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Biofunctional iron oxide nanoparticles as vaccine adjuvants for enhanced anti-cancer immunotherapy
(2017-12-15)
En esta tesis se aborda el diseño y caracterización de una vacuna basada en nanoparticulas de óxido de hierro para su aplicación en inmunoterapia del cáncer. Concretamente, las nanoparticulas están biofuncionalizadas con ...
New neuroimaging methods for clinical neuroscience and neurological disorders
(2015-10-27)
Clinical neuroscience today makes use of state-of-the-art neuroimaging to study structural and functional brain data to improve diagnosis and prognosis in different neurological disorders.In this thesis dissertation, I ...
DLK1 and DLK2 characterization in mouse salivary gland development
(2015-12-11)
Organogenesia seinalizazio bide ezberdinez gidatutako prozesu konplexua da. Askotan organu ezberdinen garapena seinalizazio faktore berdinez dago erregulatuta. Gainera, seinalizazio bideen ikerketa garapena ezagutarazteko ...
Neuroprotective effects of resveratrol and docosahexaenoic acid antioxidants in perinatal hypoxic-ischemic brain injury in rats
(2015-12-11)
Umeen erikortasun eta hilkortasunaren kausa nagusienetariko bat hipoxia-iskemia perinatala da, hortazbere aurkako estrategia neurobabesle berri eta eraginkorragoak aurkitzearen premia. Zentzu honetanerresberatrola eta azido ...
Computational predictive modeling of integrated cerebral metabolism, electrophysiology and hemodynamics.
(2019-02-12)
Understanding the energetic requirement of brain cells during resting state and during high neural activity is a very active research area where mathematical models have contributed significantly by providing a context for ...
Birsortze neuralean erabiltzeko hortz muineko ama zelulen gaitasun funtzionalaren azterketa
(2018-12-19)
Ezaguna da hortz muin helduak zelula ama populazio garrantzitsu bat duela barnean, hauei, hortz muineko zelula amak deritze (ingelesez, dental pulp stem cells, DPSCs). Oinarrizko egoeran aurkezten dituzten zelula neuralen ...
Role of notch and wnt signaling in metabolic and epigenetic reprogramming of human dental pulp stem cells (DPSCs)
(2019-03-01)
Las Células Stem de Pulpa Dental (DPSCs; en inglés) son células madre extraídas de la pulpa dental de terceros molares de pacientes. Presentan unas propiedades que las convierte en un recurso especialmente interesante para ...
Development of a cartilage tissue engineering construct based on hASCs spheroids differentiated under hypoxia in a chitosan/chitin nanocrystals 3D scaffold.
(2019-01-14)
The generation of a cartilage tissue engineering (TE) construct is currently a viable strategy for the treatment of osteoarthritis. Such construct requires a biomaterial with optimal properties, including biocompatibility, ...
Neuroprotection of retinal ganglion cells by Müller Glia in vitro in health and disease
(2019-10-07)
Las células ganglionares de la retina (RGCs) son las únicas neuronas aferentes de la retina y transmiten la información visual al cerebro a través de sus axones, que forman el nervio óptico y su muerte causa una ceguera ...
Development of new methods in biomedical engineering for brain connectivity biomarkers in epilepsy and other pathological conditions
(2018-05-07)
The aim of this thesis is to humbly explore the application of diverse methodologies and theories comingfrom Computer Sciences, Mathematics and Physics in the field of neurosciences, with an special focus onneurodegenerative ...