Browsing ACHUCARRO-Publications by Author "Matute, Carlos"
Now showing items 1-20 of 21
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1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death
Manterola, L.; Hernando Rodríguez, M.; Ruiz Núñez, Asier; Apraiz, A.; Arrizabalaga Uriarte, Oskar
; Vellon, L.; Alberdi Alfonso, Elena María
; Cavaliere, Fabio; Lacerda, Hadriano M.; Jimenez, S.; Parada, L. A.; Matute Almau, Carlos José; Zugaza Gurruchaga, José Luis
(Nature Publishing Group, 2013-01)
1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ... -
A beta oligomers promote oligodendrocyte differentiation and maturation via integrin beta 1 and Fyn kinase signaling
Quintela López, Tania; Ortiz Sanz, Carolina; Serrano Regal, María Paz; Gaminde Blasco, Adhara Mikaela; Valero Gómez-Lobo, Jorge; Baleriola, Jimena; Sánchez Gómez, María Victoria; Matute Almau, Carlos José; Alberdi Alfonso, Elena María
(Nature Publishing Group, 2019-06-06)
Alzheimer's disease (AD) is characterized by a progressive cognitive decline that correlates with the levels of amyloid beta-peptide (A beta) oligomers. Strong evidences connect changes of oligodendrocyte function with the ... -
Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease
Alberdi Alfonso, Elena María; Wyssenbach Ibarra, Ane; Alberdi, María; Sánchez Gómez, María Victoria
; Cavaliere, Fabio; Rodríguez, José J.; Verkhratsky, Alexei; Matute Almau, Carlos José (2013)
Neurotoxic effects of amyloid β peptides are mediated through deregulation of intracellular Ca2+ homeostasis and signaling, but relatively little is known about amyloid β modulation of Ca2+ homeostasis and its pathological ... -
CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels
Ruiz Núñez, Asier; Alberdi Alfonso, Elena María
; Matute Almau, Carlos José (Nature Publishing Group, 2014-04)
Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ... -
Contribution of Pannexin1 to Experimental Autoimmune Encephalomyelitis
Lutz, Sarah E.; González Fernández, Estibaliz; Chara Ventura, Juan Carlos; Pérez Samartín, Alberto Luis; Tarassishin, Leonid; Negoro, Hiromitsu; Patel, Naman K.; Suadicani, Sylvia O.; Lee, Sunhee C.; Matute Almau, Carlos José; Scemes, Eliana (Public Library of Science, 2013-06)
Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. ... -
Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine
Moreno, Beatriz; Lopez, Iciar; Fernández-Díez, Begoña; Gottlieb, Miroslav; Matute Almau, Carlos José; Sánchez Gómez, María Victoria; Domercq García, María
; Giralt, Albert; Alberch, Jordi; Collon, Kevin W.; Zhang, Helen; Parent, Jack M.; Teixido, Meritxell; Giralt, Ernest; Ceña, Valentín; Posadas, Inmaculada; Martínez-Pinilla, Eva; Villoslada, Pablo; Franco, Rafael (Public Library Science, 2014-03-05)
Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ... -
Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
Cipriani, Raffaela; Chara Ventura, Juan Carlos; Rodríguez-Antigüedad Zarranz, Alfredo; Matute Almau, Carlos José (Biomed Central, 2017-07-24)
Background: FTY720 (fingolimod, Gilenya (TM)) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts ... -
FTY720 attenuates excitotoxicity and neuroinflammation
Cipriani, Raffaela; Chara Ventura, Juan Carlos; Rodríguez-Antigüedad Zarranz, Alfredo; Matute Almau, Carlos José (BioMed Central, 2015-05-08)
Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ... -
Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling
The inflammatory response is a major factor in stroke pathophysiology and contributes to secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent work in experimental cerebral ischemia has ... -
Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
Abiega Etxabe, Oihane; Beccari Galeano, Marlene Soledad; Diaz-Aparicio, Irune; Nadjar, Agnes; Layé, Sophie; Leyrolle, Quentin; Gómez-Nicola, Diego; Domercq García, María; Pérez-Samartín, Alberto; Sánchez-Zafra, Víctor; Paris Guerrero, Ignacio; Valero Gómez-Lobo, Jorge; Savage, Julie C.; Hui, Chin-Wai; Tremblay, Marie-Ève; Deudero, Juan J. P.; Brewster, Amy L.; Anderson, Anne E.; Zaldumbide Dueñas, Laura; Galbarriatu, Lara; Marinas, Ainhoa; Vivanco Ruiz, María del Mar; Matute Almau, Carlos José; Maletic-Savatic, Mirjana; Encinas Pérez, Juan Manuel; Sierra Saavedra, Amanda (2016)
Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients ... -
Neurotransmitter signaling in the pathophysiology of microglia
Domercq García, María; Vázquez Villoldo, Nuria; Matute Almau, Carlos José (Frontiers Research Foundation, 2013)
Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ... -
NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation
Cavaliere, Fabio; Benito Muñoz, Mónica; Panicker, Mitradas; Matute Almau, Carlos José (Frontiers Research Foundation, 2013-12-18)Multipotent cells from the juvenile subventricular zone (SVZ) possess the ability to differentiate into new neural cells. Depending on local signals, SVZ can generate new neurons, astrocytes, or oligodendrocytes. We ... -
Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate
Cavaliere, Fabio; Urra, O.; Alberdi Alfonso, Elena María; Matute Almau, Carlos José (Nature Publishing Group, 2012-02)
We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation. Glutamate stimulated oligodendrocyte differentiation from SVZ-derived ... -
Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders
Cavaliere, Fabio; Benito Muñoz, Mónica; Matute Almau, Carlos José (Hindawi, 2016)Neural regeneration resides in certain specific regions of adult CNS. Adult neurogenesis occurs throughout life, especially from the subgranular zone of hippocampus and the subventricular zone, and can be modulated in ... -
Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders
Cavaliere, Fabio; Benito-Muñoz, Monica; Matute Almau, Carlos José (null, 2016)Neural regeneration resides in certain specific regions of adult CNS. Adult neurogenesis occurs throughout life, especially from the subgranular zone of hippocampus and the subventricular zone, and can be modulated in ... -
PET Imaging with [18F]FSPG Evidences the Role of System xc- on Brain Inflammation Following Cerebral Ischemia in Rats
Domercq García, María; Szczupak, Boguslaw; Gejo, Jon; Gómez-Vallejo, Vanessa; Padró, Daniel; Gona, Kiran Babu; Dollé, Frédéric; Higuchi, Makoto; Matute Almau, Carlos José; Llop Roig, Jordi
; Martín Muñoz, Abraham (2016)
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Pio del Rio Hortega and the discovery of the oligodendrocytes
Pérez Cerdá, Fernando; Sánchez Gómez, María Victoria
; Matute Almau, Carlos José (Frontiers Research Foundation, 2015-07-07)
Rio del Rio Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramon y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolas ... -
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis
Ruiz de Azúa García, Sonia; Matute Almau, Carlos José; Stertz, Laura; Mosquera, Fernando; Palomino Fernández de Larrea, Aitor; De la Rosa, Iris; Barbeito, Sara; Vega, Patricia; Kapczinski, Flavío; González Pinto Arrillaga, Ana María
(BioMed Central, 2013)
Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether Brain ... -
Subclinical Depressive Symptoms and Continued Cannabis Use: Predictors of Negative Outcomes in First Episode Psychosis
González Ortega, Itxaso; Alberich, Susana; Echeburúa Odriozola, Enrique
; Aizpuru Barandiaran, Felipe
; Millán, Eduardo; Vieta, Eduard; Matute Almau, Carlos José; González Pinto Arrillaga, Ana María
(Public Library Science, 2015-04-15)
Background Although depressive symptoms in first episode psychosis have been associated with cannabis abuse, their influence on the long-term functional course of FEP patients who abuse cannabis is unknown. The aims of ... -
Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome
Borralleras, Cristina; Mato Santos, Susana; Amédée, Thierry; Matute Almau, Carlos José; Mulle, Christophe; Pérez-Jurado, Luis A.; Campuzano, Victoria (null, 2016)
Mice heterozygous for a complete deletion (CD) equivalent to the most common deletion found in individuals with Williams-Beuren syndrome (WBS) recapitulate relevant features of the neurocognitive phenotype, such as ...