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Sphingosine 1-phosphate (S1P) system in healthy brain and alzheimer's disease
(2021-01-27)
The physiological consequences of the super-specialization of the lipids in the different regions and cellular types of the central nervous system (CNS), remain largely being a mystery. In fact, the so-called neurolipids, ...
Pharmacometric analysis of the in vitro activity of echinocandins, amphotericin B and isavuconazole against Candida Auris
(2021-07-19)
C. auris is a multidrug-resistant fungal pathogen that has recently emerged globally as a cause of life-threatening invasive infections. Despite the increasing concern on the reduced treatment options of C. auris infections, ...
Optimizing pharmacotherapy in the elderly using modelling and simulation methods. Application to Bilastine
(2021-11-29)
This research project was designed to acquire a deeper knowledge on how physiological changes during aging mayaffect the pharmacokinetics (PK) and pharmacodynamics (PD). Elderly adults are a vulnerable population due to ...