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The endocannabinoid system in experimental models of Alzheimer's disease
(2017-06-29)
Durante la progresión de la enfermedad de Alzheimer (EA) se produce una degeneración del sistema de neurotransmisión colinérgico del prosencéfalo basal, que conduce a una pérdida progresiva e irreversible de funciones ...
Learning and memory improvement mediated by CB1 cannabinoid receptors in animal models of cholinergic dysfunction
(2018-10-26)
The selective vulnerability of the basal forebrain cholinergic system (BFCS) is responsible for most of the clinical alterations in learning and memory processes that are characteristic of the Alzheimer¿s disease (AD). The ...
Role of G protein coupled inwardly rectifier K+ channels (GIRK) on the neurobiology depression
(2014-02-11)
[EN] Major depression is a recurrent or chronic mood disorder with impaired psychosocial function, and an increased tendency of relapse for patients who fail to reach remission. In industrialized societies, it affects 15% ...
Molecular mechanisms underlying cannabis abuse and schizophrenia: Focus on 5-HT2A receptors and Akt/mTOR signaling pathway
(2020-07-09)
Schizophrenia is a chronic and disabling mental illness that affects around 20 million people worldwide. The etiology of the disorder is multifactorial, and different genetic and environmental factors take part in its onset ...
Effect of novel ryanodine receptor modulators in mouse and human models of Duchenne muscular dystrophy
(2017-05-31)
La distrofia muscular de Duchenne (DMD) es una enfermedad hereditaria ligada al cromosoma X queafecta a uno de cada 3500 varones. Esta enfermedad se caracteriza por la degeneración progresiva de lasfibras musculares que ...
Network dynamic of Basal Ganglia circuits in normal and parkinsonian conditions
(2022-12-16)
Basal ganglia (BG) circuits are involved in different functions from movement control to cognitive/motivational processes. The loss of dopamine (DA) in these circuits triggers Parkinson's disease (PD). In addition to DA ...
Sphingosine 1-phosphate (S1P) system in healthy brain and alzheimer's disease
(2021-01-27)
The physiological consequences of the super-specialization of the lipids in the different regions and cellular types of the central nervous system (CNS), remain largely being a mystery. In fact, the so-called neurolipids, ...
Pharmacometric analysis of the in vitro activity of echinocandins, amphotericin B and isavuconazole against Candida Auris
(2021-07-19)
C. auris is a multidrug-resistant fungal pathogen that has recently emerged globally as a cause of life-threatening invasive infections. Despite the increasing concern on the reduced treatment options of C. auris infections, ...
Characterization of buspirone effect on output basal ganglia nuclei in 6-hydroxydopamine lesioned rats with and without long-term levodopa treatment.
(2020-05-22)
La enfermad de Párkinson es un trastorno neurodegenerativo en el que varios sistemas de neurotransmisión se ven afectados. En los últimos años, numerosas evidencias clínicas y experimentales han demostrado el papel del ...