringida al transporte nucleocitoplasmático. Evidencias recientes, sugieren que lasnucleoporinas ... -
Study of the effect of candida albicans recombinant proteins and derived monoclonal antibodies on protumoral processes and as diagnostic and therapeutic tools.
(2018-10-04)Candida albicans is a human commensal yeast that can sometimes cause life-threatening infections, especially in immunocompromised patients. The high mortality rates associated with this fungus make necessary the study of ... -
Study of the epigenetic cellular memory induced by morphine: a next generation sequencing approach
(2019-09-09)Epigenetikak, kanpo faktoreek edo inguruneak norbanakoan izan dezaketen eragina aztertzen du. Azken urteetan, zenbait ikerketek erakutsi dutenez, inguruneak eragin zuzena izan dezake norbanako helduaren ezaugarri ... -
Study of the impact of hepatocytes-secreted extracellular vesicles in liver diseases
(2023-10-20)Las vesículas extracelulares (EVs) son pequeñas partículas delimitadas por membranas lipídicas que las células generan y secretan al espacio extracelular. Su función principal es facilitar la comunicación intracelular, y ... -
Study of the long-lasting effects of ethanol consumption during adolescence on cannabinoid type 1 receptor-dependent synaptic transmission and plasticity in dentate gyrus synapses.
(2018-10-17)El consumo excesivo de alcohol, especialmente durante la adolescencia, es una preocupación generalizada de salud pública. Investigaciones en la última década han puesto de manifiesto que el consumo de etanol (EtOH) y el ... -
Studying the role of E2F1 and E2F2 in the metabolism of nucleotides: therapeutic implications for the treatment of prostate cancer.
(2022-05-27)E2F-dependent transcriptional network ensures the timely entry of cells into S-phase through the regulation of a vast array of genes involved in DNA replication and cell cycle progression. In this Thesis, we aimed to ... -
SU-8 microprobes for biomedical applications
(2014-01-30)[ES]La presente tesis doctoral aborda el diseño, fabricación, encapsulado, y caracterización de microagujas de SU-8 para aplicaciones médicas. En la actualidad existe una amplia variedad de agujas para el registro, ... -
Suicidio y desempleo: Barakaldo 2003-2014
(2016-03-18)La OMS y otras influyentes fuentes de divulgación del conocimiento científico han alertado de los potenciales efectos que las eventuales crisis económicas pueden tener sobre la salud de los habitantes. La presente Tesis ... -
Suitability of magnetotactic bacteria as biomedical agents
(2022-07-20)Las bacterias magnetotácticas son microorganismos acuáticos capaces de sintetizar una o varias cadenas de orgánulos magnéticos intracelulares denominados magnetosomas. Los magnetosomas están compuestos por un núcleo mineral ... -
Synaptic alterations in the hippocampus of an animal model of progressive parkinsonism and the effect of dopaminergic treatments
(2022-03-04)This Ph.D. project is focused on the characterization of pathological events in the hippocampus, which could be related to non-motor manifestation in Parkinson's disease such as behavioral and memory impairments. For that ... -
Synaptic dysfunction in Parkinson's Disease: functional and ultrastructural study of the striatal synapses in an animal model of progressive parkinsonism
(2021-02-26)This Ph.D. project involves the temporal sequence of the earliest functional and structural events in the striatal synapses in a rat model of progressive parkinsonism induced by overexpression of human ¿-synuclein (h¿-syn) ... -
Synthesis and evaluation of polymer-based nanocarriers for siRNA delivery
(2023-11-30)El Siglo XX se han logrado importantes avances en la investigación de esta novedosa área, con el objetivo de trasladar a la clínica nuevas terapias basadas en RNAi. El ARN pequeño de interferencia (siRNA, por sus siglas ...