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The role of osteopontin in liver fibrosis

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Tesis Doctoral (3.214Mb)
Date
2017-09-19
Author
Syn, Wing-Kin
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URI
http://hdl.handle.net/10810/24048
Abstract
Osteopontin (OPN) is a cytokine and matrix molecule that is upregulated in human and mouse models of chronic liver injury and directly promotes liver fibrogenesis by activating hepatic stellate cells (HSC) and liver progenitors (LPC). OPN is secreted by multiple cell types including HSC, LPC, as well as recruited immune cells such as natural killer T (NKT) cells, which amplify the fibrogenic response. In vivo, OPN neutralization abrogates the LPC response, inhibits HSC activation, and reduces liver fibrosis, thus demonstrating that targeting OPN is a potentially attractive anti-fibrotic strategy.
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DSpace software copyright © 2002-2016  DuraSpace
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EHU Bilbioteka