Search

Now showing items 1-4 of 4

Subclinical Depressive Symptoms and Continued Cannabis Use: Predictors of Negative Outcomes in First Episode Psychosis

González Ortega, Itxaso; Alberich, Susana; Echeburúa Odriozola, Enrique; Aizpuru Barandiaran, Felipe; Millán, Eduardo; Vieta, Eduard; Matute Almau, Carlos José; González Pinto Arrillaga, Ana María (Public Library Science, 2015-04-15)

Background Although depressive symptoms in first episode psychosis have been associated with cannabis abuse, their influence on the long-term functional course of FEP patients who abuse cannabis is unknown. The aims of ...

Contribution of Pannexin1 to Experimental Autoimmune Encephalomyelitis

Lutz, Sarah E.; González Fernández, Estibaliz; Chara Ventura, Juan Carlos; Pérez Samartín, Alberto Luis; Tarassishin, Leonid; Negoro, Hiromitsu; Patel, Naman K.; Suadicani, Sylvia O.; Lee, Sunhee C.; Matute Almau, Carlos José; Scemes, Eliana (Public Library of Science, 2013-06)

Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. ...

Differential Neuroprotective Effects of 5 '-Deoxy-5 '-Methylthioadenosine

Moreno, Beatriz; Lopez, Iciar; Fernández-Díez, Begoña; Gottlieb, Miroslav; Matute Almau, Carlos José; Sánchez Gómez, María Victoria; Domercq García, María; Giralt, Albert; Alberch, Jordi; Collon, Kevin W.; Zhang, Helen; Parent, Jack M.; Teixido, Meritxell; Giralt, Ernest; Ceña, Valentín; Posadas, Inmaculada; Martínez-Pinilla, Eva; Villoslada, Pablo; Franco, Rafael (Public Library Science, 2014-03-05)

Background: 5'-deoxy-5'-methylthioadenosine (MTA) is an endogenous compound produced through the metabolism of polyamines. The therapeutic potential of MTA has been assayed mainly in liver diseases and, more recently, in ...

Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

Abiega, Oihane; Beccari, Sol; Diaz-Aparicio, Irune; Nadjar, Agnes; Layé, Sophie; Leyrolle, Quentin; Gómez-Nicola, Diego; Domercq García, María; Pérez-Samartín, Alberto; Sánchez-Zafra, Víctor; Paris, Iñaki; Valero, Jorge; Savage, Julie C.; Hui, Chin-Wai; Tremblay, Marie-Ève; Deudero, Juan J. P.; Brewster, Amy L.; Anderson, Anne E.; Zaldumbide Dueñas, Laura; Galbarriatu, Lara; Marinas, Ainhoa; Vivanco, Maria dM; Matute Almau, Carlos José; Maletic-Savatic, Mirjana; Encinas Pérez, Juan Manuel; Sierra Saavedra, Amanda (2016)

Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients ...