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Metabolic alterations in prostate cancer pathogenesis
(2016-09-16)
Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs thatsustain cell growth, proliferation and promote cancer initiation and progression. In this thesis workwe describe a novel molecular mechanism ...
Physical principles underlying structure, mechanics and dynamic re-organization of hyaluronan-rich matrices - from tissues to supramolecular models in experiment and theory
(2016-07-29)
The goal of this research project is to understand the physical principles that underlie the structure, mechanics and dynamic reorganization of hyaluronan-rich pericellular and extracellular matrices. Many cells produce a ...
Soils under long-term aided phytostabilization are a reservoir for transmissible antibiotic resistance plasmids.
(2016-06-28)
En la actualidad, cada vez son más habituales los brotes infecciosos donde la mayoría de los antibióticos se muestran ineficaces debido a un creciente número de patógenos resistentes a los mismos. Incluso algunos de los ...
Mechanisms of MPER helix binding at membrane interfaces and implications for the broad neutralization of HIV by antibodies
(2016-12-16)
En esta tesis se lleva a cabo un estudio detallado de la función que desempeña el lazo CDR-H3 de losanticuerpos anti MPER 4E10 y 10E8 en al unión y neutralización del VIH así como la contribución de launión directa a lípidos ...