Now showing items 1-12 of 12

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      1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death 

      Manterola, L.; Hernando Rodríguez, M.; Ruiz Núñez, Asier; Apraiz, A.; Arrizabalaga, O.; Vellon, L.; Alberdi Alfonso, Elena María; Cavaliere, Fabio; Lacerda, H. M.; Jimenez, S.; Parada, L. A.; Matute Almau, Carlos José; Zugaza Gurruchaga, José Luis (Nature Publishing Group, 2013-01)
      1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ...
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      CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels 

      Ruiz Núñez, Asier; Alberdi Alfonso, Elena María; Matute Almau, Carlos José (Nature Publishing Group, 2014-04)
      Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores ...
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      From the Cajal alumni Achucarro and Rio-Hortega to the rediscovery of never-resting microglia 

      Tremblay, Marie-Ève; Lecours, Cynthia; Samson, Louis; Sánchez Zafra, Víctor; Sierra Saavedra, Amanda (Frontiers Research Foundation, 2015-04-14)
      Under the guidance of Ramon y Cajal, a plethora of students flourished and began to apply his silver impregnation methods to study brain cells other than neurons: the neuroglia. In the first decades of the twentieth century, ...
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      FTY720 attenuates excitotoxicity and neuroinflammation 

      Cipriani, Raffaela; Chara Ventura, Juan Carlos; Rodríguez Antigüedad, Alfredo; Matute Almau, Carlos José (BioMed Central, 2015-05-08)
      Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy ...
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      Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis 

      Sierra Saavedra, Amanda; Abiega Etxabe, Oihane; Shahraz, Anahita; Neumann, Harald (Frontiers Research Foundation, 2013-01)
      Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections and disease. In addition, microglia has a more benign, less explored ...
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      Neurotransmitter signaling in the pathophysiology of microglia 

      Domercq García, María; Vázquez Villoldo, Nuria; Matute Almau, Carlos José (Frontiers Research Foundation, 2013)
      Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ...
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      Never-resting microglia: physiological roles in the healthy brain and pathological implications 

      Sierra Saavedra, Amanda; Tremblay, Marie Eve; Wake, Hiroaki (Frontiers Research Foundation, 2014-08-15)
      Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a ...
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      NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation 

      Cavaliere, Fabio; Benito Muñoz, Mónica; Panicker, Mitradas; Matute Almau, Carlos José (Frontiers Research Foundation, 2013-12-18)
      Multipotent cells from the juvenile subventricular zone (SVZ) possess the ability to differentiate into new neural cells. Depending on local signals, SVZ can generate new neurons, astrocytes, or oligodendrocytes. We ...
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      Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate 

      Cavaliere, Fabio; Urra, O.; Alberdi Alfonso, Elena María; Matute Almau, Carlos José (Nature Publishing Group, 2012-02)
      We used multipotent stem cells (MSCs) derived from the young rat subventricular zone (SVZ) to study the effects of glutamate in oligodendrocyte maturation. Glutamate stimulated oligodendrocyte differentiation from SVZ-derived ...
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      Pio del Rio Hortega and the discovery of the oligodendrocytes 

      Pérez Cerdá, Fernando; Sánchez Gómez, María Victoria; Matute Almau, Carlos José (Frontiers Research Foundation, 2015-07-07)
      Rio del Rio Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramon y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolas ...
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      Purinergic signaling: a common pathway for neural and mesenchymal stem cell maintenance and differentiation 

      Cavaliere, Fabio; Donno, Claudia; D’Ambrosi, Nadia (null, 2015)
      Extracellular ATP, related nucleotides and adenosine are among the earliest signaling molecules, operating in virtually all tissues and cells. Through their specific receptors, namely purinergic P1 for nucleosides and P2 ...
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      Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome 

      Borralleras, Cristina; Mato, Susana; Amédée, Thierry; Matute Almau, Carlos José; Mulle, Christophe; Pérez-Jurado, Luis A.; Campuzano, Victoria (null, 2016)
      Mice heterozygous for a complete deletion (CD) equivalent to the most common deletion found in individuals with Williams-Beuren syndrome (WBS) recapitulate relevant features of the neurocognitive phenotype, such as ...