Michael initiated organocatalytic cascade reactions

Abstract

The methodologies based on Michael initiated cascade reactions represent avery useful synthetic strategy for the formation of complex compounds, startingfrom simple substrates and using straightforward procedures. In this dissertation,the organocatalysis has been used as the main tool to promote the reactions and toachieve an efficient enantiocontrol, employing chiral amines as stereoinductorselements, under iminium ion activation, towards the synthesis of enantioenrichedchiral proline derivatives, bicyclic and tricyclic compounds in good yields.Moreover, as part of a short stay in the Prof. Christmann group at Free Universityof Berlin, the total synthesis of the natural product (+)-Greek tobacco lactone hasbeen completed.