Browsing ACHUCARRO-Publications by Author "Alberdi, Elena"
Now showing items 1-5 of 5
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1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death
Manterola, L.; Hernando Rodríguez, M.; Ruiz Núñez, Asier ; Apraiz, A.; Arrizabalaga Uriarte, Oskar ; Vellon, L.; Alberdi Alfonso, Elena María ; Cavaliere, Fabio; Lacerda, Hadriano M.; Jimenez, S.; Parada, L. A.; Matute Almau, Carlos José; Zugaza Gurruchaga, José Luis (Nature Publishing Group, 2013-01)1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ... -
A beta oligomers promote oligodendrocyte differentiation and maturation via integrin beta 1 and Fyn kinase signaling
Quintela López, Tania; Ortiz Sanz, Carolina; Serrano Regal, María Paz; Gaminde Blasco, Adhara Mikaela; Valero Gómez-Lobo, Jorge; Baleriola, Jimena; Sánchez Gómez, María Victoria ; Matute Almau, Carlos José; Alberdi Alfonso, Elena María (Nature Publishing Group, 2019-06-06)Alzheimer's disease (AD) is characterized by a progressive cognitive decline that correlates with the levels of amyloid beta-peptide (A beta) oligomers. Strong evidences connect changes of oligodendrocyte function with the ... -
Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease
Alberdi Alfonso, Elena María ; Wyssenbach Ibarra, Ane; Alberdi, María; Sánchez Gómez, María Victoria ; Cavaliere, Fabio; Rodríguez, José J.; Verkhratsky, Alexei; Matute Almau, Carlos José (2013)Neurotoxic effects of amyloid β peptides are mediated through deregulation of intracellular Ca2+ homeostasis and signaling, but relatively little is known about amyloid β modulation of Ca2+ homeostasis and its pathological ... -
CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels
Ruiz Núñez, Asier ; Alberdi Alfonso, Elena María ; Matute Almau, Carlos José (Nature Publishing Group, 2014-04)Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ... -
Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate
Cavaliere, Fabio; Urra, O.; Alberdi Alfonso, Elena María ; Matute Almau, Carlos José (Nature Publishing Group, 2012-02)We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation. Glutamate stimulated oligodendrocyte differentiation from SVZ-derived ...