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Investigating the role of HIF2a and the type I interferon signalling in cancer hypoxia
(2020-03-27)
La hipoxia es una de las principales características de los tumores sólidos. A medida que el tumor crece, se generan regiones a las que no llega el suministro de oxígeno y nutrientes debido a la distancia que se encuentran ...
Investigating the role of miRNA binding in B-cell lymphoma
(2018-12-20)
En el presente trabajo se ha estudiado la función de los microRNAs en linfoma de célula B. Por un lado se analizó la presencia de mutaciones en sitios de unión de microRNAs que habían sido identificadas en pacientes con ...
Osasun sistemak immigranteen osasun eskubidea errespetatzen du? Emakume immigranteen Euskadiko osasun zerbitzuetarako sarbidearen azterketa
(2019-04-15)
Tesi honek emakume inmigranteen Euskadiko osasun zerbitzuetarako sarbidea aztertzeko helburua dauka. Ikerketa kuantitatibo batean eta bi ikerketa kualitatibotan oinarritzen da. Lehenengo ikerketarako datu bilketa, kontsulta ...
Azole resistance mechanisms in Candida albicans. Exposure to fluconazole and the role of the Erg11 Y477C, Tac1 S758F and Mrr2 A311V new mutations by CRISPR-Cas9 gene editing.
(2022-12-02)
Invasive fungal infections caused by Candida species, among which Candida albicans is the predominant one, are the fourth cause of nosocomial infections. Most Candida infections are treated with azoles, thus, acquisition ...
Role of Oncostatin M signalling axis in breast cancer progression: Implications in the tumour microenvironment
(2021-03-12)
El microambiente tumoral (TME) está compuesto por diferentes tipos celulares, entre los que se incluyen los fibroblastos, adipocitos, células endoteliales e inmunes, que interaccionan entre ellas de forma compleja y que, ...
Characterization and evaluation of the antifungal activity of antibodies raised against Candida Albicans germ tube in a rabbit model of infection and patients with invasive Candidiasis.
(2018-07-12)
In the last decades, the incidence of Invasive Candidiasis has dramatically increased. Since Candida is a common component of human microbiota, the distinction between invasion and colonization is complicated. Our group ...
Novel biomarkers for invasive candidiasis. Selection, characterization and evaluation of Hyr1, a Candida albicans hyphally regulated cell wall protein
(2024-02-23)
Invasive candidiasis is a life-threatening disease caused by Candida species. The prognosis of this disease is closely related to early diagnosis; however, blood culture, the current gold standard for the diagnosis of ...